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Glenister R, McDaniel K, Francis H, et al. Therapeutic actions of melatonin on gastrointestinal cancer development and progression. Transl Gastrointest Cancer. 2013;2(1)doi: 10.3978/j.issn.2224-4778.2012.08.03.
Glenister, R., McDaniel, K., Francis, H., Venter, J., Jensen, K., Dusio, G., Gaudio, E., Glaser, S., Meng, F., & Alpini, G. (2013). Therapeutic actions of melatonin on gastrointestinal cancer development and progression. Translational gastrointestinal cancer, 2(1), . https://doi.org/10.3978/j.issn.2224-4778.2012.08.03
Glenister, Rachael, et al. "Therapeutic actions of melatonin on gastrointestinal cancer development and progression." Translational gastrointestinal cancer vol. 2,1 (2013). doi: https://doi.org/10.3978/j.issn.2224-4778.2012.08.03
Glenister R, McDaniel K, Francis H, Venter J, Jensen K, Dusio G, Gaudio E, Glaser S, Meng F, Alpini G. Therapeutic actions of melatonin on gastrointestinal cancer development and progression. Transl Gastrointest Cancer. 2013 Jan 01;2(1). doi: 10.3978/j.issn.2224-4778.2012.08.03. PMID: 24312749; PMCID: PMC3848957.
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Transl Gastrointest Cancer. 2013 Jan 01;2(1). doi: 10.3978/j.issn.2224-4778.2012.08.03.

Therapeutic actions of melatonin on gastrointestinal cancer development and progression.

Translational gastrointestinal cancer

Rachael Glenister, Kelly McDaniel, Heather Francis, Julie Venter, Kendal Jensen, Giuseppina Dusio, Eugenio Gaudio, Shannon Glaser, Fanyin Meng, Gianfranco Alpini

PMID: 24312749 PMCID: PMC3848957 DOI: 10.3978/j.issn.2224-4778.2012.08.03

Abstract

Melatonin exerts a multitude of physiological functions including the regulation of the sleep cycle and circadian rhythm. Although the synthesis of melatonin in the pineal gland is regulated by changes in the light/dark cycle, the release of melatonin in the gastrointestinal tract is related to food consumption. Melatonin regulates antioxidative processes and it improves T-helper cell response by stimulating the production of specific cytokines. Melatonin is directly involved in preventing tumor initiation, promotion, and progression in a variety of cancers of the gastrointestinal tract including colorectal cancer, cholangiocarcinoma, hepatocarcinoma, and pancreatic carcinoma. This paper is a review of the literature regarding melatonin in the gastrointestinal tract and as a potential therapy for gastrointestinal cancers.

Keywords: Gastrointestinal cancer; T-helper cell; cholangiocarcinoma; colorectal cancer; hepatocarcinoma; melatonin; pancreatic cancer

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