Adv Pharm Bull. 2013;3(1):227-30. doi: 10.5681/apb.2013.037. Epub 2013 Feb 07.

Synthesis and antimicrobial evaluation of certain novel thiazoles.

Advanced pharmaceutical bulletin

Meesaraganda Sreedevi, Aluru Raghavendra Guru Prasad, Yadati Narasimha Spoorthy, Lakshmana Rao Krishna Rao Ravindranath

PMID: 24312840 PMCID: PMC3846066 DOI: 10.5681/apb.2013.037

Abstract

PURPOSE: This article makes an attempt to synthesize certain compounds containing thiazole and imidazole moieties and screen for the antimicrobial properties.

METHODS: The novel compounds synthesized were characterized by elemental analysis, IR and (1)HNMR spectral data. The antimicrobial activity of novel compounds was evaluated by cup plate method.

RESULTS: The compound p-t showed more antibacterial activity than that of the standard. p-hp and p-as showed considerable antibacterial activity. p-t demonstrated higher antifungal activity than that of the standard while p-hp and p-as showed considerable antifungal activity.

CONCLUSION: The antimicrobial activity studies were conducted on certain selected bacteria and fungi. In each case antimicrobial activity of the compounds was compared with that of standards. p-t, p-hp, p-np, p-cp, p-ts and p-as showed considerable antimicrobial activity.

Keywords: Antimicrobial activity; Characterization; Imidazole moiety; Synthesis; Thiazole moiety

References

1. Eur J Med Chem. 2010 Feb;45(2):651-60 - PubMed
2. Eur J Med Chem. 2010 Jan;45(1):387-92 - PubMed
3. J Med Chem. 2010 Mar 25;53(6):2409-17 - PubMed
4. Eur J Med Chem. 2009 Dec;44(12):4944-53 - PubMed
5. Acta Pharm. 2011 Jun;61(2):187-201 - PubMed
6. Bioorg Med Chem. 2007 Feb 15;15(4):1725-31 - PubMed
7. Adv Pharm Bull. 2013;3(1):153-9 - PubMed
8. Eur J Med Chem. 2009 Jun;44(6):2347-53 - PubMed

Publication Types

• Journal Article