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Ma D, Wolf P, Clough AV, et al. The performance of MLEM for dynamic imaging from simulated few-view, multi-pinhole SPECT. IEEE Trans Nucl Sci. 2013;60(1)doi: 10.1109/TNS.2012.2214235.
Ma, D., Wolf, P., Clough, A. V., & Schmidt, T. G. (2013). The performance of MLEM for dynamic imaging from simulated few-view, multi-pinhole SPECT. IEEE transactions on nuclear science, 60(1), . https://doi.org/10.1109/TNS.2012.2214235
Ma, Dan, et al. "The performance of MLEM for dynamic imaging from simulated few-view, multi-pinhole SPECT." IEEE transactions on nuclear science vol. 60,1 (2013). doi: https://doi.org/10.1109/TNS.2012.2214235
Ma D, Wolf P, Clough AV, Schmidt TG. The performance of MLEM for dynamic imaging from simulated few-view, multi-pinhole SPECT. IEEE Trans Nucl Sci. 2013 Feb;60(1). doi: 10.1109/TNS.2012.2214235. PMID: 24273334; PMCID: PMC3835826.
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IEEE Trans Nucl Sci. 2013 Feb;60(1). doi: 10.1109/TNS.2012.2214235.

The performance of MLEM for dynamic imaging from simulated few-view, multi-pinhole SPECT.

IEEE transactions on nuclear science

Dan Ma, Paul Wolf, Anne V Clough, Taly Gilat Schmidt

Affiliations

  1. Department of Biomedical Engineering, Case Western University, Cleveland, OH 44105 and formerly with the Department of Biomedical Engineering, Marquette University, Milwaukee, WI, 53201, ( [email protected] ).

PMID: 24273334 PMCID: PMC3835826 DOI: 10.1109/TNS.2012.2214235

Abstract

Stationary small-animal SPECT systems are being developed for rapid dynamic imaging from limited angular views. This paper quantified, through simulations, the performance of Maximum Likelihood Expectation Maximization (MLEM) for reconstructing a time-activity curve (TAC) with uptake duration of a few seconds from a stationary, three-camera multi-pinhole SPECT system. The study also quantified the benefits of a heuristic method of initializing the reconstruction with a prior image reconstructed from a conventional number of views, for example from data acquired during the late-study portion of the dynamic TAC. We refer to MLEM reconstruction initialized by a prior-image initial guess (IG) as MLEM

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