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Kocoglu H, Alan C, Cakır DU, et al. Association between serum inhibin-B levels and coronary artery disease in aging males. Arch Med Sci. 2013;9(5):796-801doi: 10.5114/aoms.2013.34410.
Kocoglu, H., Alan, C., Cakır, D. U., Malkoc, E., Cosansu, K., Kırılmaz, B., Ertung, Y., & Ersay, A. R. (2013). Association between serum inhibin-B levels and coronary artery disease in aging males. Archives of medical science : AMS, 9(5), 796-801. https://doi.org/10.5114/aoms.2013.34410
Kocoglu, Hasan, et al. "Association between serum inhibin-B levels and coronary artery disease in aging males." Archives of medical science : AMS vol. 9,5 (2013): 796-801. doi: https://doi.org/10.5114/aoms.2013.34410
Kocoglu H, Alan C, Cakır DU, Malkoc E, Cosansu K, Kırılmaz B, Ertung Y, Ersay AR. Association between serum inhibin-B levels and coronary artery disease in aging males. Arch Med Sci. 2013 Oct 31;9(5):796-801. doi: 10.5114/aoms.2013.34410. Epub 2013 Apr 09. PMID: 24273559; PMCID: PMC3832817.
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Arch Med Sci. 2013 Oct 31;9(5):796-801. doi: 10.5114/aoms.2013.34410. Epub 2013 Apr 09.

Association between serum inhibin-B levels and coronary artery disease in aging males.

Archives of medical science : AMS

Hasan Kocoglu, Cabir Alan, Dilek Ulker Cakır, Ercan Malkoc, Kahraman Cosansu, Bahadır Kırılmaz, Yunus Ertung, Ahmet Resit Ersay

Affiliations

  1. Department of Urology, Canakkale Military Hospital, Turkey.

PMID: 24273559 PMCID: PMC3832817 DOI: 10.5114/aoms.2013.34410

Abstract

INTRODUCTION: Atherosclerosis is a systemic disorder. It is a frequent leading cause of coronary artery disease (CAD). Similarly, atherosclerotic vascular alterations could lead to testicular arterial blood flow reduction and impairment of testicular function with age. Inhibin-B has been validated as a valuable serum marker of testicular functions and its correlation with testicular volume was shown in some studies done before. The purpose of this study is to investigate the association between serum inhibin-B levels and CAD in elderly men.

MATERIAL AND METHODS: Between March 2009 and March 2010, fifty-two 50-80-year-old consecutive patients with Gensini score over 20 and ejection fraction (EF) > 50% were included in the study as the CAD group. Fifty healthy men without any cardiac disease history were recruited as the control group. All patients in the CAD group who had indications for coronary artery angiography underwent selective coronary artery angiography.

RESULTS: Inhibin-B, total testosterone and testicular volume levels were found to be significantly lower in the CAD group in comparison with the control group (p = 0.004, p < 0.0001, and p = 0.001 respectively).

CONCLUSIONS: In this study, although no correlation was found in CAD patients between Gensini score and inhibin-B or testicular volume, inhibin-B levels and testicular volume were significantly lower in patients with CAD than in healthy men. In order to fully assess the relationship between serum inhibin-B levels and CAD, multi-centered prospective and longitudinal studies must be done in elderly male patients.

Keywords: coronary artery disease; inhibin-B

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