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Oelusarz A, Nichols LA, Grunz-Borgmann EA, et al. Overexpression of MMP-7 Increases Collagen 1A2 in the Aging Kidney. Physiol Rep. 2013;1(5)doi: 10.1002/phy2.90.
Oelusarz, A., Nichols, L. A., Grunz-Borgmann, E. A., Chen, G., Akintola, A. D., Catania, J. M., Burghardt, R. C., Trzeciakowski, J. P., & Parrish, A. R. (2013). Overexpression of MMP-7 Increases Collagen 1A2 in the Aging Kidney. Physiological reports, 1(5), . https://doi.org/10.1002/phy2.90
Oelusarz, Anna, et al. "Overexpression of MMP-7 Increases Collagen 1A2 in the Aging Kidney." Physiological reports vol. 1,5 (2013). doi: https://doi.org/10.1002/phy2.90
Oelusarz A, Nichols LA, Grunz-Borgmann EA, Chen G, Akintola AD, Catania JM, Burghardt RC, Trzeciakowski JP, Parrish AR. Overexpression of MMP-7 Increases Collagen 1A2 in the Aging Kidney. Physiol Rep. 2013 Oct;1(5). doi: 10.1002/phy2.90. PMID: 24273653; PMCID: PMC3834982.
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Physiol Rep. 2013 Oct;1(5). doi: 10.1002/phy2.90.

Overexpression of MMP-7 Increases Collagen 1A2 in the Aging Kidney.

Physiological reports

Anna Oelusarz, Lanita A Nichols, Elizabeth A Grunz-Borgmann, Gang Chen, Adebayo D Akintola, Jeffery M Catania, Robert C Burghardt, Jerome P Trzeciakowski, Alan R Parrish

Affiliations

  1. Medical Pharmacology and Physiology, School of Medicine, University of Missouri.

PMID: 24273653 PMCID: PMC3834982 DOI: 10.1002/phy2.90

Abstract

The percentage of the U.S. population over 65 is rapidly increasing, as is the incidence of chronic kidney disease (CKD). The kidney is susceptible to age-dependent alterations in structure, specifically tubulointerstitial fibrosis, that lead to CKD. Matrix metalloproteinases (MMPs) were initially characterized as extracellular matrix (ECM) proteinases; however it is clear that their biological role is much larger. We have observed increased gene expression of several MMPs in the aging kidney, including MMP-7. MMP-7 overexpression was observed starting at 16 months, and over a 500 fold up-regulation in 2 year-old animals. Overexpression of MMP-7 is not observed in age-matched, calorically restricted controls that do not develop fibrosis and renal dysfunction, suggesting a role in the pathogenesis. In order to delineate the contributions of MMP-7 to renal dysfunction, we overexpressed MMP-7 in NRK-52E cells. High-throughput sequencing of the cells revealed that two collagen genes,

Keywords: Aging; Collagen; Fibrosis; MMP-7

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