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Masi AT, Rehman AA, Chatterton RT, et al. Controlled Cohort Study of Serum Gonadal and Adrenocortical Steroid Levels in Males Prior to Onset of Rheumatoid Arthritis (pre-RA): A Comparison to pre-RA Females and Sex Differences among the Study Groups. Int J Rheumatol. 2013;2013:284145doi: 10.1155/2013/284145.
Masi, A. T., Rehman, A. A., Chatterton, R. T., Wang, H., Goertzen, N. J., Elmore, K. B., & Aldag, J. C. (2013). Controlled Cohort Study of Serum Gonadal and Adrenocortical Steroid Levels in Males Prior to Onset of Rheumatoid Arthritis (pre-RA): A Comparison to pre-RA Females and Sex Differences among the Study Groups. International journal of rheumatology, 2013284145. https://doi.org/10.1155/2013/284145
Masi, Alfonse T, et al. "Controlled Cohort Study of Serum Gonadal and Adrenocortical Steroid Levels in Males Prior to Onset of Rheumatoid Arthritis (pre-RA): A Comparison to pre-RA Females and Sex Differences among the Study Groups." International journal of rheumatology vol. 2013 (2013): 284145. doi: https://doi.org/10.1155/2013/284145
Masi AT, Rehman AA, Chatterton RT, Wang H, Goertzen NJ, Elmore KB, Aldag JC. Controlled Cohort Study of Serum Gonadal and Adrenocortical Steroid Levels in Males Prior to Onset of Rheumatoid Arthritis (pre-RA): A Comparison to pre-RA Females and Sex Differences among the Study Groups. Int J Rheumatol. 2013;2013:284145. doi: 10.1155/2013/284145. Epub 2013 Nov 24. PMID: 24371442; PMCID: PMC3859165.
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Int J Rheumatol. 2013;2013:284145. doi: 10.1155/2013/284145. Epub 2013 Nov 24.

Controlled Cohort Study of Serum Gonadal and Adrenocortical Steroid Levels in Males Prior to Onset of Rheumatoid Arthritis (pre-RA): A Comparison to pre-RA Females and Sex Differences among the Study Groups.

International journal of rheumatology

Alfonse T Masi, Azeem A Rehman, Robert T Chatterton, Huaping Wang, Ned J Goertzen, Kevin B Elmore, Jean C Aldag

Affiliations

  1. Medicine and Epidemiology, College of Medicine (UICOMP), University of Illinois, Peoria, IL 61656, USA ; Department of Medicine, UICOMP, One Illini Drive, Peoria, IL 61656, USA.
  2. University of Illinois College of Medicine at Peoria (UICOMP), Peoria, IL 61656, USA.
  3. Northwestern University, Chicago, IL 60611, USA.
  4. Department of Medicine, UICOMP, One Illini Drive, Peoria, IL 61656, USA.

PMID: 24371442 PMCID: PMC3859165 DOI: 10.1155/2013/284145

Abstract

Serum testosterone levels are generally reported to be lower in male rheumatoid arthritis (RA) patients, but it is not determined if a deficiency may occur before clinical onset of disease (pre-RA). Lower testosterone levels were recently reported in males many years before RA onset but were predictive only of rheumatoid factor (RF)-negative disease. A preceding prospective study did not reveal androgenic-anabolic hormone association with risk of RA in men or women. This cohort study of males analyzed baseline serum levels of gonadal and adrenocortical steroids, luteinizing hormone, and prolactin in 18 pre-RA versus 72 matched non-RA control (CN) subjects. Findings in males were compared to those in female pre-RA and CN subjects in the same cohort, and sex differences were analyzed. Steroidal and hormonal levels, including total testosterone, were similar between male study groups. In females, mean (±SE) serum androstenedione (nmol/L) was slightly (P = 0.048) lower in 36 pre-RA (6.7 ± 0.36) than 144 CN (7.6 ± 0.22). With the exception of 3 partial correlations of hormonal variables observed to differ between pre-RA versus CN subjects, the patterns were similar overall. However, partial correlations of hormonal variables differed frequently by sex, both within and between study groups.

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