Display options
Cite
Ribeiro MD, Silva AS, Bailey KM, et al. Buffer Therapy for Cancer. J Nutr Food Sci. 2012;2:6
Ribeiro, M. D., Silva, A. S., Bailey, K. M., Kumar, N. B., Sellers, T. A., Gatenby, R. A., Ibrahim-Hashim, A., & Gillies, R. J. (2012). Buffer Therapy for Cancer. Journal of nutrition & food sciences, 26.
Ribeiro, Maria de Lourdes C, et al. "Buffer Therapy for Cancer." Journal of nutrition & food sciences vol. 2 (2012): 6.
Ribeiro MD, Silva AS, Bailey KM, Kumar NB, Sellers TA, Gatenby RA, Ibrahim-Hashim A, Gillies RJ. Buffer Therapy for Cancer. J Nutr Food Sci. 2012 Aug 15;2:6. PMID: 24371544; PMCID: PMC3872072.
Copy Download .nbib Format: NLM
Share it on

J Nutr Food Sci. 2012 Aug 15;2:6.

Buffer Therapy for Cancer.

Journal of nutrition & food sciences

Maria de Lourdes C Ribeiro, Ariosto S Silva, Kate M Bailey, Nagi B Kumar, Thomas A Sellers, Robert A Gatenby, Arig Ibrahim-Hashim, Robert J Gillies

Affiliations

  1. Department of Cancer Imaging and Metabolism, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612 ; Department of Molecular Medicine, Biotechnology M.S. Program, University of South Florida, Tampa, FL 33612.
  2. Department of Cancer Imaging and Metabolism, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612.
  3. Department of Cancer Imaging and Metabolism, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612 ; Department of Cell Biology, Microbiology, and Molecular Biology, Cancer Biology Ph.D. Program, University of South Florida, Tampa, FL 33612.
  4. Department of Epidemiology and Population Sciences Division, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612.
  5. Departent of Radiology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612.
  6. Department of Cancer Imaging and Metabolism, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612 ; Departent of Radiology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612.

PMID: 24371544 PMCID: PMC3872072

Abstract

Oral administration of pH buffers can reduce the development of spontaneous and experimental metastases in mice, and has been proposed in clinical trials. Effectiveness of buffer therapy is likely to be affected by diet, which could contribute or interfere with the therapeutic alkalinizing effect. Little data on food pH buffering capacity was available. This study evaluated the pH and buffering capacity of different foods to guide prospective trials and test the effect of the same buffer (lysine) at two different ionization states. Food groups were derived from the Harvard Food Frequency Questionnaire. Foods were blended and pH titrated with acid from initial pH values until 4.0 to determine "buffering score", in mmol H

Keywords: Food buffering capacity; acid-base; metastasis; pH; sodium bicarbonate

References

  1. Clin Nutr. 2011 Aug;30(4):416-21 - PubMed
  2. Keio J Med. 2006 Sep;55(3):96-106 - PubMed
  3. Meat Sci. 2000 Sep;56(1):7-13 - PubMed
  4. NMR Biomed. 2011 Jul;24(6):582-91 - PubMed
  5. Cancer Res. 2007 Aug 15;67(16):7638-45 - PubMed
  6. Eur J Clin Invest. 1983 Dec;13(6):455-60 - PubMed
  7. S Afr Med J. 2006 Jan;96(1):57-61 - PubMed
  8. Clin Exp Metastasis. 2011 Dec;28(8):841-9 - PubMed
  9. Am J Clin Nutr. 2009 Sep;90(3):826S-831S - PubMed
  10. Acta Physiol (Oxf). 2011 Jan;201(1):85-95 - PubMed
  11. J Gen Physiol. 1927 Mar 7;8(6):519-30 - PubMed
  12. Gut. 1966 Aug;7(4):344-50 - PubMed
  13. News Physiol Sci. 2001 Feb;16:23-8 - PubMed
  14. Br J Cancer. 1991 Oct;64(4):663-70 - PubMed
  15. Ann Surg Oncol. 2011 Nov;18(12):3338-52 - PubMed
  16. Nutr J. 2011 Apr 30;10:41 - PubMed
  17. World J Gastroenterol. 2010 Nov 21;16(43):5496-501 - PubMed
  18. Cancer Res. 2009 Mar 15;69(6):2677-84 - PubMed
  19. Gut. 1984 Apr;25(4):386-92 - PubMed
  20. Cell. 2011 Mar 4;144(5):646-74 - PubMed
  21. J Environ Public Health. 2012;2012:727630 - PubMed
  22. J Nucl Med. 2010 Aug;51(8):1167-70 - PubMed
  23. Scand J Clin Lab Invest. 1965;17(4):305-10 - PubMed
  24. Cancer Res. 2009 Mar 15;69(6):2260-8 - PubMed
  25. J Cancer Sci Ther. 2011 Nov 19;Suppl 1(4): - PubMed
  26. Am J Clin Nutr. 2003 May;77(5):1255-60 - PubMed
  27. J Clin Gastroenterol. 2002 Jul;35(1):5-8 - PubMed
  28. Digestion. 1995;56(2):100-6 - PubMed
  29. J Am Coll Nutr. 2011 Oct;30(5 Suppl 1):464S-70S - PubMed
  30. J Theor Biol. 2005 Aug 21;235(4):476-84 - PubMed
  31. Acta Pharm Hung. 2002;72(3):185-90 - PubMed
  32. Gastroenterology. 1968 Nov;55(5):567-74 - PubMed
  33. Annu Rev Med. 1978;29:99-116 - PubMed
  34. Pharm Res. 1990 Jul;7(7):756-61 - PubMed
  35. J Nucl Med. 2008 Jun;49 Suppl 2:24S-42S - PubMed
  36. Scand J Gastroenterol Suppl. 1986;124:113-20 - PubMed
  37. Clin Nutr. 2012 Jun;31(3):313-21 - PubMed
  38. Nat Rev Cancer. 2011 May;11(5):325-37 - PubMed
  39. J Magn Reson Imaging. 2007 May;25(5):992-9 - PubMed
  40. Cancer Res. 2006 May 15;66(10):5216-23 - PubMed
  41. Cancer Metastasis Rev. 2010 Sep;29(3):483-502 - PubMed
  42. Nutr J. 2009 Sep 15;8:41 - PubMed
  43. J Am Diet Assoc. 1995 Jul;95(7):791-7 - PubMed

Publication Types

Grant support