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Al-Abd NM, Nor ZM, Al-Adhroey AH, et al. Recent advances on the use of biochemical extracts as filaricidal agents. Evid Based Complement Alternat Med. 2013;2013:986573doi: 10.1155/2013/986573.
Al-Abd, N. M., Nor, Z. M., Al-Adhroey, A. H., Suhaimi, A., & Sivanandam, S. (2013). Recent advances on the use of biochemical extracts as filaricidal agents. Evidence-based complementary and alternative medicine : eCAM, 2013986573. https://doi.org/10.1155/2013/986573
Al-Abd, Nazeh M, et al. "Recent advances on the use of biochemical extracts as filaricidal agents." Evidence-based complementary and alternative medicine : eCAM vol. 2013 (2013): 986573. doi: https://doi.org/10.1155/2013/986573
Al-Abd NM, Nor ZM, Al-Adhroey AH, Suhaimi A, Sivanandam S. Recent advances on the use of biochemical extracts as filaricidal agents. Evid Based Complement Alternat Med. 2013;2013:986573. doi: 10.1155/2013/986573. Epub 2013 Nov 05. PMID: 24298292; PMCID: PMC3835708.
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Evid Based Complement Alternat Med. 2013;2013:986573. doi: 10.1155/2013/986573. Epub 2013 Nov 05.

Recent advances on the use of biochemical extracts as filaricidal agents.

Evidence-based complementary and alternative medicine : eCAM

Nazeh M Al-Abd, Zurainee Mohamed Nor, Abdulelah H Al-Adhroey, Anwar Suhaimi, S Sivanandam

Affiliations

  1. Department of Parasitology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.

PMID: 24298292 PMCID: PMC3835708 DOI: 10.1155/2013/986573

Abstract

Lymphatic filariasis is a parasitic infection that causes a devastating public health and socioeconomic burden with an estimated infection of over 120 million individuals worldwide. The infection is caused by three closely related nematode parasites, namely, Wuchereria bancrofti, Brugia malayi, and B. timori, which are transmitted to human through mosquitoes of Anopheles, Culex, and Aedes genera. The species have many ecological variants and are diversified in terms of their genetic fingerprint. The rapid spread of the disease and the genetic diversification cause the lymphatic filarial parasites to respond differently to diagnostic and therapeutic interventions. This in turn prompts the current challenge encountered in its management. Furthermore, most of the chemical medications used are characterized by adverse side effects. These complications urgently warrant intense prospecting on bio-chemicals that have potent efficacy against either the filarial worms or thier vector. In lieu of this, we presented a review on recent literature that reported the efficacy of filaricidal biochemicals and those employed as vector control agents. In addition, methods used for biochemical extraction, screening procedures, and structure of the bioactive compounds were also presented.

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