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Riad H, Mansour K, Sada HA, et al. Fatal metastatic cutaneous squamous cell carcinoma evolving from a localized verrucous epidermal nevus. Case Rep Dermatol. 2013;5(3):272-82doi: 10.1159/000355605.
Riad, H., Mansour, K., Sada, H. A., Naama, K. A., Shaigy, A. A., & Hussain, K. (2013). Fatal metastatic cutaneous squamous cell carcinoma evolving from a localized verrucous epidermal nevus. Case reports in dermatology, 5(3), 272-82. https://doi.org/10.1159/000355605
Riad, Hassan, et al. "Fatal metastatic cutaneous squamous cell carcinoma evolving from a localized verrucous epidermal nevus." Case reports in dermatology vol. 5,3 (2013): 272-82. doi: https://doi.org/10.1159/000355605
Riad H, Mansour K, Sada HA, Naama KA, Shaigy AA, Hussain K. Fatal metastatic cutaneous squamous cell carcinoma evolving from a localized verrucous epidermal nevus. Case Rep Dermatol. 2013 Oct 05;5(3):272-82. doi: 10.1159/000355605. eCollection 2013. PMID: 24403890; PMCID: PMC3884180.
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Case Rep Dermatol. 2013 Oct 05;5(3):272-82. doi: 10.1159/000355605. eCollection 2013.

Fatal metastatic cutaneous squamous cell carcinoma evolving from a localized verrucous epidermal nevus.

Case reports in dermatology

Hassan Riad, Khaled Mansour, Hussein Al Sada, Khalifa Al Naama, Amal Al Shaigy, Khairunnisa Hussain

Affiliations

  1. Rumailah Hospital, Doha, Qatar.

PMID: 24403890 PMCID: PMC3884180 DOI: 10.1159/000355605

Abstract

A malignant transformation is known to occur in many nevi such as a sebaceous nevus or a basal cell nevus, but a verrucous epidermal nevus has only rarely been associated with neoplastic changes. Keratoacanthoma, multifocal papillary apocrine adenoma, multiple malignant eccrine poroma, basal cell carcinoma and cutaneous squamous cell carcinoma (CSCC) have all been reported to develop from a verrucous epidermal nevus. CSCC has also been reported to arise from other nevoid lesions like a nevus comedonicus, porokeratosis, a sebaceous nevus, an oral sponge nevus and an ichthyosiform nevus with CHILD syndrome. Here we report a case of progressive poorly differentiated CSCC arising from a localized verrucous epidermal nevus, which caused both spinal cord and brain metastasis.

Keywords: Cutaneous squamous cell carcinoma; Epidermal nevus; Fatal metastatic cutaneous squamous cell carcinoma; Localized verrucous epidermal nevus; Metastasis

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