Display options
Cite
Kondo T, Sasaki K, Adachi H, et al. Heat shock treatment with mild electrical stimulation safely reduced inflammatory markers in healthy male subjects. Obes Res Clin Pract. 2010;4(2):e83-e162doi: 10.1016/j.orcp.2009.09.007.
Kondo, T., Sasaki, K., Adachi, H., Nakayama, Y., Hatemura, M., Matsuyama, R., Tsuruzoe, K., Furukawa, N., Motoshima, H., Morino Koga, S., Yamashita, Y., Miyamura, N., Kai, H., & Araki, E. (2010). Heat shock treatment with mild electrical stimulation safely reduced inflammatory markers in healthy male subjects. Obesity research & clinical practice, 4(2), e83-e162. https://doi.org/10.1016/j.orcp.2009.09.007
Kondo, Tatsuya, et al. "Heat shock treatment with mild electrical stimulation safely reduced inflammatory markers in healthy male subjects." Obesity research & clinical practice vol. 4,2 (2010): e83-e162. doi: https://doi.org/10.1016/j.orcp.2009.09.007
Kondo T, Sasaki K, Adachi H, Nakayama Y, Hatemura M, Matsuyama R, Tsuruzoe K, Furukawa N, Motoshima H, Morino Koga S, Yamashita Y, Miyamura N, Kai H, Araki E. Heat shock treatment with mild electrical stimulation safely reduced inflammatory markers in healthy male subjects. Obes Res Clin Pract. 2010 Apr-Jun;4(2):e83-e162. doi: 10.1016/j.orcp.2009.09.007. PMID: 24345648.
Copy Download .nbib Format: NLM
Share it on

Obes Res Clin Pract. 2010 Apr-Jun;4(2):e83-e162. doi: 10.1016/j.orcp.2009.09.007.

Heat shock treatment with mild electrical stimulation safely reduced inflammatory markers in healthy male subjects.

Obesity research & clinical practice

Tatsuya Kondo, Kazunari Sasaki, Hironori Adachi, Yoshiharu Nakayama, Masahiro Hatemura, Rina Matsuyama, Kaku Tsuruzoe, Noboru Furukawa, Hiroyuki Motoshima, Saori Morino Koga, Yasuyuki Yamashita, Nobuhiro Miyamura, Hirofumi Kai, Eiichi Araki

Affiliations

  1. Department of Metabolic Medicine, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto 860-8556, Japan.
  2. Department of Metabolic Medicine, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto 860-8556, Japan. Electronic address:[email protected].

PMID: 24345648 DOI: 10.1016/j.orcp.2009.09.007

Abstract

OBJECTIVE: Obesity induces chronic inflammation, which contributes to the development and progression of insulin resistance, diabetes and atherosclerosis. We have recently shown that induction of heat shock protein 72 by mild electric current and thermo (MET) treatment in mouse model of type 2 diabetes ameliorated glucose homeostasis and insulin resistance accompanied by reduced adiposity. For clinical application of MET, we confirmed its safety in healthy subjects.

METHODS: MET was applied for 10 healthy Japanese male (12 V, 55 pulses/s, 30 min at 42 °C) twice a week for 8 weeks. Fat volume was measured by CT scan and several parameters were investigated.

RESULTS: MET did not induce any adverse effects nor muscle contraction/pain. There were no significant alterations in glucose homeostasis or insulin resistance. Visceral and subcutaneous fat volume showed a trend of decrease without significant difference (-3.9% and -4.3%, respectively), which were restored 8 weeks after withdrawal of MET. Interestingly, serum tumor necrosis factor-α (TNF-α: 0.91 ± 0.05 pg/mL vs. 0.67 ± 0.06 pg/mL; p = 0.006) and high sensitivity C-reactive protein (hs-CRP: 521.9 ± 73.9 ng/mL vs. 270.8 ± 43.7 ng/mL; p = 0.023) levels, both of which are associated with chronic inflammation, were significantly decreased.

CONCLUSION: MET may be beneficial for the reduction of an inflammatory response observed in diabetes and metabolic syndrome.

© 2010 Asian Oceanian Association for the Study of Obesity . Published by Elsevier Ltd. All rights reserved.

Publication Types