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Asher DE, Craig AB, Zaldivar A, et al. A dynamic, embodied paradigm to investigate the role of serotonin in decision-making. Front Integr Neurosci. 2013;7:78doi: 10.3389/fnint.2013.00078.
Asher, D. E., Craig, A. B., Zaldivar, A., Brewer, A. A., & Krichmar, J. L. (2013). A dynamic, embodied paradigm to investigate the role of serotonin in decision-making. Frontiers in integrative neuroscience, 778. https://doi.org/10.3389/fnint.2013.00078
Asher, Derrik E, et al. "A dynamic, embodied paradigm to investigate the role of serotonin in decision-making." Frontiers in integrative neuroscience vol. 7 (2013): 78. doi: https://doi.org/10.3389/fnint.2013.00078
Asher DE, Craig AB, Zaldivar A, Brewer AA, Krichmar JL. A dynamic, embodied paradigm to investigate the role of serotonin in decision-making. Front Integr Neurosci. 2013 Nov 21;7:78. doi: 10.3389/fnint.2013.00078. PMID: 24319413; PMCID: PMC3836187.
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Front Integr Neurosci. 2013 Nov 21;7:78. doi: 10.3389/fnint.2013.00078.

A dynamic, embodied paradigm to investigate the role of serotonin in decision-making.

Frontiers in integrative neuroscience

Derrik E Asher, Alexis B Craig, Andrew Zaldivar, Alyssa A Brewer, Jeffrey L Krichmar

Affiliations

  1. Cognitive Anteater Robotics Lab, Department of Cognitive Sciences, University of California Irvine, CA, USA.

PMID: 24319413 PMCID: PMC3836187 DOI: 10.3389/fnint.2013.00078

Abstract

Serotonin (5-HT) is a neuromodulator that has been attributed to cost assessment and harm aversion. In this review, we look at the role 5-HT plays in making decisions when subjects are faced with potential harmful or costly outcomes. We review approaches for examining the serotonergic system in decision-making. We introduce our group's paradigm used to investigate how 5-HT affects decision-making. In particular, our paradigm combines techniques from computational neuroscience, socioeconomic game theory, human-robot interaction, and Bayesian statistics. We will highlight key findings from our previous studies utilizing this paradigm, which helped expand our understanding of 5-HT's effect on decision-making in relation to cost assessment. Lastly, we propose a cyclic multidisciplinary approach that may aid in addressing the complexity of exploring 5-HT and decision-making by iteratively updating our assumptions and models of the serotonergic system through exhaustive experimentation.

Keywords: acute tryptophan depletion; adaptive agents; cognitive modeling; cost assessment; embodiment; game theory; human–robot interaction; serotonin

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