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Beg AA, Khan T, Antonia SJ. A new role for NFκB in immunosurveillance and its implications for cancer immunotherapy. Oncoimmunology. 2013;2(10):e25963doi: 10.4161/onci.25963.
Beg, A. A., Khan, T., & Antonia, S. J. (2013). A new role for NFκB in immunosurveillance and its implications for cancer immunotherapy. Oncoimmunology, 2(10), e25963. https://doi.org/10.4161/onci.25963
Beg, Amer A, et al. "A new role for NFκB in immunosurveillance and its implications for cancer immunotherapy." Oncoimmunology vol. 2,10 (2013): e25963. doi: https://doi.org/10.4161/onci.25963
Beg AA, Khan T, Antonia SJ. A new role for NFκB in immunosurveillance and its implications for cancer immunotherapy. Oncoimmunology. 2013 Oct 01;2(10):e25963. doi: 10.4161/onci.25963. Epub 2013 Aug 02. PMID: 24404421; PMCID: PMC3875605.
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Oncoimmunology. 2013 Oct 01;2(10):e25963. doi: 10.4161/onci.25963. Epub 2013 Aug 02.

A new role for NFκB in immunosurveillance and its implications for cancer immunotherapy.

Oncoimmunology

Amer A Beg, Tahira Khan, Scott J Antonia

Affiliations

  1. Department of Immunology; Moffitt Cancer Center; Tampa, FL USA.
  2. Department of Immunology; Moffitt Cancer Center; Tampa, FL USA ; Atta ur Rehman School of Applied Biosciences (ASAB); National University of Science and Technology (NUST); Islamabad, Pakistan.
  3. Department of Immunology; Moffitt Cancer Center; Tampa, FL USA ; Department of Thoracic Oncology; Moffitt Cancer Center; Tampa, FL USA.

PMID: 24404421 PMCID: PMC3875605 DOI: 10.4161/onci.25963

Abstract

The activation of NFκB in the tumor microenvironment is associated with inflammatory responses that promote disease progression. We have recently found that the activation of NFκB in the tumor also regulates T cell-mediated immune responses, hence actively participating in cancer immunosurveillance. These findings call for reassessment of the function of NFκB within neoplastic lesions and open novel perspectives for anticancer immunotherapy.

Keywords: Immunotherapy; NFκB; chemokines; immunosurveillance; inflammation; lung cancer

References

  1. Nature. 2009 Nov 5;462(7269):104-7 - PubMed
  2. Cancer Res. 2010 May 1;70(9):3537-46 - PubMed
  3. N Engl J Med. 2010 Aug 19;363(8):711-23 - PubMed
  4. Cancer Res. 2012 Aug 1;72(15):3735-43 - PubMed
  5. N Engl J Med. 2012 Jun 28;366(26):2443-54 - PubMed
  6. Nat Rev Immunol. 2006 Nov;6(11):836-48 - PubMed
  7. Nat Rev Immunol. 2005 Oct;5(10):749-59 - PubMed
  8. Trends Immunol. 2013 Feb;34(2):67-73 - PubMed
  9. J Clin Invest. 2013 Jun;123(6):2509-22 - PubMed
  10. Nature. 2006 May 25;441(7092):431-6 - PubMed

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