J Pharm Bioallied Sci. 2013 Oct;5(4):277-89. doi: 10.4103/0975-7406.120078.
Synthesis, antifungal activity, and QSAR studies of 1,6-dihydropyrimidine derivatives.
Journal of pharmacy & bioallied sciences
Chirag Rami, Laxmanbhai Patel, Chhaganbhai N Patel, Jayshree P Parmar
Affiliations
Affiliations
- Department of Pharmaceutical Chemistry, Shri Sarvajanik Pharmacy College, Mehsana, Gujarat, India.
PMID: 24302836
PMCID: PMC3831741 DOI: 10.4103/0975-7406.120078
Abstract
INTRODUCTION: A practical synthesis of pyrimidinone would be very helpful for chemists because pyrimidinone is found in many bioactive natural products and exhibits a wide range of biological properties. The biological significance of pyrimidine derivatives has led us to the synthesis of substituted pyrimidine.
MATERIALS AND METHODS: With the aim of developing potential antimicrobials, new series of 5-cyano-6-oxo-1,6-dihydro-pyrimidine derivatives namely 2-(5-cyano-6-oxo-4-substituted (aryl)-1,6-dihydropyrimidin-2-ylthio)-N-substituted (phenyl) acetamide (C1-C41) were synthesized and characterized by Fourier transform infrared spectroscopy (FTIR), mass analysis, and proton nuclear magnetic resonance ((1)H NMR). All the compounds were screened for their antifungal activity against Candida albicans (MTCC, 227).
RESULTS AND DISCUSSION: Quantitative structure activity relationship (QSAR) studies of a series of 1,6-dihydro-pyrimidine were carried out to study various structural requirements for fungal inhibition. Various lipophilic, electronic, geometric, and spatial descriptors were correlated with antifungal activity using genetic function approximation. Developed models were found predictive as indicated by their square of predictive regression values (r(2pred)) and their internal and external cross-validation. Study reveals that CHI_3_C, Molecular_SurfaceArea, and Jurs_DPSA_1 contributed significantly to the activity along with some electronic, geometric, and quantum mechanical descriptors.
CONCLUSION: A careful analysis of the antifungal activity data of synthesized compounds revealed that electron withdrawing substitution on N-phenyl acetamide ring of 1,6-dihydropyrimidine moiety possess good activity.
Keywords: 1; 6-dihydro-pyrimidine; antifungal activity; genetic function approximation; lack of fit; quantitative structure activity relationship
References
- Bioorg Med Chem. 2006 Jul 15;14(14):4834-41 - PubMed
- Eur J Med Chem. 2007 Sep;42(9):1211-7 - PubMed
- Eur J Med Chem. 2006 Feb;41(2):276-82 - PubMed
- Farmaco. 2001 Oct;56(10):741-8 - PubMed
- Bioorg Med Chem. 2005 Mar 1;13(5):1537-44 - PubMed
- Eur J Med Chem. 2003 Jan;38(1):89-100 - PubMed
- J Med Chem. 1997 Jun 6;40(12):1845-54 - PubMed
- Future Microbiol. 2009 Mar;4(2):131-44 - PubMed
- Br J Pharmacol. 1986 Mar;87(3):569-78 - PubMed
- Eur J Med Chem. 2012 Jul;53:41-51 - PubMed
- Am J Psychiatry. 1979 Sep;136(9):1184-7 - PubMed
- Org Biomol Chem. 2003 Mar 21;1(6):960-4 - PubMed
- J Antimicrob Chemother. 2004 Sep;54(3):648-53 - PubMed
- Bioorg Med Chem Lett. 2005 Aug 15;15(16):3737-43 - PubMed
- Bioorg Med Chem Lett. 2004 Jun 21;14(12):3283-90 - PubMed
- Bioorg Med Chem Lett. 2006 Oct 15;16(20):5389-91 - PubMed
- J Med Chem. 2006 Jul 13;49(14):4183-95 - PubMed
- Org Biomol Chem. 2006 Sep 7;4(17):3252-8 - PubMed
- Bioorg Med Chem. 2008 Feb 1;16(3):1150-61 - PubMed
- Eur J Med Chem. 2009 Feb;44(2):678-88 - PubMed
- Expert Opin Investig Drugs. 2007 Sep;16(9):1441-8 - PubMed
- Bioorg Med Chem. 2003 Nov 17;11(23):4933-40 - PubMed
- Eur J Med Chem. 2005 Apr;40(4):401-5 - PubMed
- Bioorg Med Chem. 2007 Dec 1;15(23):7399-407 - PubMed
- Eur J Med Chem. 2008 Dec;43(12):2717-23 - PubMed
- Boll Chim Farm. 2003 Nov;142(9):396-405 - PubMed
- Bioorg Chem. 2006 Feb;34(1):26-38 - PubMed
- Eur J Clin Pharmacol. 1975 Apr 4;8(3-4):223-6 - PubMed
- Bioorg Med Chem Lett. 2000 Apr 17;10(8):703-6 - PubMed
- Bioorg Med Chem Lett. 2007 Mar 1;17(5):1221-5 - PubMed
- J Pharm Biomed Anal. 2004 Jun 29;35(4):679-87 - PubMed
- Chem Biol Drug Des. 2008 May;71(5):447-463 - PubMed
- Eur J Med Chem. 2009 Jun;44(6):2651-4 - PubMed
- J Med Chem. 2008 Sep 25;51(18):5843-55 - PubMed
- Nihon Yakurigaku Zasshi. 1969 Jul 20;65(4):378-409 - PubMed
- Eur J Med Chem. 2005 Jun;40(6):607-13 - PubMed
- Bioorg Med Chem Lett. 2006 Jul 15;16(14):3809-12 - PubMed
- Lancet. 2005 Oct 22-28;366(9495):1435-42 - PubMed
- Bioorg Med Chem Lett. 1999 Jun 7;9(11):1477-80 - PubMed
- Eur J Pharm Sci. 2005 Jun;25(2-3):245-54 - PubMed
- Bioorg Med Chem. 2009 Sep 15;17(18):6590-605 - PubMed
- Eur J Pharmacol. 2000 Dec 15;409(3):301-12 - PubMed
- Cancer Chemother Pharmacol. 2005 Jun;55(6):541-51 - PubMed
- Chem Pharm Bull (Tokyo). 1996 Sep;44(9):1700-6 - PubMed
- Clin Infect Dis. 2005 Jan 1;40(1):100-7 - PubMed
- Bioorg Med Chem. 2001 Dec;9(12):3153-60 - PubMed
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