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Kim JW, Kim YK, Hwang JA, et al. Plasma Levels of IL-23 and IL-17 before and after Antidepressant Treatment in Patients with Major Depressive Disorder. Psychiatry Investig. 2013;10(3):294-9doi: 10.4306/pi.2013.10.3.294.
Kim, J. W., Kim, Y. K., Hwang, J. A., Yoon, H. K., Ko, Y. H., Han, C., Lee, H. J., Ham, B. J., & Lee, H. S. (2013). Plasma Levels of IL-23 and IL-17 before and after Antidepressant Treatment in Patients with Major Depressive Disorder. Psychiatry investigation, 10(3), 294-9. https://doi.org/10.4306/pi.2013.10.3.294
Kim, Jae-Won, et al. "Plasma Levels of IL-23 and IL-17 before and after Antidepressant Treatment in Patients with Major Depressive Disorder." Psychiatry investigation vol. 10,3 (2013): 294-9. doi: https://doi.org/10.4306/pi.2013.10.3.294
Kim JW, Kim YK, Hwang JA, Yoon HK, Ko YH, Han C, Lee HJ, Ham BJ, Lee HS. Plasma Levels of IL-23 and IL-17 before and after Antidepressant Treatment in Patients with Major Depressive Disorder. Psychiatry Investig. 2013 Sep;10(3):294-9. doi: 10.4306/pi.2013.10.3.294. Epub 2013 Sep 16. PMID: 24302954; PMCID: PMC3843023.
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Psychiatry Investig. 2013 Sep;10(3):294-9. doi: 10.4306/pi.2013.10.3.294. Epub 2013 Sep 16.

Plasma Levels of IL-23 and IL-17 before and after Antidepressant Treatment in Patients with Major Depressive Disorder.

Psychiatry investigation

Jae-Won Kim, Yong-Ku Kim, Jung-A Hwang, Ho-Kyoung Yoon, Young-Hoon Ko, Changsu Han, Heon-Jeong Lee, Byung-Joo Ham, Hong Seock Lee

Affiliations

  1. Department of Psychiatry, Korea University, College of Medicine, Ansan Hospital, Ansan, Republic of Korea.

PMID: 24302954 PMCID: PMC3843023 DOI: 10.4306/pi.2013.10.3.294

Abstract

OBJECTIVE: Cytokines are believed to have a role in the pathophysiology of major depression. The alteration in levels of pro-inflammatory cytokines [interleukin 1β (IL-1β), IL-2, IL-6, IL-12, interferon γ, and tumor necrosis factor α] in major depression supports the cytokine hypothesis of this illness. IL-23 and IL-17 are also pro-inflammatory cytokines, but few studies have focused on their role in major depression. This study investigated the potential role of the IL-23 and IL-17 axis in major depression.

METHODS: Plasma IL-23 and IL-17 levels were measured in 26 major depressive disorder (MDD) patients before and after 6-week treatment with antidepressants; these levels were measured in 28 age- and sex-matched normal controls. Depression severity was assessed using the Hamilton Depression Rating Scale (HDRS). IL-23 and IL-17 plasma levels were estimated using quantitative enzyme-linked immunosorbent assay.

RESULTS: Pre-treatment plasma levels of IL-23 and IL-17 in MDD patients were not significantly different from those of normal controls. In MDD patients, IL-23 and IL-17 levels after 6 weeks of antidepressant treatment were not different from the baseline levels. There was no significant correlation between changes in the cytokine levels and changes in the HDRS scores representing the severity of depression.

CONCLUSION: The present study does not support a potential involvement of IL-23 and IL-17 axis in major depression. Replication and extension using a larger sample are required.

Keywords: Cytokine; IL-17; IL-23; Immune; Major depressive disorder; Th17 cell

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