Display options
Cite
Heffernan KS, Lefferts WK, Kasprowicz AG, et al. Manipulation of arterial stiffness, wave reflections, and retrograde shear rate in the femoral artery using lower limb external compression. Physiol Rep. 2013;1(2):e00022doi: 10.1002/phy2.22.
Heffernan, K. S., Lefferts, W. K., Kasprowicz, A. G., Tarzia, B. J., Thijssen, D. H., & Brutsaert, T. D. (2013). Manipulation of arterial stiffness, wave reflections, and retrograde shear rate in the femoral artery using lower limb external compression. Physiological reports, 1(2), e00022. https://doi.org/10.1002/phy2.22
Heffernan, Kevin S, et al. "Manipulation of arterial stiffness, wave reflections, and retrograde shear rate in the femoral artery using lower limb external compression." Physiological reports vol. 1,2 (2013): e00022. doi: https://doi.org/10.1002/phy2.22
Heffernan KS, Lefferts WK, Kasprowicz AG, Tarzia BJ, Thijssen DH, Brutsaert TD. Manipulation of arterial stiffness, wave reflections, and retrograde shear rate in the femoral artery using lower limb external compression. Physiol Rep. 2013 Jul;1(2):e00022. doi: 10.1002/phy2.22. Epub 2013 Jul 08. PMID: 24303111; PMCID: PMC3831918.
Copy Download .nbib Format: NLM
Share it on

Physiol Rep. 2013 Jul;1(2):e00022. doi: 10.1002/phy2.22. Epub 2013 Jul 08.

Manipulation of arterial stiffness, wave reflections, and retrograde shear rate in the femoral artery using lower limb external compression.

Physiological reports

Kevin S Heffernan, Wesley K Lefferts, Ari G Kasprowicz, Brendan J Tarzia, Dick H Thijssen, Tom D Brutsaert

Affiliations

  1. Department of Exercise Science, Syracuse University Syracuse, New York.

PMID: 24303111 PMCID: PMC3831918 DOI: 10.1002/phy2.22

Abstract

Exposure of the arterial wall to retrograde shear acutely leads to endothelial dysfunction and chronically contributes to a proatherogenic vascular phenotype. Arterial stiffness and increased pressure from wave reflections are known arbiters of blood flow in the systemic circulation and each related to atherosclerosis. Using distal external compression of the calf to increase upstream retrograde shear in the superficial femoral artery (SFA), we examined the hypothesis that changes in retrograde shear are correlated with changes in SFA stiffness and pressure from wave reflections. For this purpose, a pneumatic cuff was applied to the calf and inflated to 0, 35, and 70 mmHg (5 min compression, randomized order, separated by 5 min) in 16 healthy young men (23 ± 1 years of age). Doppler ultrasound and wave intensity analysis was used to measure SFA retrograde shear rate, reflected pressure wave intensity (negative area [NA]), elastic modulus (Ep), and a single-point pulse wave velocity (PWV) during acute cuff inflation. Cuff inflation resulted in stepwise increases in retrograde shear rate (P < 0.05 for main effect). There were also significant cuff pressure-dependent increases in NA, Ep, and PWV across conditions (P < 0.05 for main effects). Change in NA, but not Ep or PWV, was associated with change in retrograde shear rate across conditions (P < 0.05). In conclusion, external compression of the calf increases retrograde shear, arterial stiffness, and pressure from wave reflection in the upstream SFA in a dose-dependent manner. Wave reflection intensity, but not arterial stiffness, is correlated with changes in peripheral retrograde shear with this hemodynamic manipulation.

Keywords: Arterial stiffness; hemodynamics; intima-media thickness; wave reflections

References

  1. Arterioscler Thromb Vasc Biol. 1999 Dec;19(12):2933-9 - PubMed
  2. Circulation. 1990 Jul;82(1):114-23 - PubMed
  3. Atherosclerosis. 2010 Aug;211(2):390-2 - PubMed
  4. J Appl Physiol (1985). 2011 Mar;110(3):738-45 - PubMed
  5. Hypertension. 2010 Nov;56(5):920-5 - PubMed
  6. J Biomech Eng. 1995 Feb;117(1):127-35 - PubMed
  7. Hypertension. 2012 Oct;60(4):1016-22 - PubMed
  8. Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1833-9 - PubMed
  9. J Hypertens. 2008 Jul;26(7):1321-7 - PubMed
  10. Circ Res. 1980 Mar;46(3):363-72 - PubMed
  11. Clin Exp Pharmacol Physiol. 2001 Dec;28(12):1025-31 - PubMed
  12. J Hypertens. 1995 Sep;13(9):943-52 - PubMed
  13. Eur J Appl Physiol. 2007 Dec;101(6):735-41 - PubMed
  14. J Hypertens. 2001 Jun;19(6):1037-44 - PubMed
  15. Am J Physiol Heart Circ Physiol. 2010 Apr;298(4):H1126-7 - PubMed
  16. Blood Press Monit. 2003 Feb;8(1):27-30 - PubMed
  17. Am J Hypertens. 2002 Jan;15(1 Pt 1):24-30 - PubMed
  18. Circulation. 1996 Dec 15;94(12):3257-62 - PubMed
  19. Am J Physiol Heart Circ Physiol. 2000 Sep;279(3):H1007-14 - PubMed
  20. Heart Vessels. 2003 Jul;18(3):107-11 - PubMed
  21. Circ Res. 1990 Jun;66(6):1624-35 - PubMed
  22. Hypertension. 2013 Jan;61(1):143-50 - PubMed
  23. Cardiovasc Res. 1977 Sep;11(5):254-60 - PubMed
  24. J Appl Physiol (1985). 2010 Aug;109(2):484-90 - PubMed
  25. Hypertension. 2011 Jun;57(6):1145-50 - PubMed
  26. Pflugers Arch. 1975 Oct 16;360(1):63-79 - PubMed
  27. Exp Physiol. 2005 Jul;90(4):437-46 - PubMed
  28. Psychosom Med. 2001 Sep-Oct;63(5):788-96 - PubMed
  29. Heart Vessels. 2002 Nov;17(1):12-21 - PubMed
  30. Heart Vessels. 2002 Dec;17(2):61-8 - PubMed
  31. Appl Physiol Nutr Metab. 2013 Mar;38(3):268-74 - PubMed
  32. J Appl Physiol (1985). 2012 May;112(10):1653-8 - PubMed
  33. Hypertension. 2011 Mar;57(3):484-9 - PubMed
  34. Hypertension. 2010 Nov;56(5):926-33 - PubMed
  35. Proc Inst Mech Eng H. 2008 May;222(4):531-42 - PubMed
  36. J Am Coll Cardiol. 2001 Nov 15;38(6):1668-74 - PubMed
  37. Am J Physiol Heart Circ Physiol. 2009 Sep;297(3):H1103-8 - PubMed
  38. Eur J Appl Physiol. 2008 Apr;102(6):633-41 - PubMed
  39. Med Biol Eng Comput. 2009 Feb;47(2):197-206 - PubMed
  40. Blood Press Monit. 2010 Feb;15(1):55-8 - PubMed
  41. Hypertension. 2009 Jun;53(6):986-92 - PubMed
  42. J Appl Physiol (1985). 1995 Nov;79(5):1531-9 - PubMed
  43. Angiology. 1984 May;35(5):269-75 - PubMed
  44. Med Biol Eng Comput. 2009 Feb;47(2):207-10 - PubMed
  45. Circulation. 1985 Dec;72(6):1257-69 - PubMed
  46. Am J Physiol Heart Circ Physiol. 2010 Apr;298(4):H1128-35 - PubMed
  47. Eur J Appl Physiol. 2008 Jul;103(5):539-43 - PubMed
  48. Physiol Rev. 2011 Jan;91(1):327-87 - PubMed
  49. Heart Vessels. 2011 Mar;26(2):214-21 - PubMed
  50. Am J Physiol Heart Circ Physiol. 2005 Jul;289(1):H270-6 - PubMed
  51. Acta Physiol Scand Suppl. 1991;603:85-92 - PubMed
  52. Am J Physiol. 1996 Nov;271(5 Pt 2):H1807-13 - PubMed
  53. J Physiol. 2000 May 15;525 Pt 1:263-70 - PubMed
  54. Heart Vessels. 2002 Mar;16(3):91-8 - PubMed
  55. Cardiovasc Res. 1972 Nov;6(6):648-56 - PubMed
  56. Circ Cardiovasc Imaging. 2010 Sep;3(5):578-85 - PubMed
  57. Cardiovasc Res. 1970 Oct;4(4):405-17 - PubMed
  58. Hypertension. 2009 Aug;54(2):278-85 - PubMed

Publication Types