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Gaggin HK, Dec GW. The Role of Treatment for Anemia as a Therapeutic Target in the Management of Chronic Heart Failure: Insights After RED-HF. Curr Treat Options Cardiovasc Med. 2014;16(1):279doi: 10.1007/s11936-013-0279-9.
Gaggin, H. K., & Dec, G. W. (2014). The Role of Treatment for Anemia as a Therapeutic Target in the Management of Chronic Heart Failure: Insights After RED-HF. Current treatment options in cardiovascular medicine, 16(1), 279. https://doi.org/10.1007/s11936-013-0279-9
Gaggin, Hanna K, and Dec, G William. "The Role of Treatment for Anemia as a Therapeutic Target in the Management of Chronic Heart Failure: Insights After RED-HF." Current treatment options in cardiovascular medicine vol. 16,1 (2014): 279. doi: https://doi.org/10.1007/s11936-013-0279-9
Gaggin HK, Dec GW. The Role of Treatment for Anemia as a Therapeutic Target in the Management of Chronic Heart Failure: Insights After RED-HF. Curr Treat Options Cardiovasc Med. 2014 Jan;16(1):279. doi: 10.1007/s11936-013-0279-9. PMID: 24346853.
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Curr Treat Options Cardiovasc Med. 2014 Jan;16(1):279. doi: 10.1007/s11936-013-0279-9.

The Role of Treatment for Anemia as a Therapeutic Target in the Management of Chronic Heart Failure: Insights After RED-HF.

Current treatment options in cardiovascular medicine

Hanna K Gaggin, G William Dec

Affiliations

  1. Cardiology Division, Massachusetts General Hospital, Yawkey 5B, 55 Fruit Street, Boston, MA, 02114, USA, [email protected].

PMID: 24346853 DOI: 10.1007/s11936-013-0279-9

Abstract

OPINION STATEMENT: Anemia is common in patients with heart failure (HF) and appears to be closely linked with HF prognosis. A variety of mechanisms have been implicated in the association between anemia and HF, and treatment of anemia as a therapeutic target in HF patients is gaining increased attention. Recently large randomized controlled trials of erythropoietin-stimulating agents (ESA) and intravenous iron supplementation therapy have been completed and shed light on treatment of anemia in HF patients. ESA therapy did not show improvement in clinical outcomes, but intravenous iron supplementation may be of benefit in improving HF symptoms. Anemia has been commonly reported in patients with chronic heart failure (HF) and its prevalence appears to be closely linked with the severity of HF. Furthermore, the presence of anemia in patients with HF has been consistently associated with poor prognosis. Despite an increasing number of studies evaluating the relationship between HF and anemia, the answer to whether anemia is simply a marker or a mediator of poor prognosis in HF patients remains uncertain. One approach to this pivotal question has been to investigate treatment for anemia as a therapeutic target in HF.

References

  1. Circulation. 2008 Jan 29;117(4):526-35 - PubMed
  2. Circulation. 2003 Jan 21;107(2):226-9 - PubMed
  3. J Am Coll Cardiol. 2008 Feb 5;51(5):569-76 - PubMed
  4. Circulation. 2003 Jan 21;107(2):223-5 - PubMed
  5. Circ J. 2010 Feb;74(2):301-6 - PubMed
  6. J Am Coll Cardiol. 2007 Oct 16;50(16):1561-9 - PubMed
  7. J Am Coll Cardiol. 2008 Sep 2;52(10):818-27 - PubMed
  8. N Engl J Med. 2005 Mar 10;352(10):1011-23 - PubMed
  9. J Am Coll Cardiol. 2004 Jul 7;44(1):63-7 - PubMed
  10. Am J Med. 2008 Nov;121(11):943-8 - PubMed
  11. Eur J Heart Fail. 2003 Jan;5(1):3-4 - PubMed
  12. Int J Cardiol. 2013 Oct 9;168(4):3439-42 - PubMed
  13. J Card Fail. 2009 Nov;15(9):727-35 - PubMed
  14. J Am Coll Cardiol. 2004 Sep 1;44(5):959-66 - PubMed
  15. Am Heart J. 2006 Dec;152(6):1096.e9-15 - PubMed
  16. Circulation. 2005 Sep 6;112(10):1428-34 - PubMed
  17. J Am Coll Cardiol. 2008 Jan 15;51(2):103-12 - PubMed
  18. J Card Fail. 2009 Dec;15(10):843-9 - PubMed
  19. Am Heart J. 2011 May;161(5):822-831.e2 - PubMed
  20. Hematology Am Soc Hematol Educ Program. 2010;2010:338-47 - PubMed
  21. J Am Coll Cardiol. 1995 May;25(6):1402-7 - PubMed
  22. J Clin Invest. 1945 May;24(3):332-6 - PubMed
  23. Eur Heart J. 2007 Sep;28(18):2208-16 - PubMed
  24. Circulation. 2010 Jan 19;121(2):245-51 - PubMed
  25. J Nephrol. 2008 Mar-Apr;21(2):236-42 - PubMed
  26. Circulation. 2003 Jan 21;107(2):294-9 - PubMed
  27. Respir Physiol. 1987 May;68(2):215-25 - PubMed
  28. Circulation. 2001 Apr 24;103(16):2055-9 - PubMed
  29. J Am Coll Cardiol. 2006 Sep 19;48(6):1225-7 - PubMed
  30. J Am Soc Nephrol. 2002 Jul;13(7):1928-36 - PubMed
  31. Circulation. 2007 Apr 17;115(15):2022-32 - PubMed
  32. J Am Coll Cardiol. 2002 Jun 5;39(11):1780-6 - PubMed
  33. Arch Intern Med. 2005 Jun 13;165(11):1304-9 - PubMed
  34. Int J Cardiol. 2010 Feb 4;138(3):306-7 - PubMed
  35. J Cardiovasc Pharmacol. 2005 Aug;46(2):155-61 - PubMed
  36. J Am Coll Cardiol. 2001 Jun 1;37(7):1775-80 - PubMed
  37. JAMA. 1998 Jan 21;279(3):217-21 - PubMed
  38. Circulation. 1989 Aug;80(2):299-305 - PubMed
  39. Circ Res. 2007 Mar 16;100(5):662-9 - PubMed
  40. Blood. 2006 Mar 1;107(5):1747-50 - PubMed
  41. N Engl J Med. 2013 Mar 28;368(13):1210-9 - PubMed
  42. Am J Med. 2003 Feb 1;114(2):112-9 - PubMed
  43. J Am Coll Cardiol. 2001 Oct;38(4):955-62 - PubMed
  44. Clin Pharmacol Ther. 1993 Jul;54(1):84-9 - PubMed
  45. Circulation. 2005 Sep 20;112(12):1743-7 - PubMed
  46. Am J Hematol. 2011 Jan;86(1):107-9 - PubMed
  47. J Am Coll Cardiol. 1996 Apr;27(5):1201-6 - PubMed
  48. N Engl J Med. 2009 Nov 19;361(21):2019-32 - PubMed
  49. J Interferon Cytokine Res. 1998 Aug;18(8):555-9 - PubMed
  50. Am Heart J. 2004 May;147(5):924-30 - PubMed
  51. J Am Coll Cardiol. 2007 Feb 20;49(7):753-62 - PubMed
  52. N Engl J Med. 2009 Dec 17;361(25):2436-48 - PubMed
  53. J Am Coll Cardiol. 2011 Sep 13;58(12):1241-51 - PubMed
  54. Lancet. 2002 Feb 23;359(9307):663-6 - PubMed
  55. Nephrol Dial Transplant. 2002;17 Suppl 11:39-43 - PubMed
  56. J Paediatr Child Health. 1999 Apr;35(2):153-8 - PubMed
  57. Ann Intern Med. 1971 Jan;74(1):44-6 - PubMed
  58. J Am Coll Cardiol. 2000 Jun;35(7):1737-44 - PubMed
  59. Am J Cardiol. 1994 Sep 1;74(5):468-73 - PubMed
  60. Eur Heart J. 2008 Oct;29(19):2343-50 - PubMed
  61. Am Heart J. 2007 Oct;154(4):645.e9-15 - PubMed
  62. J Am Coll Cardiol. 2005 Feb 1;45(3):391-9 - PubMed
  63. Am Heart J. 2008 Apr;155(4):751.e1-7 - PubMed
  64. J Am Coll Cardiol. 2006 Dec 19;48(12):2485-9 - PubMed
  65. Eur Heart J. 2010 Aug;31(15):1872-80 - PubMed
  66. Br Heart J. 1993 Oct;70(4):357-62 - PubMed
  67. J Am Coll Cardiol. 2007 Oct 23;50(17):1657-65 - PubMed
  68. Lab Invest. 1975 Apr;32(4):503-14 - PubMed
  69. Eur J Cardiovasc Prev Rehabil. 2008 Jun;15(3):365-9 - PubMed
  70. J Card Fail. 2012 Oct;18(10):784-91 - PubMed
  71. Eur Heart J. 2005 Nov;26(21):2232-7 - PubMed

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