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Wangtrakuldee P, Byrd MS, Campos CG, et al. Discovery of Inhibitors of . ACS Med Chem Lett. 2013;4(8)doi: 10.1021/ml400034m.
Wangtrakuldee, P., Byrd, M. S., Campos, C. G., Henderson, M. W., Zhang, Z., Clare, M., Masoudi, A., Myler, P. J., Horn, J. R., Cotter, P. A., & Hagen, T. J. (2013). Discovery of Inhibitors of . ACS medicinal chemistry letters, 4(8), . https://doi.org/10.1021/ml400034m
Wangtrakuldee, Phumvadee, et al. "Discovery of Inhibitors of ." ACS medicinal chemistry letters vol. 4,8 (2013). doi: https://doi.org/10.1021/ml400034m
Wangtrakuldee P, Byrd MS, Campos CG, Henderson MW, Zhang Z, Clare M, Masoudi A, Myler PJ, Horn JR, Cotter PA, Hagen TJ. Discovery of Inhibitors of . ACS Med Chem Lett. 2013 Jul 01;4(8). doi: 10.1021/ml400034m. PMID: 24376907; PMCID: PMC3871185.
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ACS Med Chem Lett. 2013 Jul 01;4(8). doi: 10.1021/ml400034m.

Discovery of Inhibitors of .

ACS medicinal chemistry letters

Phumvadee Wangtrakuldee, Matthew S Byrd, Cristine G Campos, Michael W Henderson, Zheng Zhang, Michael Clare, Ali Masoudi, Peter J Myler, James R Horn, Peggy A Cotter, Timothy J Hagen

Affiliations

  1. Department of Chemistry and Biochemistry, Northern Illinois University, 1425 West Lincoln Highway, DeKalb, Illinois 60115-2828, United States.
  2. Department of Microbiology and Immunology, University of North Carolina, 116 Manning Drive, Chapel Hill, North Carolina 27599, United States.
  3. Clare Associates LLC, 5154 West Brown Street, Skokie, Illinois 60077, United States.

PMID: 24376907 PMCID: PMC3871185 DOI: 10.1021/ml400034m

Abstract

Evaluation of a series of MetAP inhibitors in an in vitro enzyme activity assay led to the first identification of potent molecules that show significant growth inhibition against Burkholderia pseudomallei. Nitroxoline analogs show excellent inhibition potency in the BpMetAP1 enzyme activity assay with the lowest IC

Keywords: BpMetAP1; Burkholderia pseudomallei; melioidosis; methionine aminopeptidase inhibitor

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