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Hole P, Sillence K, Hannell C, et al. Interlaboratory comparison of size measurements on nanoparticles using nanoparticle tracking analysis (NTA). J Nanopart Res. 2013;15:2101doi: 10.1007/s11051-013-2101-8.
Hole, P., Sillence, K., Hannell, C., Maguire, C. M., Roesslein, M., Suarez, G., Capracotta, S., Magdolenova, Z., Horev-Azaria, L., Dybowska, A., Cooke, L., Haase, A., Contal, S., Manø, S., Vennemann, A., Sauvain, J. J., Staunton, K. C., Anguissola, S., Luch, A., Dusinska, M., Korenstein, R., Gutleb, A. C., Wiemann, M., Prina-Mello, A., Riediker, M., & Wick, P. (2013). Interlaboratory comparison of size measurements on nanoparticles using nanoparticle tracking analysis (NTA). Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology, 152101. https://doi.org/10.1007/s11051-013-2101-8
Hole, Patrick, et al. "Interlaboratory comparison of size measurements on nanoparticles using nanoparticle tracking analysis (NTA)." Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology vol. 15 (2013): 2101. doi: https://doi.org/10.1007/s11051-013-2101-8
Hole P, Sillence K, Hannell C, Maguire CM, Roesslein M, Suarez G, Capracotta S, Magdolenova Z, Horev-Azaria L, Dybowska A, Cooke L, Haase A, Contal S, Manø S, Vennemann A, Sauvain JJ, Staunton KC, Anguissola S, Luch A, Dusinska M, Korenstein R, Gutleb AC, Wiemann M, Prina-Mello A, Riediker M, Wick P. Interlaboratory comparison of size measurements on nanoparticles using nanoparticle tracking analysis (NTA). J Nanopart Res. 2013;15:2101. doi: 10.1007/s11051-013-2101-8. Epub 2013 Nov 19. PMID: 24348090; PMCID: PMC3857864.
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J Nanopart Res. 2013;15:2101. doi: 10.1007/s11051-013-2101-8. Epub 2013 Nov 19.

Interlaboratory comparison of size measurements on nanoparticles using nanoparticle tracking analysis (NTA).

Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology

Patrick Hole, Katherine Sillence, Claire Hannell, Ciaran Manus Maguire, Matthias Roesslein, Guillaume Suarez, Sonja Capracotta, Zuzana Magdolenova, Limor Horev-Azaria, Agnieszka Dybowska, Laura Cooke, Andrea Haase, Servane Contal, Stein Manø, Antje Vennemann, Jeans-Jacques Sauvain, Kieran Crosbie Staunton, Sergio Anguissola, Andreas Luch, Maria Dusinska, Rafi Korenstein, Arno C Gutleb, Martin Wiemann, Adriele Prina-Mello, Michael Riediker, Peter Wick

Affiliations

  1. NanoSight Ltd., Minton Park, London Road, Amesbury, Wiltshire, SP4 7RT UK.
  2. Trinity Centre for Health Sciences, Department of Clinical Medicine, Institute of Molecular Medicine, St. James's Hospital, James Street, Dublin 8, Ireland.
  3. Laboratory for Materials - Biology Interactions, Swiss Federal Laboratories for Materials Research and Testing (Empa), Lerchenfeldstrasse 5, 9014 St Gallen, Switzerland.
  4. Institute for Work and Health, Rte. de la Corniche 2, 1066 Epalinges-Lausanne, Switzerland.
  5. NanoSight USA, 1415 Washington Heights, Rm 6611, Ann Arbor, MI 48109 USA.
  6. Health Effects Laboratory, Department of Environmental Chemistry, Norwegian Institute for Air Research, Instituttveien 18, P.O. Box 100, NO-2027 Kjeller, Norway.
  7. Department of Physiology and Pharmacology, Sackler School of Medicine, Tel Aviv University, 69978 Tel Aviv, Israel.
  8. Department of Earth Sciences, Natural History Museum, Cromwell Road, London, SW7 5BD UK.
  9. Centre for Bio-Nano Interactions (CBNI), University College Dublin, Belfield, Dublin 4, Ireland.
  10. Experimental Research, Department of Product Safety, Bundesinstitut fur Risikobewertung (BfR), Max-Dohrn-Strasse 8-10, 10589 Berlin, Germany.
  11. Département Environnement et Agro-biotechnologies (EVA), Centre de Recherche Public Gabriel Lippmann, 41, rue du Brill, 4422 Belvaux, Luxembourg.
  12. IBE R&D Institute for Lung Health gGmbH, Mendelstrasse 11, 48149 Münster, Germany.

PMID: 24348090 PMCID: PMC3857864 DOI: 10.1007/s11051-013-2101-8

Abstract

One of the key challenges in the field of nanoparticle (NP) analysis is in producing reliable and reproducible characterisation data for nanomaterials. This study looks at the reproducibility using a relatively new, but rapidly adopted, technique, Nanoparticle Tracking Analysis (NTA) on a range of particle sizes and materials in several different media. It describes the protocol development and presents both the data and analysis of results obtained from 12 laboratories, mostly based in Europe, who are primarily QualityNano members. QualityNano is an EU FP7 funded Research Infrastructure that integrates 28 European analytical and experimental facilities in nanotechnology, medicine and natural sciences with the goal of developing and implementing best practice and quality in all aspects of nanosafety assessment. This study looks at both the development of the protocol and how this leads to highly reproducible results amongst participants. In this study, the parameter being measured is the modal particle size.

Keywords: Health and safety implications; Interlaboratory comparison; Nanoparticle; Polydispersity; Reproducibility; Toxicology

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