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Maruyama K, Nagata K, Kojima K, et al. Intraocular Invasion of Adult T-Cell Leukemia Cells without Systemic Symptoms after Cataract Surgery. Case Rep Ophthalmol. 2013;4(3):252-6doi: 10.1159/000355486.
Maruyama, K., Nagata, K., Kojima, K., Inaba, T., Sugita, S., Mochizuki, M., & Kinoshita, S. (2013). Intraocular Invasion of Adult T-Cell Leukemia Cells without Systemic Symptoms after Cataract Surgery. Case reports in ophthalmology, 4(3), 252-6. https://doi.org/10.1159/000355486
Maruyama, Kazuichi, et al. "Intraocular Invasion of Adult T-Cell Leukemia Cells without Systemic Symptoms after Cataract Surgery." Case reports in ophthalmology vol. 4,3 (2013): 252-6. doi: https://doi.org/10.1159/000355486
Maruyama K, Nagata K, Kojima K, Inaba T, Sugita S, Mochizuki M, Kinoshita S. Intraocular Invasion of Adult T-Cell Leukemia Cells without Systemic Symptoms after Cataract Surgery. Case Rep Ophthalmol. 2013 Nov 16;4(3):252-6. doi: 10.1159/000355486. eCollection 2013. PMID: 24348412; PMCID: PMC3861856.
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Case Rep Ophthalmol. 2013 Nov 16;4(3):252-6. doi: 10.1159/000355486. eCollection 2013.

Intraocular Invasion of Adult T-Cell Leukemia Cells without Systemic Symptoms after Cataract Surgery.

Case reports in ophthalmology

Kazuichi Maruyama, Kenji Nagata, Kentaro Kojima, Toru Inaba, Sunao Sugita, Manabu Mochizuki, Shigeru Kinoshita

Affiliations

  1. Department of Ophthalmology and Visual Science, Tohoku University Graduate School of Medicine, Sendai, Japan ; Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
  2. Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
  3. Department of Clinical Laboratory and Medicinew, Kyoto Prefectural University of Medicine, Kyoto, Japan.
  4. RIKEN Center for Development Biology, Kobe, Japan.
  5. Department of Ophthalmology, Tokyo Dental and Medical University, Tokyo, Japan.

PMID: 24348412 PMCID: PMC3861856 DOI: 10.1159/000355486

Abstract

Adult T-cell leukemia (ATL) is an aggressive lymphoid proliferation associated with the human T-lymphotropic virus type I (HTLV-I). The intraocular invasion of ATL is a rare event. A 75-year-old man without any systemic disease underwent uneventful cataract surgery of the right eye. On postoperative day 6, the patient presented with blurred vision due to severe vitreous opacity in the right eye. Analysis of the vitreous fluid revealed a suspected ATL infection based on the flow cytometric analysis. Moreover, cytological examination of the vitreous specimen revealed flower cell infiltration, and HTLV-1 DNA was detected by PCR analysis of the vitreous sample. Monoclonal T-cell receptor chain rearrangement was also detected by PCR. Thorough analysis of a vitreous sample is essential for vitrectomy in vitreous opacity of unknown cause. Flow cytometric, cytological, and PCR analysis of vitreous samples is beneficial for determining the cause of this kind of severe illness.

Keywords: Adult T-cell leukemia; Flow cytometry; Intraocular invasion

References

  1. Br J Haematol. 1991 Nov;79(3):428-37 - PubMed
  2. Am J Ophthalmol. 2002 Oct;134(4):616-8 - PubMed
  3. Lancet Oncol. 2004 Nov;5(11):664-72 - PubMed
  4. Br J Ophthalmol. 2010 Mar;94(3):336-40 - PubMed
  5. Ophthalmology. 1993 Dec;100(12):1794-9 - PubMed
  6. Blood. 2002 Dec 1;100(12):4129-38 - PubMed
  7. Blood. 1977 Sep;50(3):481-92 - PubMed
  8. Br J Ophthalmol. 2006 Sep;90(9):1204-6 - PubMed
  9. Ophthalmology. 2012 Nov;119(11):2386-92 - PubMed
  10. Int J Hematol. 1999 Feb;69(2):92-5 - PubMed
  11. Invest Ophthalmol Vis Sci. 2012 Jun 20;53(7):3827-33 - PubMed
  12. Ann Hematol. 1997 Apr;74(4):163-8 - PubMed

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