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Togawa A, Uyama S, Takanohashi S, et al. Adjusted Anion Gap Is Associated with Glomerular Filtration Rate Decline in Chronic Kidney Disease. Nephron Extra. 2013;3(1):113-117doi: 10.1159/000356461.
Togawa, A., Uyama, S., Takanohashi, S., Shimasaki, M., Miyaji, T., Endo, H., & Fujigaki, Y. (2013). Adjusted Anion Gap Is Associated with Glomerular Filtration Rate Decline in Chronic Kidney Disease. Nephron extra, 3(1), 113-117. https://doi.org/10.1159/000356461
Togawa, Akashi, et al. "Adjusted Anion Gap Is Associated with Glomerular Filtration Rate Decline in Chronic Kidney Disease." Nephron extra vol. 3,1 (2013): 113-117. doi: https://doi.org/10.1159/000356461
Togawa A, Uyama S, Takanohashi S, Shimasaki M, Miyaji T, Endo H, Fujigaki Y. Adjusted Anion Gap Is Associated with Glomerular Filtration Rate Decline in Chronic Kidney Disease. Nephron Extra. 2013 Nov 14;3(1):113-117. doi: 10.1159/000356461. eCollection 2013. PMID: 24348507; PMCID: PMC3861847.
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Nephron Extra. 2013 Nov 14;3(1):113-117. doi: 10.1159/000356461. eCollection 2013.

Adjusted Anion Gap Is Associated with Glomerular Filtration Rate Decline in Chronic Kidney Disease.

Nephron extra

Akashi Togawa, Satoko Uyama, Seiko Takanohashi, Megumi Shimasaki, Takehiko Miyaji, Hiroyuki Endo, Yoshihide Fujigaki

Affiliations

  1. Department of Nephrology, Shizuoka Saiseikai General Hospital, Tokyo, Japan.
  2. Miyaji Clinic, Hamamatsu University School of Medicine, Hamamatsu, Tokyo, Japan.
  3. Tanpopo Clinic, Shizuoka, Hamamatsu University School of Medicine, Hamamatsu, Tokyo, Japan.
  4. Internal Medicine 1, Hamamatsu University School of Medicine, Hamamatsu, Tokyo, Japan ; Division of Nephrology, Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan.

PMID: 24348507 PMCID: PMC3861847 DOI: 10.1159/000356461

Abstract

BACKGROUND: Metabolic acidosis is known to accelerate the progression of chronic kidney disease (CKD). However, whether undetermined anions as indicated by the adjusted anion gap (aAG) are associated with estimated glomerular filtration rate (eGFR) decline in patients with CKD is unclear.

METHODS: Data from 42 patients with CKD (baseline eGFR, 7.1-52.0 ml/min/ 1.73 m

RESULTS: The mean baseline eGFR was 27.5 ± 11.1 ml/min/1.73 m

CONCLUSION: These data suggest that aAG appears to be associated with the progression of CKD. aAG might be an independent predictor of CKD progression.

Keywords: Adjusted anion gap; Chronic kidney disease; Glomerular filtration rate decline

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