Display options
Cite
Kulkarni J, Gavrilidis E, Worsley R, et al. The role of estrogen in the treatment of men with schizophrenia. Int J Endocrinol Metab. 2013;11(3):129-36doi: 10.5812/ijem.6615.
Kulkarni, J., Gavrilidis, E., Worsley, R., Van Rheenen, T., & Hayes, E. (2013). The role of estrogen in the treatment of men with schizophrenia. International journal of endocrinology and metabolism, 11(3), 129-36. https://doi.org/10.5812/ijem.6615
Kulkarni, Jayashri, et al. "The role of estrogen in the treatment of men with schizophrenia." International journal of endocrinology and metabolism vol. 11,3 (2013): 129-36. doi: https://doi.org/10.5812/ijem.6615
Kulkarni J, Gavrilidis E, Worsley R, Van Rheenen T, Hayes E. The role of estrogen in the treatment of men with schizophrenia. Int J Endocrinol Metab. 2013;11(3):129-36. doi: 10.5812/ijem.6615. Epub 2013 Jul 01. PMID: 24348584; PMCID: PMC3860106.
Copy Download .nbib Format: NLM
Share it on

Int J Endocrinol Metab. 2013;11(3):129-36. doi: 10.5812/ijem.6615. Epub 2013 Jul 01.

The role of estrogen in the treatment of men with schizophrenia.

International journal of endocrinology and metabolism

Jayashri Kulkarni, Emmy Gavrilidis, Roisin Worsley, Tamsyn Van Rheenen, Emily Hayes

Affiliations

  1. The Monash Alfred Psychiatry Research Centre, The Alfred and Monash University School of Psychology, Psychiatry and Psychological Medicine, Melbourne, Australia.

PMID: 24348584 PMCID: PMC3860106 DOI: 10.5812/ijem.6615

Abstract

Schizophrenia is a debilitating and pervasive mental illness with devastating effects on many aspects of psychological, cognitive and social wellbeing. Epidemiological and life-cycle data point to significant differences in the incidence and course of schizophrenia between men and women, suggesting that estrogen plays a "protective" role . Adjunctive estrogen therapy has been shown to be effective in enhancing the treatment of schizophrenia in women. In men, consideration of estrogen therapy has been impacted by concerns of feminisation, however, clinical trials using estrogen to treat prostate cancer, bone density loss and even aggression in men with dementia or traumatic brain injury, show estrogen to be a safe and effective therapy. Findings do, however, suggest that further exploration of a therapeutic role for adjunctive estradiol treatment in men with schizophrenia is warranted. The development of the new estrogen compounds - Selective Estrogen Receptor Modulators (SERMs) which do not cause feminisation - opens up the possibility of using a different type of estrogen for a longer period of time at higher doses. Estrogen could therefore prove to be an important component in the treatment of psychotic symptoms in men with schizophrenia. This review explains the scientific rationale behind the estrogen hypothesis and how it can be clinically utilised to address concerns unique to the care of men with schizophrenia.

Keywords: Estrogen; Men; Neuroprotection; Psychosis; Schizophrenia; Selective Estrogen Receptor Modulators

References

  1. Neurology. 2001 Jul 10;57(1):80-8 - PubMed
  2. Eur Arch Psychiatry Clin Neurosci. 1995;246(1):17-28 - PubMed
  3. Acta Psychiatr Scand Suppl. 2007;(434):41-9 - PubMed
  4. CNS Drugs. 2012 Jul 1;26(7):549-57 - PubMed
  5. Neurology. 1999 Apr 22;52(7):1417-21 - PubMed
  6. Eur Arch Psychiatry Neurol Sci. 1988 Sep;237(6):351-64 - PubMed
  7. Biol Psychiatry. 2000 Mar 15;47(6):562-76 - PubMed
  8. Arch Gen Psychiatry. 2008 Aug;65(8):955-60 - PubMed
  9. Eur J Endocrinol. 2011 Apr;164(4):635-42 - PubMed
  10. Urology. 2000 Mar;55(3):328-33 - PubMed
  11. Prog Neurobiol. 2001 Jun;64(3):251-67 - PubMed
  12. J Urol. 2001 Aug;166(2):517-20 - PubMed
  13. JAMA. 1999 Aug 18;282(7):637-45 - PubMed
  14. BMJ. 2009 Aug 13;339:b2890 - PubMed
  15. Aust N Z J Psychiatry. 2012 Sep;46(9):851-63 - PubMed
  16. Int J Womens Health. 2010 Aug 09;1:11-20 - PubMed
  17. N Engl J Med. 2012 Jun 14;366(24):2257-66 - PubMed
  18. Med J Aust. 2009 Feb 16;190(S4):S37-8 - PubMed
  19. Psychooncology. 2009 Mar;18(3):237-47 - PubMed
  20. Schizophr Res. 2011 Feb;125(2-3):278-83 - PubMed
  21. Aust N Z J Psychiatry. 1997 Feb;31(1):46-56 - PubMed
  22. Epidemiol Rev. 2008;30:67-76 - PubMed
  23. Brain Res. 1999 Nov 13;847(1):98-104 - PubMed
  24. Ann Neurol. 2003 May;53(5):607-15 - PubMed
  25. J Neurochem. 2001 Jun;77(5):1319-26 - PubMed
  26. Horm Res. 1997;48(4):155-63 - PubMed
  27. Eur Arch Psychiatry Clin Neurosci. 1993;242(6):323-8 - PubMed
  28. J Affect Disord. 2001 Sep;66(1):1-11 - PubMed
  29. Psychoneuroendocrinology. 2004 Sep;29(8):1071-81 - PubMed
  30. Psychoneuroendocrinology. 1990;15(2):97-111 - PubMed
  31. Psychol Med. 2007 Oct;37(10):1427-36 - PubMed
  32. J Neurosci. 1996 Nov 1;16(21):7021-9 - PubMed
  33. Schizophr Bull. 1994;20(2):287-96 - PubMed
  34. Schizophr Bull. 1990;16(2):185-94 - PubMed
  35. Am J Psychiatry. 2002 Jul;159(7):1225-7 - PubMed
  36. Climacteric. 2012 Jun;15(3):229-34 - PubMed
  37. Clin Psychol Rev. 2008 Oct;28(7):1188-205 - PubMed
  38. J Int Neuropsychol Soc. 2003 May;9(4):623-32 - PubMed
  39. Ann N Y Acad Sci. 2001 Dec;949:181-5 - PubMed
  40. J Gerontol A Biol Sci Med Sci. 2002 May;57(5):M321-5 - PubMed
  41. Schizophr Res. 2010 Dec;124(1-3):13-21 - PubMed
  42. Eur Arch Psychiatry Clin Neurosci. 1991;241(1):65-8 - PubMed
  43. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2006 Sep-Dec;13(3-4):291-307 - PubMed
  44. Horm Behav. 2004 Apr;45(4):250-8 - PubMed
  45. Neuropathology. 2007 Dec;27(6):604-8 - PubMed
  46. Lancet. 1996 Aug 17;348(9025):429-32 - PubMed
  47. CNS Drugs. 2001;15(10):797-817 - PubMed
  48. J Gerontol B Psychol Sci Soc Sci. 2000 Jan;55(1):P47-53 - PubMed
  49. J Alzheimers Dis. 2011;26(3):495-505 - PubMed
  50. J Clin Endocrinol Metab. 2006 Nov;91(11):4335-43 - PubMed
  51. Clin Neuropharmacol. 1998 Mar-Apr;21(2):118-21 - PubMed
  52. Arch Gen Psychiatry. 2004 Feb;61(2):162-7 - PubMed
  53. Aging Male. 2003 Mar;6(1):13-7 - PubMed
  54. Neurology. 1997 Jun;48(6):1517-21 - PubMed
  55. Neuroscience. 2007 Jun 29;147(2):334-41 - PubMed
  56. Clin Breast Cancer. 2002 Jun;3(2):153-9 - PubMed
  57. Obstet Gynecol. 2000 Jan;95(1):95-103 - PubMed
  58. Z Kinder Jugendpsychiatr Psychother. 1997 Dec;25(4):218-33 - PubMed
  59. Am J Psychiatry. 2001 Jul;158(7):1134-9 - PubMed
  60. Behav Neurosci. 1996 Jun;110(3):613-7 - PubMed
  61. J Urol. 2006 Jan;175(1):130-5 - PubMed
  62. Psychoneuroendocrinology. 2004 Apr;29(3):405-21 - PubMed
  63. Aust N Z J Psychiatry. 2008 Jan;42(1):74-82 - PubMed
  64. Schizophr Bull. 1998;24(1):99-113 - PubMed
  65. J Urol. 2003 May;169(5):1735-7 - PubMed
  66. Biol Psychiatry. 2006 Aug 1;60(3):288-95 - PubMed
  67. Verh K Acad Geneeskd Belg. 1999;61(3):441-52; discussion 453-5 - PubMed
  68. Psychoneuroendocrinology. 1999 Jan;24(1):115-28 - PubMed
  69. Neurobiol Aging. 2011 Oct;32(10):1808-17 - PubMed
  70. Am J Psychiatry. 2002 Mar;159(3):456-9 - PubMed
  71. Behav Brain Res. 1999 Nov 1;105(1):53-68 - PubMed
  72. Ann Neurol. 2006 Sep;60(3):346-55 - PubMed
  73. Mov Disord. 2000 Nov;15(6):1119-24 - PubMed
  74. Arch Neurol. 1994 Sep;51(9):896-900 - PubMed
  75. J Am Geriatr Soc. 2004 Feb;52(2):316-8 - PubMed
  76. J Psychiatry Neurosci. 2002 Jan;27(1):12-27 - PubMed
  77. Schizophr Bull. 1999;25(2):309-19 - PubMed
  78. Horm Behav. 2002 May;41(3):259-66 - PubMed
  79. J Psychiatr Res. 1988;22(2):141-55 - PubMed
  80. Psychiatry Res. 2002 Sep 15;112(1):41-50 - PubMed
  81. J Clin Endocrinol Metab. 2004 May;89(5):2085-98 - PubMed
  82. Arch Gen Psychiatry. 2008 Mar;65(3):283-9 - PubMed
  83. Psychoneuroendocrinology. 2010 Sep;35(8):1142-7 - PubMed
  84. Psychosom Med. 2011 Oct;73(8):643-7 - PubMed
  85. N Engl J Med. 2008 Aug 14;359(7):697-708 - PubMed
  86. Biol Psychiatry. 1995 Apr 1;37(7):434-41 - PubMed
  87. Psychoneuroendocrinology. 2005 May;30(4):309-15 - PubMed
  88. Neuropharmacology. 2002 Jun;42(8):1056-64 - PubMed
  89. Arch Gen Psychiatry. 2003 Jun;60(6):565-71 - PubMed
  90. Eur J Endocrinol. 2006 Dec;155(6):773-81 - PubMed
  91. J Clin Endocrinol Metab. 2000 Sep;85(9):3027-35 - PubMed
  92. Neurobiol Aging. 2007 Feb;28(2):171-8 - PubMed
  93. N Engl J Med. 1986 Sep 18;315(12):731-5 - PubMed
  94. Horm Behav. 1998 Oct;34(2):199-208 - PubMed
  95. Br J Psychiatry. 1994 May;164(5):625-9 - PubMed
  96. BMC Med. 2004 Apr 28;2:13 - PubMed
  97. Brain Res. 2003 May 16;972(1-2):1-8 - PubMed
  98. Synapse. 1987;1(2):133-52 - PubMed
  99. CNS Drug Rev. 2002 Fall;8(3):309-30 - PubMed
  100. J Neurol Neurosurg Psychiatry. 1990 Oct;53(10):915-7 - PubMed
  101. Am J Psychiatry. 2005 Apr;162(4):683-90 - PubMed
  102. Am J Epidemiol. 1994 Aug 1;140(3):256-61 - PubMed
  103. JAMA. 1999 Jun 16;281(23):2189-97 - PubMed
  104. Schizophr Bull. 1994;20(1):203-14 - PubMed
  105. Arch Neurol. 2002 Mar;59(3):385-9 - PubMed
  106. Schizophr Res. 2001 Mar 1;48(1):137-44 - PubMed
  107. Neuropsychobiology. 2006;53(4):169-75 - PubMed
  108. Neurology. 2005 Jan 25;64(2):290-6 - PubMed
  109. Psychoneuroendocrinology. 2006 May;31(4):543-7 - PubMed
  110. J Comp Neurol. 2007 Aug 20;503(6):790-802 - PubMed
  111. Arch Gen Psychiatry. 2007 Jan;64(1):19-28 - PubMed
  112. Psychoneuroendocrinology. 2003 Apr;28 Suppl 2:17-54 - PubMed
  113. Schizophr Res. 2009 Oct;114(1-3):17-24 - PubMed
  114. J Clin Psychiatry. 2006 Oct;67(10):e12 - PubMed
  115. Br J Psychiatry. 2009 Dec;195(6):475-82 - PubMed
  116. J Clin Endocrinol Metab. 2010 Jan;95(1):280-8 - PubMed
  117. Am J Geriatr Psychiatry. 1999 Fall;7(4):339-48 - PubMed
  118. Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):19198-203 - PubMed
  119. Int J Gynaecol Obstet. 1999 Apr;65(1):35-8 - PubMed
  120. Aust N Z J Psychiatry. 2003 Feb;37(1):31-40 - PubMed
  121. Horm Behav. 2010 Jan;57(1):2-11 - PubMed
  122. Cell Mol Neurobiol. 1996 Jun;16(3):325-44 - PubMed
  123. J Appl Physiol (1985). 2001 Dec;91(6):2785-801 - PubMed
  124. Psychoneuroendocrinology. 2003 Apr;28 Suppl 2:1-16 - PubMed
  125. Vitam Horm. 2010;82:xix-xx - PubMed
  126. Am J Obstet Gynecol. 2000 Aug;183(2):414-20 - PubMed
  127. Aust N Z J Psychiatry. 2000 Apr;34(2):221-36 - PubMed
  128. J Cogn Neurosci. 2000 May;12(3):407-14 - PubMed
  129. J Neurobiol. 2003 Mar;54(4):638-47 - PubMed
  130. Prog Neuropsychopharmacol Biol Psychiatry. 2003 Sep;27(6):1007-12 - PubMed
  131. Neurology. 1997 May;48(5 Suppl 7):S16-9 - PubMed
  132. Psychoneuroendocrinology. 1998 Aug;23(6):583-603 - PubMed

Publication Types