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Farhad SZ, Aminzadeh A, Mafi M, et al. The effect of adjunctive low-dose doxycycline and licorice therapy on gingival crevicular fluid matrix metalloproteinase-8 levels in chronic periodontitis. Dent Res J (Isfahan). 2013;10(5):624-9
Farhad, S. Z., Aminzadeh, A., Mafi, M., Barekatain, M., Naghney, M., & Ghafari, M. R. (2013). The effect of adjunctive low-dose doxycycline and licorice therapy on gingival crevicular fluid matrix metalloproteinase-8 levels in chronic periodontitis. Dental research journal, 10(5), 624-9.
Farhad, Shirin Zahra, et al. "The effect of adjunctive low-dose doxycycline and licorice therapy on gingival crevicular fluid matrix metalloproteinase-8 levels in chronic periodontitis." Dental research journal vol. 10,5 (2013): 624-9.
Farhad SZ, Aminzadeh A, Mafi M, Barekatain M, Naghney M, Ghafari MR. The effect of adjunctive low-dose doxycycline and licorice therapy on gingival crevicular fluid matrix metalloproteinase-8 levels in chronic periodontitis. Dent Res J (Isfahan). 2013 Sep;10(5):624-9. PMID: 24348620; PMCID: PMC3858737.
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Dent Res J (Isfahan). 2013 Sep;10(5):624-9.

The effect of adjunctive low-dose doxycycline and licorice therapy on gingival crevicular fluid matrix metalloproteinase-8 levels in chronic periodontitis.

Dental research journal

Shirin Zahra Farhad, Atousa Aminzadeh, Morvarid Mafi, Mehrdad Barekatain, Mohammad Naghney, Mohammad Reza Ghafari

Affiliations

  1. Department of Periodontics, Young Researchers Club, Isfahan, Iran.
  2. Department of Oral Pathology, Young Researchers Club, Isfahan, Iran.
  3. Department of Restorative Dentistry, Khorasgan Branch, Islamic Azad Dental School of Khorasgan, Isfahan, Iran.
  4. General Dentist, Private Practice, Isfahan, Iran.

PMID: 24348620 PMCID: PMC3858737

Abstract

BACKGROUND: This study compared the effect of adjunctive low dose doxycycline and licorice on gingival crevicular fluid (GCF) matrix metalloproteinase-8 (MMP-8) levels in patients with chronic periodontitis.

MATERIALS AND METHODS: In this in vivo, experimental study 39 patients with mild to moderate chronic periodontitis were selected. Samples of GCF were collected from three deepest pockets and MMP-8 concentration was measured. Patients were divided into three groups (n = 13). Groups were treated with doxycycline, licorice and placebo. Sampling and measurement of MMP-8 was repeated after 6 weeks. Data was analyzed by t-paired and ANOVA test. P > 0.001 was considered significant.

RESULTS: The decrease in mean of MMP-8 concentration was higher in doxycycline and licorice group in comparison with the placebo group and the difference was statistically significant (P value > 0.001). The decrease in mean of MMP-8 concentration was higher in licorice group than doxycycline group, but the difference was not statistically significant.

CONCLUSION: The present study showed that licorice extract can prevent the production of MMPs by host cells and can be as useful as antibiotics like doxycycline to cure periodontal and other inflammatory diseases. It must be added that no side-effects were observed in usage of licorice extract.

Keywords: Chronic periodontitis; doxycycline; gingival crevicular fluid; licorice; matrix metalloproteinase enzymes-8

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