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Yang N, Deutsch S, Paterson EG, et al. Comparative Study of Continuous and Pulsatile Left Ventricular Assist Devices on Hemodynamics of a Pediatric End-to-Side Anastomotic Graft. Cardiovasc Eng Technol. 2010;1(1)doi: 10.1007/s13239-010-0006-6.
Yang, N., Deutsch, S., Paterson, E. G., & Manning, K. B. (2010). Comparative Study of Continuous and Pulsatile Left Ventricular Assist Devices on Hemodynamics of a Pediatric End-to-Side Anastomotic Graft. Cardiovascular engineering and technology, 1(1), . https://doi.org/10.1007/s13239-010-0006-6
Yang, Ning, et al. "Comparative Study of Continuous and Pulsatile Left Ventricular Assist Devices on Hemodynamics of a Pediatric End-to-Side Anastomotic Graft." Cardiovascular engineering and technology vol. 1,1 (2010). doi: https://doi.org/10.1007/s13239-010-0006-6
Yang N, Deutsch S, Paterson EG, Manning KB. Comparative Study of Continuous and Pulsatile Left Ventricular Assist Devices on Hemodynamics of a Pediatric End-to-Side Anastomotic Graft. Cardiovasc Eng Technol. 2010 Mar;1(1). doi: 10.1007/s13239-010-0006-6. PMID: 24348881; PMCID: PMC3859142.
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Cardiovasc Eng Technol. 2010 Mar;1(1). doi: 10.1007/s13239-010-0006-6.

Comparative Study of Continuous and Pulsatile Left Ventricular Assist Devices on Hemodynamics of a Pediatric End-to-Side Anastomotic Graft.

Cardiovascular engineering and technology

Ning Yang, Steven Deutsch, Eric G Paterson, Keefe B Manning

Affiliations

  1. Department of Bioengineering, The Pennsylvania State University, University Park, PA 16802, USA.
  2. Department of Bioengineering, The Pennsylvania State University, University Park, PA 16802, USA ; The Applied Research Laboratory, The Pennsylvania State University, University Park, PA 16802, USA.
  3. The Applied Research Laboratory, The Pennsylvania State University, University Park, PA 16802, USA ; Department of Mechanical Engineering, The Pennsylvania State University, University Park, PA 16802, USA.

PMID: 24348881 PMCID: PMC3859142 DOI: 10.1007/s13239-010-0006-6

Abstract

Although there are many studies that focus on understanding the consequence of pumping mode (continuous vs. pulsatile) associated with ventricular assist devices (VADs) on pediatric vascular pulsatility, the impact on local hemodynamics has been largely ignored. Hence, we compare not only the hemodynamic parameters indicative of pulsatility but also the local flow fields in the aorta and the great vessels originating from the aortic arch. A physiologic graft anastomotic model is constructed based on a pediatric, patient specific, aorta with a graft attached on the ascending aorta. The flow is simulated using a previously validated second-order accurate Navier-Stokes flow solver based upon a finite volume approach. The major findings are: (1) pulsatile support provides a greater degree of vascular pulsatility when compared to continuous support, which, however, is still 20% less than pulsatility in the healthy aorta; (2) pulsatile support increases the flow in the great vessels, while continuous support decreases it; (3) complete VAD support results in turbulence in the aorta, with maximum principal Reynolds stresses for pulsatile support and continuous support of 7081 and 249 dyn/cm

Keywords: Anastomosis; Hemolysis; Oscillatory shear index; Reynolds stress; Wall shear stress

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