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d'Esterre CD, Tichauer KM, Aviv RI, et al. Dipyridamole Treatment Prior to Stroke Onset: Examining Post-stroke Cerebral Circulation and Outcome in Rabbits. Transl Stroke Res. 2011;2(2):186-94doi: 10.1007/s12975-010-0062-0.
d'Esterre, C. D., Tichauer, K. M., Aviv, R. I., Eisert, W., & Lee, T. Y. (2011). Dipyridamole Treatment Prior to Stroke Onset: Examining Post-stroke Cerebral Circulation and Outcome in Rabbits. Translational stroke research, 2(2), 186-94. https://doi.org/10.1007/s12975-010-0062-0
d'Esterre, Christopher D, et al. "Dipyridamole Treatment Prior to Stroke Onset: Examining Post-stroke Cerebral Circulation and Outcome in Rabbits." Translational stroke research vol. 2,2 (2011): 186-94. doi: https://doi.org/10.1007/s12975-010-0062-0
d'Esterre CD, Tichauer KM, Aviv RI, Eisert W, Lee TY. Dipyridamole Treatment Prior to Stroke Onset: Examining Post-stroke Cerebral Circulation and Outcome in Rabbits. Transl Stroke Res. 2011 Jun;2(2):186-94. doi: 10.1007/s12975-010-0062-0. Epub 2011 Jan 11. PMID: 24323622.
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Transl Stroke Res. 2011 Jun;2(2):186-94. doi: 10.1007/s12975-010-0062-0. Epub 2011 Jan 11.

Dipyridamole Treatment Prior to Stroke Onset: Examining Post-stroke Cerebral Circulation and Outcome in Rabbits.

Translational stroke research

Christopher D d'Esterre, Kenneth M Tichauer, Richard I Aviv, Wolfgang Eisert, Ting-Yim Lee

Affiliations

  1. The University of Western Ontario, London, ON, Canada, [email protected].

PMID: 24323622 DOI: 10.1007/s12975-010-0062-0

Abstract

Clinical observations have indicated that secondary treatment with dipyridamole (DIP) may ameliorate stroke severity. The purpose of this study was to explore the effect of pre-stroke DIP treatment on stroke outcome in a rabbit model of embolic occlusion. Twenty male New Zealand white rabbits were randomly selected for intravenous treatment with DIP (n = 10) or saline (n = 10) for 7 days prior to an embolic cerebral occlusion by an autologous blood clot. Multiple computed tomography perfusion scans were acquired out to 28 days post-stroke to map cerebrohemodynamics, in conjunction with neurological assessments and histopathology. The DIP-treated group fared better than the saline group on several accounts: 66% of them survived to 28 days, whilst saline animals all had to be euthanized by day 7 due to severe neurological deficits. They presented with significantly more viable tissue in the ischemic hemisphere as well as fewer neurological deficits on days 4 and 7. Furthermore, DIP-treated animals exhibited improved cerebrohemodynamics by 24 h and had less incidence of haemorrhage within their infarcted regions (p < 0.05). DIP treatment prior to stroke onset can significantly improve neurological outcome, cerebral hemodynamics, and final infarct volume.

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