Display options
Cite
Fortin JS, Cloutier M, Thibodeau J. Exposing the Specific Roles of the Invariant Chain Isoforms in Shaping the MHC Class II Peptidome. Front Immunol. 2013;4:443doi: 10.3389/fimmu.2013.00443.
Fortin, J. S., Cloutier, M., & Thibodeau, J. (2013). Exposing the Specific Roles of the Invariant Chain Isoforms in Shaping the MHC Class II Peptidome. Frontiers in immunology, 4443. https://doi.org/10.3389/fimmu.2013.00443
Fortin, Jean-Simon, et al. "Exposing the Specific Roles of the Invariant Chain Isoforms in Shaping the MHC Class II Peptidome." Frontiers in immunology vol. 4 (2013): 443. doi: https://doi.org/10.3389/fimmu.2013.00443
Fortin JS, Cloutier M, Thibodeau J. Exposing the Specific Roles of the Invariant Chain Isoforms in Shaping the MHC Class II Peptidome. Front Immunol. 2013 Dec 13;4:443. doi: 10.3389/fimmu.2013.00443. PMID: 24379812; PMCID: PMC3861868.
Copy Download .nbib Format: NLM
Share it on

Front Immunol. 2013 Dec 13;4:443. doi: 10.3389/fimmu.2013.00443.

Exposing the Specific Roles of the Invariant Chain Isoforms in Shaping the MHC Class II Peptidome.

Frontiers in immunology

Jean-Simon Fortin, Maryse Cloutier, Jacques Thibodeau

Affiliations

  1. Laboratoire d'Immunologie Moléculaire, Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal , Montréal, QC , Canada.

PMID: 24379812 PMCID: PMC3861868 DOI: 10.3389/fimmu.2013.00443

Abstract

The peptide repertoire (peptidome) associated with MHC class II molecules (MHCIIs) is influenced by the polymorphic nature of the peptide binding groove but also by cell-intrinsic factors. The invariant chain (Ii) chaperones MHCIIs, affecting their folding and trafficking. Recent discoveries relating to Ii functions have provided insights as to how it edits the MHCII peptidome. In humans, the Ii gene encodes four different isoforms for which structure-function analyses have highlighted common properties but also some non-redundant roles. Another layer of complexity arises from the fact that Ii heterotrimerizes, a characteristic that has the potential to affect the maturation of associated MHCIIs in many different ways, depending on the isoform combinations. Here, we emphasize the peptide editing properties of Ii and discuss the impact of the various isoforms on the MHCII peptidome.

Keywords: MHCII; MHCII trafficking; antigen presentation; di-arginine motif; di-leucine motif; invariant chain; p35

References

  1. Nature. 1995 Jun 15;375(6532):603-6 - PubMed
  2. J Cell Biol. 1991 Dec;115(5):1213-23 - PubMed
  3. Exp Cell Res. 1997 Aug 25;235(1):79-92 - PubMed
  4. J Immunol. 2008 Mar 1;180(5):3339-46 - PubMed
  5. Science. 1994 Mar 4;263(5151):1284-6 - PubMed
  6. Eur J Immunol. 1995 Jul;25(7):1851-6 - PubMed
  7. FEBS Lett. 2012 May 7;586(9):1318-24 - PubMed
  8. Science. 2008 Dec 12;322(5908):1705-10 - PubMed
  9. J Biol Chem. 1997 Mar 28;272(13):8281-7 - PubMed
  10. J Immunol. 1994 Aug 15;153(4):1487-94 - PubMed
  11. EMBO J. 1984 Apr;3(4):873-7 - PubMed
  12. Proc Natl Acad Sci U S A. 2005 May 31;102(22):7910-5 - PubMed
  13. J Immunol. 2003 Jan 1;170(1):620-7 - PubMed
  14. Annu Rev Cell Dev Biol. 1995;11:267-306 - PubMed
  15. Int Immunol. 2003 Oct;15(10):1249-63 - PubMed
  16. Annu Rev Immunol. 1994;12:259-93 - PubMed
  17. Biochem J. 2007 Aug 15;406(1):97-103 - PubMed
  18. Nature. 1991 Dec 5;354(6352):392-4 - PubMed
  19. Proc Natl Acad Sci U S A. 1998 Feb 3;95(3):1056-61 - PubMed
  20. Proc Natl Acad Sci U S A. 1982 Jan;79(1):175-8 - PubMed
  21. J Clin Invest. 2001 Oct;108(8):1133-9 - PubMed
  22. Cell Immunol. 1996 Jul 10;171(1):68-73 - PubMed
  23. J Immunol. 2004 Jul 15;173(2):1085-93 - PubMed
  24. Oncoimmunology. 2012 Sep 1;1(6):908-916 - PubMed
  25. Eur J Immunol. 1998 May;28(5):1524-33 - PubMed
  26. Curr Opin Immunol. 1992 Feb;4(1):87-92 - PubMed
  27. EMBO J. 2001 Aug 1;20(15):4055-64 - PubMed
  28. Adv Exp Med Biol. 1997;417:195-201 - PubMed
  29. J Exp Med. 2000 Mar 20;191(6):1057-62 - PubMed
  30. Immunology. 2004 Jul;112(3):378-85 - PubMed
  31. Eur J Immunol. 1995 Jan;25(1):48-53 - PubMed
  32. Immunol Cell Biol. 2012 Oct;90(9):896-902 - PubMed
  33. Proc Natl Acad Sci U S A. 1991 Jul 15;88(14):5998-6002 - PubMed
  34. J Biol Chem. 2005 May 20;280(20):19656-64 - PubMed
  35. Immunity. 1995 Sep;3(3):359-72 - PubMed
  36. J Biol Chem. 2002 May 10;277(19):16484-8 - PubMed
  37. Proc Natl Acad Sci U S A. 1991 Mar 15;88(6):2346-50 - PubMed
  38. Immunogenetics. 1985;21(1):83-90 - PubMed
  39. Proc Natl Acad Sci U S A. 1995 Aug 1;92(16):7217-21 - PubMed
  40. Immunity. 1995 Sep;3(3):373-83 - PubMed
  41. Immunology. 2010 Sep;131(1):18-32 - PubMed
  42. Curr Opin Immunol. 2002 Feb;14(1):30-5 - PubMed
  43. J Biol Chem. 2008 May 23;283(21):14453-60 - PubMed
  44. J Immunol. 1981 Nov;127(5):1869-75 - PubMed
  45. Cell. 1989 Feb 24;56(4):683-9 - PubMed
  46. Nature. 1990 Dec 13;348(6302):600-5 - PubMed
  47. Immunity. 1995 Jan;2(1):73-88 - PubMed
  48. J Immunol. 2008 Oct 15;181(8):5451-5461 - PubMed
  49. J Immunol. 2011 Sep 1;187(5):2442-52 - PubMed
  50. Semin Immunol. 1995 Dec;7(6):373-87 - PubMed
  51. J Immunol. 1998 Jun 15;160(12):5797-806 - PubMed
  52. Proc Natl Acad Sci U S A. 1995 Oct 24;92(22):10257-61 - PubMed
  53. EMBO J. 1992 Aug;11(8):2841-7 - PubMed
  54. Mol Cell Proteomics. 2012 Nov;11(11):1457-67 - PubMed
  55. Immunol Cell Biol. 2011 Jul;89(5):619-29 - PubMed
  56. Trends Immunol. 2003 May;24(5):264-8 - PubMed
  57. Proc Natl Acad Sci U S A. 1991 Apr 15;88(8):3014-8 - PubMed
  58. Immunity. 2000 Mar;12(3):233-9 - PubMed
  59. Curr Biol. 2003 Apr 15;13(8):638-46 - PubMed
  60. J Exp Med. 2013 Jan 14;210(1):41-58 - PubMed
  61. Trends Biochem Sci. 2007 Dec;32(12):532-7 - PubMed
  62. Immunity. 1997 Aug;7(2):197-208 - PubMed
  63. J Biol Chem. 2013 Aug 23;288(34):24286-92 - PubMed
  64. J Cell Biol. 1996 Apr;133(2):281-91 - PubMed
  65. J Immunol. 1992 Jun 1;148(11):3478-82 - PubMed
  66. Eur J Immunol. 2003 Feb;33(2):277-86 - PubMed
  67. Cell. 1982 May;29(1):61-9 - PubMed
  68. J Immunol. 2006 Dec 1;177(11):7588-98 - PubMed
  69. Immunity. 1999 Jun;10(6):761-8 - PubMed
  70. J Immunol. 1996 Mar 15;156(6):2133-42 - PubMed
  71. Nature. 1986 Aug 21-27;322(6081):687-9 - PubMed
  72. J Exp Med. 1993 Jun 1;177(6):1699-712 - PubMed
  73. World J Gastroenterol. 2009 Jun 21;15(23):2855-61 - PubMed
  74. EMBO J. 1994 Feb 1;13(3):675-82 - PubMed
  75. Trends Biochem Sci. 1997 Oct;22(10):377-82 - PubMed
  76. Cell. 1990 Nov 16;63(4):707-16 - PubMed
  77. PLoS One. 2011 Feb 22;6(2):e17257 - PubMed
  78. Nat Rev Immunol. 2013 Jul;13(7):475-86 - PubMed
  79. Nature. 1992 Jun 18;357(6379):596-8 - PubMed
  80. J Autoimmun. 2011 May;36(3-4):201-9 - PubMed
  81. J Cell Sci. 2005 Oct 15;118(Pt 20):4679-87 - PubMed
  82. Nat Cell Biol. 2011 Dec 22;14(1):20-8 - PubMed
  83. Nat Immunol. 2012 Feb 05;13(3):237-45 - PubMed
  84. Science. 1998 Apr 17;280(5362):450-3 - PubMed
  85. J Immunol. 1998 May 15;160(10):4850-8 - PubMed
  86. J Exp Med. 1995 May 1;181(5):1729-41 - PubMed
  87. J Cell Biol. 1990 Sep;111(3):839-55 - PubMed
  88. J Immunol. 2003 Feb 1;170(3):1473-80 - PubMed
  89. J Immunol. 2007 Nov 1;179(9):5907-15 - PubMed
  90. J Immunol. 1982 Dec;129(6):2564-9 - PubMed
  91. Int Immunol. 2013 Apr;25(4):235-46 - PubMed
  92. EMBO J. 1986 Dec 20;5(13):3483-8 - PubMed
  93. J Leukoc Biol. 2009 Feb;85(2):215-24 - PubMed
  94. Blood. 1993 Oct 15;82(8):2494-500 - PubMed
  95. J Exp Med. 2013 Jan 14;210(1):23-30 - PubMed
  96. Int Immunol. 1994 Mar;6(3):439-51 - PubMed
  97. Immunol Rev. 2005 Oct;207:229-41 - PubMed
  98. Immunity. 1995 Mar;2(3):301-10 - PubMed
  99. EMBO J. 1996 Jan 15;15(2):418-28 - PubMed
  100. Scand J Immunol. 2009 Sep;70(3):184-93 - PubMed
  101. Curr Opin Immunol. 1995 Feb;7(1):77-84 - PubMed
  102. J Exp Med. 1986 Nov 1;164(5):1490-504 - PubMed
  103. J Immunol. 1999 Nov 15;163(10):5435-43 - PubMed
  104. Mol Biol Cell. 2002 Jun;13(6):1846-56 - PubMed
  105. J Cell Sci. 1993 Nov;106 ( Pt 3):831-46 - PubMed
  106. Cell. 1993 Jul 30;74(2):257-68 - PubMed
  107. J Immunol. 2003 May 1;170(9):4683-92 - PubMed
  108. J Cell Biol. 1999 Nov 15;147(4):775-90 - PubMed
  109. Cell. 1993 Feb 26;72(4):635-48 - PubMed
  110. Immunol Rev. 2005 Oct;207:242-60 - PubMed
  111. J Immunol. 1998 Apr 1;160(7):3101-10 - PubMed
  112. J Exp Med. 1993 Mar 1;177(3):583-96 - PubMed
  113. J Biol Chem. 1995 Feb 10;270(6):2741-6 - PubMed
  114. Cell. 2002 Nov 15;111(4):577-88 - PubMed
  115. J Biochem. 2004 Dec;136(6):755-60 - PubMed
  116. Biochim Biophys Acta. 2002 Jan 30;1542(1-3):1-13 - PubMed
  117. Proc Natl Acad Sci U S A. 1997 May 27;94(11):5772-7 - PubMed

Publication Types