Display options
Cite
Velam V, Yalavarthi PR, Sundaresan C, et al. In vitro and in vivo assessment of piroxicam incorporated Aloe vera transgel. Int J Pharm Investig. 2013;3(4):212-6doi: 10.4103/2230-973X.121303.
Velam, V., Yalavarthi, P. R., Sundaresan, C., Vandana, K., Dudala, T. B., Kodavatikanti, H., & Vadlamudi, H. C. (2013). In vitro and in vivo assessment of piroxicam incorporated Aloe vera transgel. International journal of pharmaceutical investigation, 3(4), 212-6. https://doi.org/10.4103/2230-973X.121303
Velam, Vinesha, et al. "In vitro and in vivo assessment of piroxicam incorporated Aloe vera transgel." International journal of pharmaceutical investigation vol. 3,4 (2013): 212-6. doi: https://doi.org/10.4103/2230-973X.121303
Velam V, Yalavarthi PR, Sundaresan C, Vandana K, Dudala TB, Kodavatikanti H, Vadlamudi HC. In vitro and in vivo assessment of piroxicam incorporated Aloe vera transgel. Int J Pharm Investig. 2013 Oct;3(4):212-6. doi: 10.4103/2230-973X.121303. PMID: 24350041; PMCID: PMC3853761.
Copy Download .nbib Format: NLM
Share it on

Int J Pharm Investig. 2013 Oct;3(4):212-6. doi: 10.4103/2230-973X.121303.

In vitro and in vivo assessment of piroxicam incorporated Aloe vera transgel.

International journal of pharmaceutical investigation

Vinesha Velam, Prasanna Raju Yalavarthi, Cr Sundaresan, Kr Vandana, Thushara Bindu Dudala, Haritha Kodavatikanti, Harini Chowdary Vadlamudi

Affiliations

  1. Department of Pharmaceutics, Sree Vidyankethan College of Pharmacy, A. Rangampet, Tirupati, Andhra Pradesh, India.
  2. Department of Medicine, Faculty of Medicine, University College Sedaya International University, Kuala Lumpur, Malaysia.

PMID: 24350041 PMCID: PMC3853761 DOI: 10.4103/2230-973X.121303

Abstract

BACKGROUND: The aim of the study was to develop piroxicam-Aloe vera gel (PAG) formulation and make a pharmacodynamic evaluation of the formulation.

MATERIALS AND METHODS: The gel was prepared by using carbopol 934 as gelling agent and methyl paraben as a preservative in an Aloe vera gel base. The formulated gel was also evaluated for physicochemical parameters like pH, viscosity, drug content, and in vitro diffusion assessment. Pharmacodynamic activity of the formulation was evaluated in Wistar albino rats. The formulated gel was compared with that of similar marketed gel (commercial piroxicam gel (CPG)) against the same parameters.

RESULTS: From in vitro studies, an effective drug release from PAG was observed to be 68.17% when compared with that of the CPG (62.71%) at 180 min indicating better drug release from the gel formulated in this study. Percentage inhibition of edema was greater for the preparation of PAG (29.57 mean percent inhibition after 60 min) compared to marketed gel which exhibited 18.3% after 60 min.

CONCLUSION: It was concluded from the results that the Aloe vera gel acts as an effective gel base to prepare piroxicam gel with high drug loading capacity and improved anti-inflammatory effect. From the statistical analysis the formulation of PAG showed better release than the CPG at p < 0.05 level of significance.

Keywords: % inhibition; Aloe vera; carbopol 934; edema; flux; in vitro diffusion; pharmacodynamic activity; piroxicam

References

  1. Int J Pharm. 2005 Jul 14;298(1):47-54 - PubMed
  2. J Ethnopharmacol. 1986 Jun;16(2-3):117-51 - PubMed
  3. J Am Pharm Assoc Am Pharm Assoc. 1956 Apr;45(4):212-8 - PubMed
  4. J Ethnopharmacol. 2008 Nov 20;120(2):181-9 - PubMed
  5. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2006 Apr;24(1):103-54 - PubMed
  6. J Pharm Biomed Anal. 2001 Nov;26(4):531-7 - PubMed
  7. Res Pharm Sci. 2012 Oct;7(4):225-34 - PubMed
  8. Int J Pharm. 2000 Jan 5;193(2):261-4 - PubMed
  9. Eur J Pharm Sci. 2001 Sep;14(2):101-14 - PubMed
  10. Br J Pharmacol. 1971 Jul;42(3):392-402 - PubMed
  11. Int J Pharm. 2000 Jan 5;193(2):213-8 - PubMed
  12. Int J Biol Macromol. 2013 Apr;55:246-53 - PubMed

Publication Types