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Campese V, McCue M, Lázaro-Muñoz G, et al. Development of an aversive Pavlovian-to-instrumental transfer task in rat. Front Behav Neurosci. 2013;7:176doi: 10.3389/fnbeh.2013.00176.
Campese, V., McCue, M., Lázaro-Muñoz, G., Ledoux, J. E., & Cain, C. K. (2013). Development of an aversive Pavlovian-to-instrumental transfer task in rat. Frontiers in behavioral neuroscience, 7176. https://doi.org/10.3389/fnbeh.2013.00176
Campese, Vincent, et al. "Development of an aversive Pavlovian-to-instrumental transfer task in rat." Frontiers in behavioral neuroscience vol. 7 (2013): 176. doi: https://doi.org/10.3389/fnbeh.2013.00176
Campese V, McCue M, Lázaro-Muñoz G, Ledoux JE, Cain CK. Development of an aversive Pavlovian-to-instrumental transfer task in rat. Front Behav Neurosci. 2013 Nov 26;7:176. doi: 10.3389/fnbeh.2013.00176. eCollection 2013. PMID: 24324417; PMCID: PMC3840425.
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Front Behav Neurosci. 2013 Nov 26;7:176. doi: 10.3389/fnbeh.2013.00176. eCollection 2013.

Development of an aversive Pavlovian-to-instrumental transfer task in rat.

Frontiers in behavioral neuroscience

Vincent Campese, Margaret McCue, Gabriel Lázaro-Muñoz, Joseph E Ledoux, Christopher K Cain

Affiliations

  1. Center for Neural Science, New York University New York, NY, USA.

PMID: 24324417 PMCID: PMC3840425 DOI: 10.3389/fnbeh.2013.00176

Abstract

Pavlovian-to-instrumental transfer (PIT) is an effect whereby a classically conditioned stimulus (CS) enhances ongoing instrumental responding. PIT has been extensively studied with appetitive conditioning but barely at all with aversive conditioning. Although it's been argued that conditioned suppression is a form of aversive PIT, this effect is fundamentally different from appetitive PIT because the CS suppresses, instead of facilitates, responding. Five experiments investigated the importance of a variety of factors on aversive PIT in a rodent Sidman avoidance paradigm in which ongoing shuttling behavior (unsignaled active avoidance or USAA) was facilitated by an aversive CS. Experiment 1 demonstrated a basic PIT effect. Experiment 2 found that a moderate amount of USAA extinction produces the strongest PIT with shuttling rates best at around 2 responses per minute prior to the CS. Experiment 3 tested a protocol in which the USAA behavior was required to reach the 2-response per minute mark in order to trigger the CS presentation and found that this produced robust and reliable PIT. Experiment 4 found that the Pavlovian conditioning US intensity was not a major determinant of PIT strength. Experiment 5 demonstrated that if the CS and US were not explicitly paired during Pavlovian conditioning, PIT did not occur, showing that CS-US learning is required. Together, these studies demonstrate a robust, reliable and stable aversive PIT effect that is amenable to analysis of neural circuitry.

Keywords: Pavlovian; avoidance; instrumental; rat; shuttling; transfer

References

  1. Trends Neurosci. 2006 May;29(5):272-9 - PubMed
  2. J Comp Physiol Psychol. 1968 Feb;65(1):55-60 - PubMed
  3. Behav Neurosci. 2000 Jun;114(3):468-83 - PubMed
  4. J Exp Psychol Anim Behav Process. 1983 Jul;9(3):225-47 - PubMed
  5. Ann N Y Acad Sci. 2003 Apr;985:206-17 - PubMed
  6. PLoS One. 2012;7(10):e48227 - PubMed
  7. Eur J Neurosci. 2001 May;13(10):1984-92 - PubMed
  8. J Comp Physiol Psychol. 1967 Aug;64(1):154-8 - PubMed
  9. J Neurosci. 2011 Aug 17;31(33):11786-94 - PubMed
  10. J Comp Physiol Psychol. 1953 Aug;46(4):253-61 - PubMed
  11. Nature. 1997 Jul 24;388(6640):377-80 - PubMed
  12. Science. 1953 Aug 7;118(3058):157-8 - PubMed
  13. Emotion. 2011 Oct;11(5):1112-23 - PubMed
  14. Biol Psychiatry. 2010 Jun 15;67(12):1120-7 - PubMed
  15. Neurosci Biobehav Rev. 2010 Jul;34(8):1277-95 - PubMed
  16. Acta Neurobiol Exp (Wars). 1971;31(4):341-9 - PubMed
  17. Neuron. 2005 Sep 15;47(6):783-6 - PubMed
  18. Biol Psychiatry. 2012 Jun 15;71(12):1053-60 - PubMed
  19. Behav Res Ther. 1977;15(1):51-6 - PubMed
  20. Cell. 2011 Oct 28;147(3):509-24 - PubMed
  21. J Exp Anal Behav. 1964 Jul;7:315-21 - PubMed
  22. Neurosci Biobehav Rev. 2002 May;26(3):321-52 - PubMed
  23. Behav Neurosci. 1985 Apr;99(2):342-80 - PubMed
  24. Eur J Neurosci. 2010 Nov;32(10):1735-43 - PubMed
  25. J Exp Psychol Anim Behav Process. 1994 Jan;20(1):44-50 - PubMed
  26. Eur J Neurosci. 2003 Apr;17(8):1680-94 - PubMed
  27. Learn Mem. 2010 Feb 26;17(3):139-47 - PubMed
  28. J Exp Psychol. 1948 Apr;38(2):173-7 - PubMed
  29. J Neurosci. 2005 Jan 26;25(4):962-70 - PubMed
  30. J Comp Physiol Psychol. 1965 Jun;59:406-12 - PubMed
  31. J Comp Physiol Psychol. 1951 Feb;44(1):88-98 - PubMed

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