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Pace V, Rae JP, Procter DJ. Cu(I)-NHC catalyzed asymmetric silyl transfer to unsaturated lactams and amides. Org Lett. 2013;16(2):476-9doi: 10.1021/ol4033623.
Pace, V., Rae, J. P., & Procter, D. J. (2014). Cu(I)-NHC catalyzed asymmetric silyl transfer to unsaturated lactams and amides. Organic letters, 16(2), 476-9. https://doi.org/10.1021/ol4033623
Pace, Vittorio, et al. "Cu(I)-NHC catalyzed asymmetric silyl transfer to unsaturated lactams and amides." Organic letters vol. 16,2 (2014): 476-9. doi: https://doi.org/10.1021/ol4033623
Pace V, Rae JP, Procter DJ. Cu(I)-NHC catalyzed asymmetric silyl transfer to unsaturated lactams and amides. Org Lett. 2014 Jan 17;16(2):476-9. doi: 10.1021/ol4033623. Epub 2013 Dec 18. PMID: 24350760.
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Org Lett. 2014 Jan 17;16(2):476-9. doi: 10.1021/ol4033623. Epub 2013 Dec 18.

Cu(I)-NHC catalyzed asymmetric silyl transfer to unsaturated lactams and amides.

Organic letters

Vittorio Pace, James P Rae, David J Procter

Affiliations

  1. School of Chemistry, University of Manchester , Oxford Road, Manchester, M13 9PL, U.K.

PMID: 24350760 DOI: 10.1021/ol4033623

Abstract

The first asymmetric silylation of unsaturated lactams and amides using Cu(I)-NHC catalysts and PhMe2SiBpin has been accomplished. The method has been exploited in an expedient asymmetric synthesis of the (R)-enantiomer of the nootropic drug oxiracetam.

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