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Nerfeldt P, Nilsson BY, Mayor L, et al. Weight reduction improves sleep, sleepiness and metabolic status in obese sleep apnoea patients. Obes Res Clin Pract. 2008;2(4):I-IIdoi: 10.1016/j.orcp.2008.08.001.
Nerfeldt, P., Nilsson, B. Y., Mayor, L., Uddén, J., Rössner, S., & Friberg, D. (2008). Weight reduction improves sleep, sleepiness and metabolic status in obese sleep apnoea patients. Obesity research & clinical practice, 2(4), I-II. https://doi.org/10.1016/j.orcp.2008.08.001
Nerfeldt, Pia, et al. "Weight reduction improves sleep, sleepiness and metabolic status in obese sleep apnoea patients." Obesity research & clinical practice vol. 2,4 (2008): I-II. doi: https://doi.org/10.1016/j.orcp.2008.08.001
Nerfeldt P, Nilsson BY, Mayor L, Uddén J, Rössner S, Friberg D. Weight reduction improves sleep, sleepiness and metabolic status in obese sleep apnoea patients. Obes Res Clin Pract. 2008 Dec;2(4):I-II. doi: 10.1016/j.orcp.2008.08.001. PMID: 24351852.
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Obes Res Clin Pract. 2008 Dec;2(4):I-II. doi: 10.1016/j.orcp.2008.08.001.

Weight reduction improves sleep, sleepiness and metabolic status in obese sleep apnoea patients.

Obesity research & clinical practice

Pia Nerfeldt, Bengt Y Nilsson, Liliana Mayor, Joanna Uddén, Stephan Rössner, Danielle Friberg

Affiliations

  1. Department of Clinical Science, Intervention and Technology, Division of Ear, Nose and Throat Diseases, Karolinska Institute, Karolinska University Hospital-Huddinge, SE-141 86, Stockholm, Sweden. Electronic address:[email protected].
  2. Department of Clinical Science, Intervention and Technology, Division of Ear, Nose and Throat Diseases, Karolinska Institute, Karolinska University Hospital-Huddinge, SE-141 86, Stockholm, Sweden.

PMID: 24351852 DOI: 10.1016/j.orcp.2008.08.001

Abstract

METHOD: In this prospective intervention study, 33 obese patients with obstructive sleep apnoea syndrome (OSAS) (24 men, 9 women) were consecutively enrolled for a weight reduction program at the Obesity Unit, Karolinska University Hospital. 23 of 33 patients used OSAS-device, 19 with Continuous Positive Airway Pressure and 4 with Mandibular Retaining Device. The patients were investigated with questionnaires, blood tests and ambulant nocturnal polysomnography before and after a 6-month program. Patients with OSAS-device slept without it during the sleep studies. The intervention consisted of 8 weeks low calorie diet and group meetings, followed by a day-care program of behaviour change support.

RESULTS: 27 of 33 patients (82%, 21 men and 6 women) completed the study. After the intervention there were highly significant decreases (p < 0.001) in Body Mass Index from mean(S.D.) 40(5) to 34(3), apnoea-hypopnoea index from 43(24) to 26(20) and Epworth Sleepiness Scale (ESS)-score from 9(4) to 6(4). Sleep quality (arousal index, sleep efficiency, percentage deep sleep) and metabolic status (blood pressure, blood glucose levels, lipidemia) were also significantly improved. There was a significant correlation between increased percentage deep sleep and reduced ESS-score. There were no differences due to gender or use/no use of OSAS-device.

CONCLUSION: The results suggest that weight loss, induced by low calorie diet and behaviour change support, significantly improves nocturnal respiratory parameters, sleep quality, daytime sleepiness and metabolic status in obese OSAS patients after 6 months.

© 2008 Asian Oceanian Association for the Study of Obesity . Published by Elsevier Ltd. All rights reserved.

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