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Shao J, Feng G. Selective killing effect of oxytetracycline, propafenone and metamizole on A549 or Hela cells. Chin J Cancer Res. 2013;25(6):662-70doi: 10.3978/j.issn.1000-9604.2013.11.05.
Shao, J., & Feng, G. (2013). Selective killing effect of oxytetracycline, propafenone and metamizole on A549 or Hela cells. Chinese journal of cancer research = Chung-kuo yen cheng yen chiu, 25(6), 662-70. https://doi.org/10.3978/j.issn.1000-9604.2013.11.05
Shao, Jinhui, and Feng, Guihua. "Selective killing effect of oxytetracycline, propafenone and metamizole on A549 or Hela cells." Chinese journal of cancer research = Chung-kuo yen cheng yen chiu vol. 25,6 (2013): 662-70. doi: https://doi.org/10.3978/j.issn.1000-9604.2013.11.05
Shao J, Feng G. Selective killing effect of oxytetracycline, propafenone and metamizole on A549 or Hela cells. Chin J Cancer Res. 2013 Dec;25(6):662-70. doi: 10.3978/j.issn.1000-9604.2013.11.05. PMID: 24385693; PMCID: PMC3872553.
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Chin J Cancer Res. 2013 Dec;25(6):662-70. doi: 10.3978/j.issn.1000-9604.2013.11.05.

Selective killing effect of oxytetracycline, propafenone and metamizole on A549 or Hela cells.

Chinese journal of cancer research = Chung-kuo yen cheng yen chiu

Jinhui Shao, Guihua Feng

Affiliations

  1. Department of Histology and Embryology, School of Medicine, Hubei University of Art and Science, Xiangyang 441053, China.

PMID: 24385693 PMCID: PMC3872553 DOI: 10.3978/j.issn.1000-9604.2013.11.05

Abstract

OBJECTIVE: To determine the selective killing effect of oxytetracycline, propafenone and metamizole on A549 or Hela cells.

METHODS: Proliferation assay, lactate dehydrogenase (LDH) assay, apoptosis detecting, flow cytometry and western blot were performed.

RESULTS: It was found that treatment with propafenone at the concentration of 0.014 g/L or higher for 48 h could induce apoptosis in Hela cells greatly, while it was not observed in oxytetracycline and metamizole at the concentration of 0.20 g/L for 48 h. Oxytetracycline, propafenone and metamizole all displayed evident inhibitory effects on the proliferation of A549 cells. The results of LDH assay demonstrated that the drugs at the test range of concentration did not cause necrosis in the cells. Propafenone could elevate the protein level of P53 effectively (P<0.01).

CONCLUSIONS: Oxytetracycline, propafenone and metamizol (dipyrone) all displayed evident inhibitory effects on the proliferation of A549 cells. Propafenone also displayed evident inhibitory effects on the proliferation of Hela cells.

Keywords: Cancer; drug; metamizol; oxytetracycline; propafenone

References

  1. Cancer Res. 1977 Sep;37(9):3209-13 - PubMed
  2. Cell Stem Cell. 2011 Dec 2;9(6):575-87 - PubMed
  3. PLoS One. 2011;6(8):e23427 - PubMed
  4. Mol Cancer. 2010 Jan 28;9:20 - PubMed
  5. Eur J Med Chem. 2013 May;63:256-68 - PubMed
  6. Int J Biol Sci. 2012;8(5):672-84 - PubMed
  7. Asian Pac J Cancer Prev. 2013;14(5):3041-4 - PubMed
  8. Best Pract Res Clin Anaesthesiol. 2007 Mar;21(1):15-30 - PubMed
  9. J Natl Cancer Inst. 1990 Jul 4;82(13):1113-8 - PubMed
  10. Nutrients. 2013 Sep 09;5(9):3496-505 - PubMed
  11. Oncol Rep. 2013 Apr;29(4):1671-7 - PubMed
  12. Ther Adv Musculoskelet Dis. 2011 Aug;3(4):201-5 - PubMed
  13. Cancer Res. 1981 May;41(5):1943-7 - PubMed
  14. Biol Pharm Bull. 2007 Dec;30(12):2394-8 - PubMed
  15. Cell Stem Cell. 2010 Jan 8;6(1):71-9 - PubMed
  16. Anal Biochem. 1976 May 7;72:248-54 - PubMed
  17. Anticancer Drugs. 2012 Apr;23(4):437-44 - PubMed
  18. Bioorg Med Chem. 2009 Oct 15;17(20):7085-92 - PubMed
  19. Can J Cardiol. 2010 Jun-Jul;26(6):209-10 - PubMed
  20. Br J Pharmacol. 2009 Aug;157(7):1097-110 - PubMed
  21. Bioorg Med Chem Lett. 2011 Jul 1;21(13):3909-13 - PubMed
  22. Cancer Res. 2005 Mar 1;65(5):1687-92 - PubMed
  23. Proc Natl Acad Sci U S A. 1996 Sep 17;93(19):10393-8 - PubMed
  24. J Antimicrob Chemother. 1992 Mar;29(3):245-77 - PubMed
  25. Metabolism. 2010 Feb;59(2):285-92 - PubMed
  26. Eur J Med Chem. 2011 Jun;46(6):2359-67 - PubMed
  27. Nat Rev Drug Discov. 2004 May;3(5):417-29 - PubMed
  28. Autophagy. 2008 Feb;4(2):151-75 - PubMed
  29. Int J Oncol. 2013 Oct;43(4):1269-80 - PubMed
  30. CA Cancer J Clin. 2008 Mar-Apr;58(2):71-96 - PubMed
  31. Cell Mol Life Sci. 2008 Feb;65(3):354-8 - PubMed
  32. J Natl Cancer Inst. 1990 Jul 4;82(13):1107-12 - PubMed
  33. Mol Cancer Ther. 2008 Jun;7(6):1588-97 - PubMed
  34. Biochem J. 1998 Sep 1;334 ( Pt 2):457-61 - PubMed
  35. Lab Anim. 2011 Jan;45(1):38-44 - PubMed
  36. J Am Coll Cardiol. 2004 Feb 18;43(4):519-25 - PubMed

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