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Fasunla AJ, Harbeck N, Schmalfeld B, et al. Is routine audiometric evaluation necessary in gynaecologic tumour patients undergoing chemotherapy?. Breast Care (Basel). 2013;8(4):276-81doi: 10.1159/000354125.
Fasunla, A. J., Harbeck, N., Schmalfeld, B., Berktold, S., Böhner, C., Hundt, W., Wolf, P., & Steinbach, S. (2013). Is routine audiometric evaluation necessary in gynaecologic tumour patients undergoing chemotherapy?. Breast care (Basel, Switzerland), 8(4), 276-81. https://doi.org/10.1159/000354125
Fasunla, Ayotunde J, et al. "Is routine audiometric evaluation necessary in gynaecologic tumour patients undergoing chemotherapy?." Breast care (Basel, Switzerland) vol. 8,4 (2013): 276-81. doi: https://doi.org/10.1159/000354125
Fasunla AJ, Harbeck N, Schmalfeld B, Berktold S, Böhner C, Hundt W, Wolf P, Steinbach S. Is routine audiometric evaluation necessary in gynaecologic tumour patients undergoing chemotherapy?. Breast Care (Basel). 2013 Aug;8(4):276-81. doi: 10.1159/000354125. PMID: 24415980; PMCID: PMC3808219.
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Breast Care (Basel). 2013 Aug;8(4):276-81. doi: 10.1159/000354125.

Is routine audiometric evaluation necessary in gynaecologic tumour patients undergoing chemotherapy?.

Breast care (Basel, Switzerland)

Ayotunde J Fasunla, Nadia Harbeck, Barbara Schmalfeld, Sabina Berktold, Christina Böhner, Walter Hundt, Petra Wolf, Silke Steinbach

Affiliations

  1. Department of Otorhinolaryngology, Philipps-University, Marburg, Germany ; Department of Otorhinolaryngology, College of Medicine, University of Ibadan and University College Hospital, Ibadan, Nigeria, Germany.
  2. Breast Centre, Ludwig-Maximilians University, Munich, Germany.
  3. Department of Obstetrics and Gynaecology, Women's Hospital Rechts der Isar, Germany.
  4. Department of Radiology, Philipps-University, Marburg, Germany.
  5. Institute of Medical Statistics and Epidemiology, Hospital Rechts der Isar, Technical University Munich, Germany.
  6. Department of Otorhinolaryngology, Philipps-University, Marburg, Germany.

PMID: 24415980 PMCID: PMC3808219 DOI: 10.1159/000354125

Abstract

BACKGROUND: Our objective was to assess the auditory function of gynaecological tumour patients who had received cytotoxic agents and to determine their associated risk of ototoxicity.

PATIENTS AND METHODS: 87 patients who had undergone chemotherapy for gynaecological malignancies were investigated. Of these patients, 79% had breast cancer, and 14% ovarian cancer. All of the patients had a subjective assessment of their hearing function on a visual analogue scale. Audiometric tests were performed before and at 9 weeks, 18 weeks and 3 months after completion of chemotherapy.

RESULTS: The age of the patients ranged from 32 to 71 years (mean age of 53.5 ± 10.5 years). The average subjective rating of the patients' hearing function was 83.0 ± 17.2 before and 84.8 ± 16.9 3 months after completion of chemotherapy. No significant audiometric change at either the speech hearing frequency range (0.5-2 KHz) or high frequencies was observed in the patients after chemotherapy. There was also no significant difference in the hearing threshold of the patients who had received platinum analogue-based chemotherapy compared to non-platinum analogue-based chemotherapy.

CONCLUSION: Hearing loss is uncommon in patients treated with the typical gynaecological chemotherapy protocols. Hence, routine audiometric testing in these patients is not necessary.

Keywords: Breast cancer; Chemotherapy; Hearing function; Ovarian cancer

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