Display options
Cite
Grenier G, Leblanc E, Faucheux N, et al. BMP-9 expression in human traumatic heterotopic ossification: a case report. Skelet Muscle. 2013;3(1):29doi: 10.1186/2044-5040-3-29.
Grenier, G., Leblanc, E., Faucheux, N., Lauzier, D., Kloen, P., & Hamdy, R. C. (2013). BMP-9 expression in human traumatic heterotopic ossification: a case report. Skeletal muscle, 3(1), 29. https://doi.org/10.1186/2044-5040-3-29
Grenier, Guillaume, et al. "BMP-9 expression in human traumatic heterotopic ossification: a case report." Skeletal muscle vol. 3,1 (2013): 29. doi: https://doi.org/10.1186/2044-5040-3-29
Grenier G, Leblanc E, Faucheux N, Lauzier D, Kloen P, Hamdy RC. BMP-9 expression in human traumatic heterotopic ossification: a case report. Skelet Muscle. 2013 Dec 16;3(1):29. doi: 10.1186/2044-5040-3-29. PMID: 24330639; PMCID: PMC3878643.
Copy Download .nbib Format: NLM
Share it on

Skelet Muscle. 2013 Dec 16;3(1):29. doi: 10.1186/2044-5040-3-29.

BMP-9 expression in human traumatic heterotopic ossification: a case report.

Skeletal muscle

Guillaume Grenier, Elisabeth Leblanc, Nathalie Faucheux, Dominique Lauzier, Peter Kloen, Reggie C Hamdy

Affiliations

  1. Shriners Hospital for Children, 1529 Cedar Avenue, Montreal, QC H3G 1A6, Canada. [email protected].

PMID: 24330639 PMCID: PMC3878643 DOI: 10.1186/2044-5040-3-29

Abstract

BACKGROUND: Heterotopic ossification (HO) is defined as the abnormal formation of mature bone in soft tissue, notably skeletal muscle. The morbidity of HO in polytraumatized patients impacts the functional outcome, impairs rehabilitation, and increases costs due to subsequent surgical interventions.

CASE PRESENTATION: We present the case of a 34-year-old African male who developed severe HO around his right hip 11 days after a major trauma. Immunohistochemical analyses of resected tissue revealed that several BMPs were expressed in the HO, including highly osteogenic BMP-9.

CONCLUSIONS: To the best of our knowledge, this is the first report of local BMP expression, notably BMP-9, in traumatic HO, and suggests that BMP-9, possibly through mrSCs, can contribute to HO formation in soft tissues when a suitable microenvironment is present.

References

  1. Int Orthop. 2009 Feb;33(1):281-8 - PubMed
  2. Plast Reconstr Surg. 2003 Jan;111(1):201-8; discussion 209-10 - PubMed
  3. Clin Orthop Relat Res. 2005 Sep;438:221-32 - PubMed
  4. J Orthop Trauma. 2006 Jan;20(1 Suppl):S52-6 - PubMed
  5. Int J Biol Sci. 2012;8(2):272-88 - PubMed
  6. Circ Res. 2008 Apr 25;102(8):914-22 - PubMed
  7. J Bone Miner Res. 2011 Jun;26(6):1166-77 - PubMed
  8. Cell Mol Life Sci. 2012 Jan;69(2):313-24 - PubMed
  9. Bone. 2000 Sep;27(3):453-9 - PubMed
  10. Expert Opin Ther Targets. 2009 Jan;13(1):123-37 - PubMed
  11. Cell Signal. 2011 Apr;23(4):609-20 - PubMed
  12. J Am Acad Orthop Surg. 2008 Feb;16(2):68-76 - PubMed
  13. J Bone Miner Res. 2011 Jun;26(6):1163-5 - PubMed
  14. Bone. 2012 Jul;51(1):59-68 - PubMed
  15. Clin Orthop Relat Res. 2009 Dec;467(12):3071-8 - PubMed
  16. Trends Biochem Sci. 2000 Feb;25(2):64-70 - PubMed
  17. J Musculoskelet Neuronal Interact. 2010 Mar;10(1):71-6 - PubMed
  18. J Biochem. 2012 Mar;151(3):247-54 - PubMed
  19. J Orthop Res. 2013 Nov;31(11):1796-803 - PubMed
  20. Hip Int. 2010;20 Suppl 7:S2-10 - PubMed
  21. Bone. 2003 Aug;33(2):248-55 - PubMed
  22. J Histochem Cytochem. 2006 Apr;54(4):407-15 - PubMed
  23. Bone. 2013 Sep;56(1):119-26 - PubMed
  24. J Bone Joint Surg Br. 1975 Feb;57(1):36-45 - PubMed
  25. J Orthop Surg Res. 2009 Apr 20;4:12 - PubMed
  26. Tissue Eng Part A. 2009 Nov;15(11):3341-9 - PubMed
  27. Gene Ther. 2004 Sep;11(17):1312-20 - PubMed
  28. Bone. 2008 Jun;42(6):1144-53 - PubMed
  29. J Bone Joint Surg Am. 2002 Nov;84(11):1909-18 - PubMed
  30. J Orthop Trauma. 2012 Dec;26(12):684-8 - PubMed
  31. Bone. 2003 Sep;33(3):362-71 - PubMed
  32. Clin Orthop Relat Res. 1992 Dec;(285):236-43 - PubMed
  33. Gene Ther. 2003 Sep;10(20):1735-43 - PubMed
  34. J Bone Joint Surg Am. 2011 Jun 15;93(12):1122-31 - PubMed
  35. Differentiation. 2009 Jan;77(1):12-8 - PubMed
  36. J Bone Miner Res. 2012 May;27(5):1004-17 - PubMed

Publication Types