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McIntosh MS, Kumar V, Kalynych C, et al. Racial Differences in Blood Lipids Lead to Underestimation of Cardiovascular Risk in Black Women in a Nested observational Study. Glob Adv Health Med. 2013;2(2):76-9doi: 10.7453/gahmj.2012.076.
McIntosh, M. S., Kumar, V., Kalynych, C., Lott, M., Hsi, A., Chang, J. L., & Lerman, R. H. (2013). Racial Differences in Blood Lipids Lead to Underestimation of Cardiovascular Risk in Black Women in a Nested observational Study. Global advances in health and medicine, 2(2), 76-9. https://doi.org/10.7453/gahmj.2012.076
McIntosh, Mark S, et al. "Racial Differences in Blood Lipids Lead to Underestimation of Cardiovascular Risk in Black Women in a Nested observational Study." Global advances in health and medicine vol. 2,2 (2013): 76-9. doi: https://doi.org/10.7453/gahmj.2012.076
McIntosh MS, Kumar V, Kalynych C, Lott M, Hsi A, Chang JL, Lerman RH. Racial Differences in Blood Lipids Lead to Underestimation of Cardiovascular Risk in Black Women in a Nested observational Study. Glob Adv Health Med. 2013 Mar;2(2):76-9. doi: 10.7453/gahmj.2012.076. PMID: 24416666; PMCID: PMC3833531.
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Glob Adv Health Med. 2013 Mar;2(2):76-9. doi: 10.7453/gahmj.2012.076.

Racial Differences in Blood Lipids Lead to Underestimation of Cardiovascular Risk in Black Women in a Nested observational Study.

Global advances in health and medicine

Mark S McIntosh, Vivek Kumar, Colleen Kalynych, Michelle Lott, Alex Hsi, Jyh-Lurn Chang, Robert H Lerman

Affiliations

  1. Department of Emergency Medicine, University of Florida, Jacksonville, United States.
  2. Department of Emergency Medicine, University of Florida, Jacksonville.
  3. Metagenics, Inc, Gig Harbor, Washington, United States.

PMID: 24416666 PMCID: PMC3833531 DOI: 10.7453/gahmj.2012.076

Abstract

BACKGROUND: During screening for enrollment in a clinical trial, we noticed potential racial disparities in metabolic syndrome variables in women who responded to our study advertisement. We designed a nested observational study to investigate whether metabolic syndrome variables differed between non-Hispanic blacks and non-Hispanic whites.

METHODS: The cohort comprised of women who have met the preliminary clinical trial criteria (body mass index [BMI] 25-45, age 20-75 years, and no use of lipid-lowering medications or supplements). These women, including 116 blacks and 138 whites, provided fasting blood samples for analysis of serum lipid profile.

RESULTS: Blacks had lower mean triglycerides (81.1 ± 3.3 mg/dL vs 140.6 ± 5.9 mg/dL; P < .0001), total cholesterol (176.1 ± 3.6 mg/dL vs 201.6 ± 3.3 mg/dL; P < .0001), and low-density lipoprotein (111.7 ± 3.3 mg/dL vs 128.2 ± 2.9 mg/dL; P < .001) and higher mean BMI (37.2 ± 0.5 vs 35.2 ± 0.5; P < .01) and diastolic blood pressure (82.4 ± 0.8 mmHg vs 79.4 ± 0.7 mmHg; P < .01) than whites. Only 7% of blacks, compared with 41% of whites, had triglycerides ≥150 mg/dL; as a result, fewer black women met metabolic syndrome criteria than white women. Additionally, in women with waist circumference ≥88 cm (N = 215), high-density lipoprotein was higher in blacks than in whites (48.3 ± 1.5 mg/dL vs 44.2 ±1.3 mg/dL; P < .05).

CONCLUSIONS: Due to racial differences in blood lipids, current metabolic syndrome criteria may result in underestimation of cardiovascular risk in blacks.

Keywords: Women; cardiovascular disease; cholesterol; metabolic syndrome; race; triglycerides

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