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Flor-Parra I, Bernal M, Zhurinsky J, et al. Cell migration and division in amoeboid-like fission yeast. Biol Open. 2014;3(1):108-15doi: 10.1242/bio.20136783.
Flor-Parra, I., Bernal, M., Zhurinsky, J., & Daga, R. R. (2014). Cell migration and division in amoeboid-like fission yeast. Biology open, 3(1), 108-15. https://doi.org/10.1242/bio.20136783
Flor-Parra, Ignacio, et al. "Cell migration and division in amoeboid-like fission yeast." Biology open vol. 3,1 (2014): 108-15. doi: https://doi.org/10.1242/bio.20136783
Flor-Parra I, Bernal M, Zhurinsky J, Daga RR. Cell migration and division in amoeboid-like fission yeast. Biol Open. 2014 Jan 15;3(1):108-15. doi: 10.1242/bio.20136783. PMID: 24357230; PMCID: PMC3892166.
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Biol Open. 2014 Jan 15;3(1):108-15. doi: 10.1242/bio.20136783.

Cell migration and division in amoeboid-like fission yeast.

Biology open

Ignacio Flor-Parra, Manuel Bernal, Jacob Zhurinsky, Rafael R Daga

Affiliations

  1. Centro Andaluz de Biología del Desarrollo, Universidad Pablo de Olavide-Consejo Superior de Investigaciones Científicas, 41013 Sevilla, Spain.

PMID: 24357230 PMCID: PMC3892166 DOI: 10.1242/bio.20136783

Abstract

Yeast cells are non-motile and are encased in a cell wall that supports high internal turgor pressure. The cell wall is also essential for cellular morphogenesis and cell division. Here, we report unexpected morphogenetic changes in a Schizosaccharomyces pombe mutant defective in cell wall biogenesis. These cells form dynamic cytoplasmic protrusions caused by internal turgor pressure and also exhibit amoeboid-like cell migration resulting from repeated protrusive cycles. The cytokinetic ring responsible for cell division in wild-type yeast often fails in these cells; however, they were still able to divide using a ring-independent alternative mechanism relying on extrusion of the cell body through a hole in the cell wall. This mechanism of cell division may resemble an ancestral mode of division in the absence of cytokinetic machinery. Our findings highlight how a single gene change can lead to the emergence of different modes of cell growth, migration and division.

Keywords: Cell migration; Cytokinesis; Fission yeast; Morphogenesis; Turgor pressure

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