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Mod Rheumatol. 2003 Mar;13(1):90-4. doi: 10.3109/s101650300015.

Behçet's disease accompanied by myelodysplastic syndrome with trisomy 8: two case reports and a review of 15 Japanese cases.

Modern rheumatology

Y Adachi, A Tsutsumi, H Murata, H Takemura, Y Chino, R Takahashi, T Ebitsuka, T Sumida

Affiliations

  1. Division of Rheumatology, Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba , 1-1-1 Tennodai, Tsukuba 305-8575 , Japan.

PMID: 24387124 DOI: 10.3109/s101650300015

Abstract

Abstract We describe two cases of Behçet's disease associated with myelodysplastic syndrome (MDS) with trisomy 8. Both cases developed ulceration in the cecum as a gastrointestinal complication of Behçet's disease, after a diagnosis of MDS. We summarized recent case reports of Behçet's disease associated with myelodysplastic syndrome, and studied the clinical manifestations. Most cases showed trisomy 8 as a chromosomal abnormality. Gastrointestinal involvement without eye lesions seems to be characteristic of Behçet's disease associated with MDS.

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