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Peñalva MA, Espeso E, Pérez-Esteban B, et al. Expression of fungal genes involved in penicllin biosynthesis. World J Microbiol Biotechnol. 1993;9(4):461-7doi: 10.1007/BF00328034.
Peñalva, M. A., Espeso, E., Pérez-Esteban, B., Orejas, M., Fernández-Cañón, J. M., & Martínez-Blanco, H. (1993). Expression of fungal genes involved in penicllin biosynthesis. World journal of microbiology & biotechnology, 9(4), 461-7. https://doi.org/10.1007/BF00328034
Peñalva, M A, et al. "Expression of fungal genes involved in penicllin biosynthesis." World journal of microbiology & biotechnology vol. 9,4 (1993): 461-7. doi: https://doi.org/10.1007/BF00328034
Peñalva MA, Espeso E, Pérez-Esteban B, Orejas M, Fernández-Cañón JM, Martínez-Blanco H. Expression of fungal genes involved in penicllin biosynthesis. World J Microbiol Biotechnol. 1993 Jul;9(4):461-7. doi: 10.1007/BF00328034. PMID: 24420113.
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World J Microbiol Biotechnol. 1993 Jul;9(4):461-7. doi: 10.1007/BF00328034.

Expression of fungal genes involved in penicllin biosynthesis.

World journal of microbiology & biotechnology

M A Peñalva, E Espeso, B Pérez-Esteban, M Orejas, J M Fernández-Cañón, H Martínez-Blanco

Affiliations

  1. Centro de Investigaciones Biológicas del C.S.I.C., Velázquez 144, 28006, Madrid, Spain.

PMID: 24420113 DOI: 10.1007/BF00328034

Abstract

Carbon catabolite repression and pH regulation are regulatory circuits with a wide domain of action in the Plectomycetes. Penicillin biosynthesis is one of the pathways which are under their control. The conclusions obtained so far, which are based on studies of the genetic and molecular regulation of the penicillin pathway of Aspergillus nidulans, would have been much harder to produce using an organism such as Penicillium chrysogenum (the industrial penicillin producer). However, A. nidulans and P. chrysogenum are close in terms of their phylogeny and one can reasonably predict that the conclusions about A. nidulans, which are summarized in this review and which are of unquestionable biotechnological relevance, will be extrapolable to the industrial organism.

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