Display options
Cite
Rustad JK, Stern TA, Hebert KA, et al. Diagnosis and treatment of depression in patients with congestive heart failure: a review of the literature. Prim Care Companion CNS Disord. 2013;15(4)doi: 10.4088/PCC.13r01511.
Rustad, J. K., Stern, T. A., Hebert, K. A., & Musselman, D. L. (2013). Diagnosis and treatment of depression in patients with congestive heart failure: a review of the literature. The primary care companion for CNS disorders, 15(4), . https://doi.org/10.4088/PCC.13r01511
Rustad, James K, et al. "Diagnosis and treatment of depression in patients with congestive heart failure: a review of the literature." The primary care companion for CNS disorders vol. 15,4 (2013). doi: https://doi.org/10.4088/PCC.13r01511
Rustad JK, Stern TA, Hebert KA, Musselman DL. Diagnosis and treatment of depression in patients with congestive heart failure: a review of the literature. Prim Care Companion CNS Disord. 2013;15(4). doi: 10.4088/PCC.13r01511. Epub 2013 Aug 15. PMID: 24392265; PMCID: PMC3869617.
Copy Download .nbib Format: NLM
Share it on

Prim Care Companion CNS Disord. 2013;15(4). doi: 10.4088/PCC.13r01511. Epub 2013 Aug 15.

Diagnosis and treatment of depression in patients with congestive heart failure: a review of the literature.

The primary care companion for CNS disorders

James K Rustad, Theodore A Stern, Kathy A Hebert, Dominique L Musselman

Affiliations

  1. Department of Psychiatry and Behavioral Medicine, Morsani College of Medicine, University of South Florida, Tampa, and Department of Psychiatry, University of Central Florida College of Medicine, Orlando (Dr Rustad); Department of Psychiatry, Massachusetts General Hospital/Harvard Medical School, Boston (Dr Stern); Departments of Medicine (Ms Hebert) and Psychiatry (Dr Musselman), University of Miami/Miller School of Medicine, Miami, Florida.

PMID: 24392265 PMCID: PMC3869617 DOI: 10.4088/PCC.13r01511

Abstract

CONTEXT: Major depressive disorder (MDD) can be challenging to diagnose in patients with congestive heart failure, who often suffer from fatigue, insomnia, weight changes, and other neurovegetative symptoms that overlap with those of depression. Pathophysiologic mechanisms (eg, inflammation, autonomic nervous system dysfunction, cardiac arrhythmias, and altered platelet function) connect depression and congestive heart failure.

OBJECTIVE: We sought to review the prevalence, diagnosis, neurobiology, and treatment of depression associated with congestive heart failure.

DATA SOURCES: A search of all English-language articles between January 2003 and January 2013 was conducted using the search terms congestive heart failure and depression.

STUDY SELECTION: We found 1,498 article abstracts and 19 articles (meta-analyses, systematic reviews, and original research articles) that were selected for inclusion, as they contained information about our focus on diagnosis, treatment, and pathophysiology of depression associated with congestive heart failure. The search was augmented with manual review of reference lists of articles from the initial search. Articles selected for review were determined by author consensus.

DATA EXTRACTION: The prevalence, diagnosis, neurobiology, and treatment of depression associated with congestive heart failure were reviewed. Particular attention was paid to the safety, efficacy, and tolerability of antidepressant medications commonly used to treat depression and how their side-effect profiles impact the pathophysiology of congestive heart failure. Drug-drug interactions between antidepressant medications and medications used to treat congestive heart failure were examined.

RESULTS: MDD is highly prevalent in patients with congestive heart failure. Moreover, the prevalence and severity of depression correlate with the degree of cardiac dysfunction and development of congestive heart failure. Depression increases the risk of congestive heart failure, particularly in those patients with coronary artery disease , and is associated with a poorer quality of life, increased use of health care resources, more frequent adverse clinical events and hospitalizations, and twice the risk of mortality.

CONCLUSIONS: At present, limited empirical data exist with regard to treatment of depression in the increasingly large population of patients with congestive heart failure. Evidence reveals that both psychotherapeutic treatment (eg, cognitive-behavioral therapy) and pharmacologic treatment (eg, use of the selective serotonin reuptake inhibitor sertraline) are safe and effective in reducing depression severity in patients with cardiovascular disease. Collaborative care programs featuring interventions that work to improve adherence to medical and psychiatric treatments improve both cardiovascular disease and depression outcomes. Depression rating scales such as the 9-item Patient Health Questionnaire should be used to monitor therapeutic efficacy.

References

  1. JAMA. 1993 Oct 20;270(15):1819-25 - PubMed
  2. Acta Psychiatr Scand. 1986 May;73(5):544-8 - PubMed
  3. Psychosom Med. 2005 May-Jun;67 Suppl 1:S54-7 - PubMed
  4. Psychosom Med. 2005 May-Jun;67 Suppl 1:S37-41 - PubMed
  5. J Clin Psychiatry. 1992 Sep;53 Suppl:25-31 - PubMed
  6. Circulation. 2003 Mar 11;107(9):1278-83 - PubMed
  7. Eur J Heart Fail. 2005 Mar 2;7(2):261-7 - PubMed
  8. Cleve Clin J Med. 2011 Aug;78 Suppl 1:S4-12 - PubMed
  9. Ann Intern Med. 2001 Nov 6;135(9):825-34 - PubMed
  10. Med Care. 2001 Aug;39(8):785-99 - PubMed
  11. Arch Gen Psychiatry. 1965 Jan;12:63-70 - PubMed
  12. J Am Coll Cardiol. 2001 Jul;38(1):199-205 - PubMed
  13. J Clin Psychiatry. 2010 Dec;71(12):1565-75 - PubMed
  14. Circulation. 1993 Jun;87(6 Suppl):VI40-8 - PubMed
  15. Respir Care. 2006 Apr;51(4):403-12 - PubMed
  16. Eur Heart J. 2005 Dec;26(24):2650-6 - PubMed
  17. J Clin Psychopharmacol. 2006 Dec;26(6):579-86 - PubMed
  18. Eur J Heart Fail. 2002 Aug;4(4):541-51 - PubMed
  19. Am J Psychiatry. 1994 May;151(5):790-1 - PubMed
  20. Heart Int. 2011 Oct 03;6(2):e14 - PubMed
  21. Heart Fail Rev. 2009 Sep;14(3):171-82 - PubMed
  22. Gen Hosp Psychiatry. 1998 Jan;20(1):29-43 - PubMed
  23. Nat Rev Cardiol. 2012 Sep;9(9):526-39 - PubMed
  24. Heart Lung. 2009 Sep-Oct;38(5):410-8 - PubMed
  25. Am Heart J. 2002 Oct;144(4):597-607 - PubMed
  26. JAMA. 1998 Jan 28;279(4):287-91 - PubMed
  27. Am J Respir Crit Care Med. 2003 Apr 1;167(7):958-61 - PubMed
  28. Circulation. 2007 Apr 3;115(13):1754-61 - PubMed
  29. Am J Cardiol. 2001 Aug 15;88(4):337-41 - PubMed
  30. Am J Cardiol. 1975 Jul;36(1):45-9 - PubMed
  31. J Clin Psychiatry. 2005 Feb;66(2):253-9 - PubMed
  32. Arch Intern Med. 1989 Aug;149(8):1785-9 - PubMed
  33. Eur J Heart Fail. 2012 Aug;14(8):803-69 - PubMed
  34. J Am Coll Cardiol. 2010 Aug 24;56(9):692-9 - PubMed
  35. J Clin Psychopharmacol. 1983 Dec;3(6):368-72 - PubMed
  36. Biol Psychiatry. 2003 Aug 1;54(3):227-40 - PubMed
  37. JAMA. 2008 Nov 12;300(18):2161-71 - PubMed
  38. Circ Heart Fail. 2009 Nov;2(6):608-15 - PubMed
  39. Eur Heart J. 1998 Jun;19 Suppl F:F56-61 - PubMed
  40. J Gen Intern Med. 2006 Jan;21(1):30-8 - PubMed
  41. Arch Intern Med. 2001 Jul 23;161(14):1725-30 - PubMed
  42. Med Care. 2005 Jul;43(7):667-75 - PubMed
  43. Psychosom Med. 2003 Mar-Apr;65(2):181-93 - PubMed
  44. Milbank Q. 1996;74(4):511-44 - PubMed
  45. Circulation. 1990 Aug;82(2 Suppl):I103-13 - PubMed
  46. N Engl J Med. 1984 Sep 27;311(13):819-23 - PubMed
  47. Eur Heart J. 1998 Jun;19 Suppl F:F72-80 - PubMed
  48. Psychosomatics. 2012 Jul-Aug;53(4):339-46 - PubMed
  49. Arch Intern Med. 2002 Sep 9;162(16):1860-6 - PubMed
  50. Br J Soc Clin Psychol. 1967 Dec;6(4):278-96 - PubMed
  51. J Clin Psychiatry. 2003;64 Suppl 1:5-12 - PubMed
  52. J Am Coll Cardiol. 2009 Apr 21;53(16):1440-7 - PubMed
  53. Int J Psychiatry Med. 1998;28(3):273-91 - PubMed
  54. Circulation. 2006 Sep 12;114(11):1202-13 - PubMed
  55. Diabetes Care. 2004 Feb;27(2):596-601 - PubMed
  56. Br J Psychiatry. 1979 Apr;134:382-9 - PubMed
  57. JAMA. 2002 Aug 14;288(6):701-9 - PubMed
  58. J Am Coll Cardiol. 2004 May 5;43(9):1542-9 - PubMed
  59. Am J Cardiol. 1993 May 1;71(12):1106-7 - PubMed
  60. Gen Hosp Psychiatry. 1996 Jan;18(1):61-5 - PubMed
  61. Circulation. 2011 Mar 1;123(8):933-44 - PubMed
  62. J ECT. 2011 Sep;27(3):207-13 - PubMed
  63. Proc (Bayl Univ Med Cent). 2013 Jan;26(1):6-9 - PubMed
  64. Congest Heart Fail. 2003 May-Jun;9(3):163-9 - PubMed
  65. Arch Gen Psychiatry. 1998 Jul;55(7):580-92 - PubMed
  66. J Clin Psychiatry. 2003 Feb;64(2):208-14 - PubMed
  67. J ECT. 2001 Dec;17(4):244-53 - PubMed
  68. J Neurol Neurosurg Psychiatry. 1960 Feb;23:56-62 - PubMed
  69. Circulation. 2009 Jul 14;120(2):134-40, 3p following 140 - PubMed
  70. Psychopharmacol Bull. 1973 Jan;9(1):13-28 - PubMed
  71. JAMA. 2012 Aug 1;308(5):465-74 - PubMed
  72. J Am Coll Cardiol. 2006 Oct 17;48(8):1527-37 - PubMed
  73. Cardiol Rev. 2011 May-Jun;19(3):130-42 - PubMed
  74. Prim Care Companion J Clin Psychiatry. 2009;11(3):103-9 - PubMed
  75. Med Care. 2004 Dec;42(12):1194-201 - PubMed
  76. Eur J Clin Invest. 2011 Dec;41(12):1310-7 - PubMed
  77. Pharmacotherapy. 2004 Oct;24(10):1306-10 - PubMed
  78. Arch Intern Med. 2000 May 8;160(9):1354-60 - PubMed
  79. Circulation. 2002 Mar 5;105(9):1049-53 - PubMed
  80. J Psychosom Res. 2010 Aug;69(2):119-31 - PubMed
  81. Heart Fail Clin. 2011 Jan;7(1):23-38 - PubMed
  82. Fam Syst Health. 2010 Jun;28(2):114-29 - PubMed
  83. Am J Cardiol. 2004 Dec 15;94(12):1577-80 - PubMed
  84. Perspect Psychiatr Care. 2010 Apr;46(2):119-26 - PubMed
  85. J Clin Psychiatry. 2007;68 Suppl 8:17-25 - PubMed
  86. Psychosom Med. 2003 Jan-Feb;65(1):119-28 - PubMed
  87. Med Care. 1992 Jun;30(6):473-83 - PubMed
  88. Heart Fail Rev. 2009 Mar;14(1):7-12 - PubMed
  89. J Consult Clin Psychol. 1986 Feb;54(1):54-9 - PubMed
  90. Eff Clin Pract. 1998 Aug-Sep;1(1):2-4 - PubMed
  91. Am Heart J. 2010 May;159(5):780-7 - PubMed
  92. Psychosom Med. 2002 Jan-Feb;64(1):6-12 - PubMed
  93. N Engl J Med. 2010 Dec 30;363(27):2611-20 - PubMed
  94. Psychosom Med. 1988 Nov-Dec;50(6):627-33 - PubMed
  95. Prog Cardiovasc Nurs. 2008 Winter;23(1):12-7 - PubMed
  96. N Engl J Med. 1995 Nov 2;333(18):1190-5 - PubMed
  97. Gen Hosp Psychiatry. 2007 Sep-Oct;29(5):417-24 - PubMed
  98. BMJ. 2001 Mar 31;322(7289):746-7 - PubMed
  99. J Clin Psychiatry. 2003 Aug;64(8):875-82 - PubMed
  100. J Am Coll Cardiol. 2006 Dec 5;48(11):2204-8 - PubMed
  101. Circulation. 1987 May;75(5 Pt 2):IV80-92 - PubMed
  102. Am J Cardiol. 2005 Oct 15;96(8):1076-81 - PubMed
  103. Depression. 1996;4(2):57-62 - PubMed
  104. Lancet. 2001 Nov 24;358(9295):1766-71 - PubMed
  105. Heart Fail Rev. 2009 Mar;14(1):35-50 - PubMed
  106. Am J Psychiatry. 1997 Oct;154(10):1376-83 - PubMed
  107. J Card Fail. 2009 Sep;15(7):572-9 - PubMed
  108. Circulation. 2008 Oct 21;118(17):1768-75 - PubMed
  109. J Clin Psychopharmacol. 2005 Oct;25(5):480-4 - PubMed
  110. Arch Intern Med. 2001 Aug 13-27;161(15):1849-56 - PubMed
  111. J Am Board Fam Pract. 2005 Nov-Dec;18(6):520-7 - PubMed
  112. Expert Opin Drug Metab Toxicol. 2011 Sep;7(9):1065-82 - PubMed
  113. Psychosomatics. 2003 Sep-Oct;44(5):367-73 - PubMed
  114. Eur J Heart Fail. 2007 Dec;9(12):1212-22 - PubMed
  115. J Gen Intern Med. 2001 Sep;16(9):606-13 - PubMed
  116. Med Care. 2003 Nov;41(11):1284-92 - PubMed
  117. J Clin Psychol. 2009 May;65(5):467-87 - PubMed
  118. Am J Cardiol. 1995 Jun 1;75(16):1151-7 - PubMed
  119. Congest Heart Fail. 2012 Mar-Apr;18(2):107-11 - PubMed
  120. N Engl J Med. 2008 Sep 18;359(12):1202-5 - PubMed
  121. Am J Psychiatry. 1998 May;155(5):660-5 - PubMed
  122. Br J Psychiatry. 2004 Jan;184:41-7 - PubMed
  123. J ECT. 2004 Mar;20(1):13-20 - PubMed
  124. Psychosom Med. 2007 Jan;69(1):23-9 - PubMed
  125. Am Heart J. 2003 Oct;146(4):729-35 - PubMed
  126. JAMA. 2003 Jun 18;289(23):3095-105 - PubMed

Publication Types