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Ulla M, Gentile E, Yeyati EL, et al. Pneumo-CT assessing response to neoadjuvant therapy in esophageal cancer: Imaging-pathological correlation. World J Gastrointest Oncol. 2013;5(12):222-9doi: 10.4251/wjgo.v5.i12.222.
Ulla, M., Gentile, E., Yeyati, E. L., Diez, M. L., Cavadas, D., Garcia-Monaco, R. D., & Ros, P. R. (2013). Pneumo-CT assessing response to neoadjuvant therapy in esophageal cancer: Imaging-pathological correlation. World journal of gastrointestinal oncology, 5(12), 222-9. https://doi.org/10.4251/wjgo.v5.i12.222
Ulla, Marina, et al. "Pneumo-CT assessing response to neoadjuvant therapy in esophageal cancer: Imaging-pathological correlation." World journal of gastrointestinal oncology vol. 5,12 (2013): 222-9. doi: https://doi.org/10.4251/wjgo.v5.i12.222
Ulla M, Gentile E, Yeyati EL, Diez ML, Cavadas D, Garcia-Monaco RD, Ros PR. Pneumo-CT assessing response to neoadjuvant therapy in esophageal cancer: Imaging-pathological correlation. World J Gastrointest Oncol. 2013 Dec 15;5(12):222-9. doi: 10.4251/wjgo.v5.i12.222. PMID: 24363830; PMCID: PMC3868717.
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World J Gastrointest Oncol. 2013 Dec 15;5(12):222-9. doi: 10.4251/wjgo.v5.i12.222.

Pneumo-CT assessing response to neoadjuvant therapy in esophageal cancer: Imaging-pathological correlation.

World journal of gastrointestinal oncology

Marina Ulla, Ernestina Gentile, Ezequiel Levy Yeyati, Maria L Diez, Demetrio Cavadas, Ricardo D Garcia-Monaco, Pablo R Ros

Affiliations

  1. Marina Ulla, Ernestina Gentile, Ezequiel Levy Yeyati, Maria L Diez, Demetrio Cavadas, Ricardo D Garcia-Monaco, Pablo R Ros, Department of Radiology, Hospital Italiano de Buenos Aires, Gascón 450, Argentina.

PMID: 24363830 PMCID: PMC3868717 DOI: 10.4251/wjgo.v5.i12.222

Abstract

Pneumo-computed tomography (PnCT) is a technique primarily developed and used to study stenotic lesions of the esophagus, gastroesophageal junction and stomach for pre-surgical planning. It helps to define both upper and lower borders of neoplasms located in the aforementioned areas. It achieves maximum lumen distension with CO2 highlighting thickened areas of the esophageal wall, thus allowing an accurate quantification of their extents. Although there are other alternatives for distension (oral contrast agents, water and effervescent granules), they may be suboptimal. Patients with locally advanced esophageal cancer have a dismal prognosis despite surgical resection. Therefore, neoadjuvant treatment strategies using radiation therapy and chemotherapy were developed to improve survival. Neoadjuvant therapy improves esophageal tumor prognosis in a substantial proportion of patients, and the use of imaging techniques is mandatory to detect their response. PnCT combined with virtual endoscopy and multiplanar reconstruction enhances morphologic details in esophageal cancer, and thus would allow an improved assessment of response to neoadjuvant treatment. Therefore, more information could be provided to assess the efficacy of pre-surgical treatment. We describe the potential use of PnCT to assess the response to neoadjuvant therapy in esophageal cancer with an imaging pathologic correlation.

Keywords: 64-multidetector computed tomography; Assessment response; Cancer; Esophagus; Neoadjuvant treatment

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