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Malayan J, Selvaraj B, Warrier A, et al. Anti-mumps virus activity by extracts of Mimosa pudica, a unique Indian medicinal plant. Indian J Virol. 2013;24(2):166-73doi: 10.1007/s13337-013-0143-2.
Malayan, J., Selvaraj, B., Warrier, A., Shanmugam, S., Mathayan, M., & Menon, T. (2013). Anti-mumps virus activity by extracts of Mimosa pudica, a unique Indian medicinal plant. Indian journal of virology : an official organ of Indian Virological Society, 24(2), 166-73. https://doi.org/10.1007/s13337-013-0143-2
Malayan, Jeevan, et al. "Anti-mumps virus activity by extracts of Mimosa pudica, a unique Indian medicinal plant." Indian journal of virology : an official organ of Indian Virological Society vol. 24,2 (2013): 166-73. doi: https://doi.org/10.1007/s13337-013-0143-2
Malayan J, Selvaraj B, Warrier A, Shanmugam S, Mathayan M, Menon T. Anti-mumps virus activity by extracts of Mimosa pudica, a unique Indian medicinal plant. Indian J Virol. 2013 Sep;24(2):166-73. doi: 10.1007/s13337-013-0143-2. Epub 2013 Aug 10. PMID: 24426272; PMCID: PMC3784913.
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Indian J Virol. 2013 Sep;24(2):166-73. doi: 10.1007/s13337-013-0143-2. Epub 2013 Aug 10.

Anti-mumps virus activity by extracts of Mimosa pudica, a unique Indian medicinal plant.

Indian journal of virology : an official organ of Indian Virological Society

Jeevan Malayan, Balaji Selvaraj, Aparna Warrier, Sambantham Shanmugam, Manikannan Mathayan, Thangam Menon

Affiliations

  1. Department of Microbiology, Dr. ALM PG Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai, 600113 India.
  2. Department of Genetics, Dr. ALM PG Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai, 600113 India.

PMID: 24426272 PMCID: PMC3784913 DOI: 10.1007/s13337-013-0143-2

Abstract

Mumps is an acute and self-limiting disease characterized by parotitis, however in some cases it leads to aseptic meningitis, deafness, encephalitis and orchitis, which is a serious health concern. MMR vaccination was successful in eradicating the disease however, recent reports question the efficacy of MMR vaccine and countless outbreaks are observed in vaccinated populations throughout the world. Lack of specific treatment methods for mumps infection and inefficiency of MMR vaccine in vaccinated populations accentuates the need for the development of novel drugs to control mumps virus mediated serious infections. It was with this backdrop of information that the anti-mumps virus activity of Mimosa pudica was evaluated. Suspected mumps cases were collected to isolate a standard mumps virus by systematic laboratory testing which included IgM antibody assays, virus isolation, RT-PCR and phylogenetic analysis. The virus was quantified by TCID50 assay and anti-mumps virus property was evaluated by CPE reduction assay and cytotoxicity of the extract was measured by MTT assay and phytochemical analysis was done by gas chromatography-mass spectroscopy. The RT-PCR and phylogenetic tree analysis of the SH gene sequence of the clinical isolate showed it to be mumps virus genotype C. 150 μg/ml concentration of M. pudica completely inhibited mumps virus and the drug was found to be non-toxic up to 2 mg/ml. M. pudica was thus found to be a potent inhibitor of MuV.

Keywords: CPE; Genotype C; M. pudica; MMR vaccine; Mumps virus; Vero cells

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