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Clin Exp Vaccine Res. 2014 Jan;3(1):37-41. doi: 10.7774/cevr.2014.3.1.37. Epub 2013 Dec 18.

Prophylactic and therapeutic vaccines for obesity.

Clinical and experimental vaccine research

Ha-Na Na, Hun Kim, Jae-Hwan Nam

Affiliations

  1. Department of Infection and Obesity, Pennington Biomedical Research Center, Baton Rouge, LA, USA.
  2. SK Chemicals, Seongnam, Korea.
  3. Department of Biotechnology, The Catholic University of Korea, Bucheon, Korea.

PMID: 24427761 PMCID: PMC3890448 DOI: 10.7774/cevr.2014.3.1.37

Abstract

Chronic diseases such as obesity and diabetes are major causes of death and disability throughout the world. Many causes are known to trigger these chronic diseases, and infectious agents such as viruses are also pathological factors. In particular, it is considered that adenovirus 36 infections may be associated with obesity. If this is the case, a vaccine against adenovirus 36 may be a form of prophylaxis to combat obesity. Other types of therapeutic vaccines to combat obesity are also being developed. Recently, hormones such as glucagon-like peptide-1, ghrelin, and peptide YY have been studied as treatments to prevent obesity. This review describes the ongoing development of therapeutic vaccines to treat obesity, and the possibility of using inactivated adenovirus 36 as a vaccine and an anti-obesity agent.

Keywords: Adenovirus 36; Obesity; Vaccine

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