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Saleem MT, Chetty MC, Kavimani S. Putative antioxidant property of sesame oil in an oxidative stress model of myocardial injury. J Cardiovasc Dis Res. 2013;4(3):177-81doi: 10.1016/j.jcdr.2013.07.001.
Saleem, M. T., Chetty, M. C., & Kavimani, S. (2013). Putative antioxidant property of sesame oil in an oxidative stress model of myocardial injury. Journal of cardiovascular disease research, 4(3), 177-81. https://doi.org/10.1016/j.jcdr.2013.07.001
Saleem, Mohamed T S, et al. "Putative antioxidant property of sesame oil in an oxidative stress model of myocardial injury." Journal of cardiovascular disease research vol. 4,3 (2013): 177-81. doi: https://doi.org/10.1016/j.jcdr.2013.07.001
Saleem MT, Chetty MC, Kavimani S. Putative antioxidant property of sesame oil in an oxidative stress model of myocardial injury. J Cardiovasc Dis Res. 2013 Sep;4(3):177-81. doi: 10.1016/j.jcdr.2013.07.001. Epub 2013 Nov 01. PMID: 24396257; PMCID: PMC3849287.
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J Cardiovasc Dis Res. 2013 Sep;4(3):177-81. doi: 10.1016/j.jcdr.2013.07.001. Epub 2013 Nov 01.

Putative antioxidant property of sesame oil in an oxidative stress model of myocardial injury.

Journal of cardiovascular disease research

Mohamed T S Saleem, Madhusudhana C Chetty, S Kavimani

Affiliations

  1. Jawaharlal Nehru Technological University, Kakinada & Department of Pharmacology, Annamacharya College of Pharmacy, Andhra Pradesh 516126, India.
  2. Department of Biotechnology, Annamacharya College of Pharmacy, Rajampet 516126, India.
  3. Department of Pharmacology, Mother Theresa Post Graduate and Research Institute of Health Sciences, Puducherry 605006, India.

PMID: 24396257 PMCID: PMC3849287 DOI: 10.1016/j.jcdr.2013.07.001

Abstract

BACKGROUND: Sesame oil is a potent antioxidant dietary source for human health. Oxidative stress through generation of free radicals damages the myocardium in different experimental condition. The present research was designed to evaluate the antioxidant property of chronic oral administration of sesame oil against isoproterenol induced myocardial injury.

METHODS AND RESULTS: Male Wistar albino rats were randomly divided into five groups (n = 6) and treated as per treatment protocol with two different doses of sesame oil (5 and 10 ml/kg b.w.) orally for thirty days. At the end of the treatment all the rats (except control rats) were administered with isoproterenol (85 mg/kg) two consecutive days and subjected to biochemical and histopathological estimation. Isoproterenol (group ISO) induced the oxidative myocardial damage via alteration in the endogenous antioxidant enzymes and myocardial marker enzymes. Sesame oil in both the dose (group S1 and S2) shows protective mechanism via decreasing thiobarbituric acid reactive substance (TBARS) and enhancing the endogenous antioxidant enzymes (reduced glutathione (GSH), superoxide dismutase (SOD) and Catalase). Sesame oil also increased the lactate dehydrogenase (LDH), creatine kinase (CK) and aspartate transaminase (AST) as a myocardial marker enzyme in heart homogenate. As histologically evident isoproterenol induced myocardial injury was well preserved by the chronic administration of sesame oil. The protective role of sesame oil was compared with the reference standard α-tocopherol (group S3) also showing the similar effect.

CONCLUSION: From this finding it has been concluded that chronic administration of sesame oil offers cardio protective action via putative antioxidant property.

Keywords: Antioxidants; Ischemic reperfusion injury; Myocardial infarction; Neutraceutical

References

  1. J Food Sci Technol. 2012 Apr;49(2):173-83 - PubMed
  2. BMC Complement Altern Med. 2006 Sep 20;6:32 - PubMed
  3. Can J Physiol Pharmacol. 1997 Dec;75(12):1300-11 - PubMed
  4. Pharmacol Res. 1998 Oct;38(4):297-303 - PubMed
  5. Indian J Exp Biol. 1980 Dec;18(12):1443-5 - PubMed
  6. Cardiovasc Res. 1995 Jan;29(1):133-40 - PubMed
  7. Mol Cell Biochem. 2009 Aug;328(1-2):1-8 - PubMed
  8. J Med Lab Technol. 1959 Oct;16:265-72 - PubMed
  9. Drug Chem Toxicol. 2011 Apr;34(2):116-9 - PubMed
  10. Cardiovasc Res. 2007 Jun 1;74(3):445-55 - PubMed
  11. Arch Biochem Biophys. 1959 May;82(1):70-7 - PubMed
  12. Int J Cardiol. 2008 Jan 11;123(2):102-7 - PubMed
  13. Int J Food Sci Nutr. 2012 Sep;63(6):674-8 - PubMed
  14. Proc Natl Acad Sci U S A. 1990 Jul;87(13):5006-10 - PubMed
  15. BMC Pharmacol. 2002 Aug 16;2:16 - PubMed
  16. Anal Biochem. 1976 May 7;72:248-54 - PubMed
  17. Am J Physiol. 1995 Oct;269(4 Pt 1):C907-16 - PubMed
  18. Life Sci. 2007 Nov 30;81(23-24):1615-21 - PubMed
  19. Eur J Prev Cardiol. 2013 Apr;20(2):202-8 - PubMed
  20. Hum Exp Toxicol. 2007 Dec;26(12):933-8 - PubMed
  21. J Mol Cell Cardiol. 1995 Jan;27(1):181-93 - PubMed
  22. J Am Soc Nephrol. 1997 Jun;8(6):1028-33 - PubMed
  23. Pharmacol Res. 2004 Sep;50(3):231-6 - PubMed
  24. Neurochem Res. 2012 Mar;37(3):516-26 - PubMed
  25. Indian J Exp Biol. 1988 Mar;26(3):235-6 - PubMed
  26. Anal Biochem. 1979 Jun;95(2):351-8 - PubMed
  27. J Adv Pharm Technol Res. 2013 Apr;4(2):94-100 - PubMed
  28. Toxicol Pathol. 2007 Apr;35(3):418-23 - PubMed
  29. Circulation. 1995 Jan 1;91(1):10-5 - PubMed
  30. Pharmacol Res. 2002 Sep;46(3):213-19 - PubMed
  31. Med Hypotheses. 1998 Aug;51(2):153-63 - PubMed
  32. Cardiovasc Res. 1993 Apr;27(4):578-84 - PubMed
  33. Redox Rep. 1999;4(6):291-9 - PubMed
  34. Eur J Pharm Sci. 2004 Nov;23(3):277-85 - PubMed
  35. Indian J Biochem Biophys. 1984 Apr;21(2):130-2 - PubMed

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