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Narumiya S. Physiology and pathophysiology of prostanoid receptors. Proc Jpn Acad Ser B Phys Biol Sci. 2007;83(9):296-319doi: 10.2183/pjab/83.296.
Narumiya, S. (2007). Physiology and pathophysiology of prostanoid receptors. Proceedings of the Japan Academy. Series B, Physical and biological sciences, 83(9), 296-319. https://doi.org/10.2183/pjab/83.296
Narumiya, Shuh. "Physiology and pathophysiology of prostanoid receptors." Proceedings of the Japan Academy. Series B, Physical and biological sciences vol. 83,9 (2007): 296-319. doi: https://doi.org/10.2183/pjab/83.296
Narumiya S. Physiology and pathophysiology of prostanoid receptors. Proc Jpn Acad Ser B Phys Biol Sci. 2007 Dec;83(9):296-319. doi: 10.2183/pjab/83.296. PMID: 24367153; PMCID: PMC3859365.
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Proc Jpn Acad Ser B Phys Biol Sci. 2007 Dec;83(9):296-319. doi: 10.2183/pjab/83.296.

Physiology and pathophysiology of prostanoid receptors.

Proceedings of the Japan Academy. Series B, Physical and biological sciences

Shuh Narumiya

Affiliations

  1. Department of Pharmacology, Kyoto University Faculty of Medicine, Kyoto, Japan . ; Recipient of the Imperial Prize and the Japan Academy Prize in 2006.

PMID: 24367153 PMCID: PMC3859365 DOI: 10.2183/pjab/83.296

Abstract

Prostanoids, consisting of prostaglandins (PGs) and thromboxanes (TXs), are oxygenated products of C20 unsaturated fatty acids. They include PGD2, PGE2, PGF2 α , PGI2, and TXA2. Given that aspirin-like nonsteroidal anti-inflammatory drugs exert their actions by suppressing prostanoid production, prostanoids have been implicated in processes inhibited by these drugs, including inflammation, fever, and pain. Prostanoids also contribute to vascular homeostasis, reproduction, and regulation of kidney and gastrointestinal functions. How prostanoids exert such a variety of actions had remained unclear, however. Prostanoids are released outside of cells immediately after their synthesis and exert their actions by binding to receptors on target cells. We have identified a family of eight types or subtypes of G protein-coupled receptors that mediate prostanoid actions. Another G protein-coupled receptor was also identified as an additional receptor for PGD2. Genes for these receptors have been individually disrupted in mice, and analyses of these knockout mice have not only elucidated the molecular and cellular mechanisms of known prostanoid actions but also revealed previously unknown actions. In this article, I review the physiological and pathophysiological roles of prostanoids and their receptors revealed by these studies.

Keywords: G protein–coupled receptor; cyclooxygenase; prostaglandin; thromboxane

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