Display options
Cite
Su WH, Hildesheim A, Chang YS. Human leukocyte antigens and epstein-barr virus-associated nasopharyngeal carcinoma: old associations offer new clues into the role of immunity in infection-associated cancers. Front Oncol. 2013;3:299doi: 10.3389/fonc.2013.00299.
Su, W. H., Hildesheim, A., & Chang, Y. S. (2013). Human leukocyte antigens and epstein-barr virus-associated nasopharyngeal carcinoma: old associations offer new clues into the role of immunity in infection-associated cancers. Frontiers in oncology, 3299. https://doi.org/10.3389/fonc.2013.00299
Su, Wen-Hui, et al. "Human leukocyte antigens and epstein-barr virus-associated nasopharyngeal carcinoma: old associations offer new clues into the role of immunity in infection-associated cancers." Frontiers in oncology vol. 3 (2013): 299. doi: https://doi.org/10.3389/fonc.2013.00299
Su WH, Hildesheim A, Chang YS. Human leukocyte antigens and epstein-barr virus-associated nasopharyngeal carcinoma: old associations offer new clues into the role of immunity in infection-associated cancers. Front Oncol. 2013 Dec 09;3:299. doi: 10.3389/fonc.2013.00299. PMID: 24367763; PMCID: PMC3856645.
Copy Download .nbib Format: NLM
Share it on

Front Oncol. 2013 Dec 09;3:299. doi: 10.3389/fonc.2013.00299.

Human leukocyte antigens and epstein-barr virus-associated nasopharyngeal carcinoma: old associations offer new clues into the role of immunity in infection-associated cancers.

Frontiers in oncology

Wen-Hui Su, Allan Hildesheim, Yu-Sun Chang

Affiliations

  1. Department of Biomedical Sciences, Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University , Taoyuan , Taiwan ; Chang Gung Molecular Medicine Research Center, Chang Gung University , Taoyuan , Taiwan.
  2. Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute , Bethesda, MD , USA.
  3. Chang Gung Molecular Medicine Research Center, Chang Gung University , Taoyuan , Taiwan.

PMID: 24367763 PMCID: PMC3856645 DOI: 10.3389/fonc.2013.00299

Abstract

Nasopharyngeal carcinoma (NPC) is an Epstein-Barr virus (EBV) associated tumor. In addition to EBV, host genetic factors are believed to be important determinants of NPC risk. Of all genes studies to date, human leukocyte antigen (HLA) genes have shown the most consistent evidence for association with NPC, both from candidate-gene studies and genome-wide association studies (GWAS). In this report we summarize results from recent studies that evaluated the association between HLA and NPC, and discuss whether findings reflect direct causal associations for HLA genes and/or indirect associations that mark causal associations with other genes in the gene-dense major histocompatibility (MHC) region where HLA resides. We also compare GWAS results across cancer sites for which strong hits in the MHC region were observed to generate new hypotheses regarding the role of HLA genes in the development of EBV-associated cancers such as NPC. Of note, we report that MHC associations for EBV-associated cancers (NPC, EBV+ Hodgkin lymphoma) are driven by HLA class I genes. In contrast, MHC associations for other viral-associated cancers (cervical cancer, hepatocellular carcinoma) or other hematopoetic cancers (EBV- Hodgkin lymphoma, leukemia, non-Hodgkin lymphomas) are driven by HLA class II genes, and those for other solid tumors with less clear links to infections (lung, testicular, prostate cancers) are driven by non-HLA genes in the MHC region. Future studies should aim to better understand these patterns.

Keywords: EBV; HLA antigens; genome-wide association study; infection associated cancers; nasopharyngeal carcinoma

References

  1. Nat Genet. 2009 Sep;41(9):1001-5 - PubMed
  2. PLoS Genet. 2012;8(7):e1002791 - PubMed
  3. PLoS Genet. 2012;8(11):e1003103 - PubMed
  4. PLoS Genet. 2013;9(1):e1003147 - PubMed
  5. Nat Genet. 2011 Jul 10;43(8):785-91 - PubMed
  6. Semin Cancer Biol. 2012 Apr;22(2):96-106 - PubMed
  7. Nat Genet. 2013 Aug;45(8):868-76 - PubMed
  8. Leukemia. 2012 May;26(5):902-9 - PubMed
  9. Cancer Epidemiol Biomarkers Prev. 2006 Oct;15(10):1765-77 - PubMed
  10. Nat Genet. 2009 Aug;41(8):873-5 - PubMed
  11. Am J Hum Genet. 2012 Nov 2;91(5):928-34 - PubMed
  12. Blood. 2012 Jul 26;120(4):843-6 - PubMed
  13. Blood. 2012 Nov 15;120(20):4197-204 - PubMed
  14. Nat Genet. 2010 Jul;42(7):599-603 - PubMed
  15. Int J Cancer. 1974 Jan 15;13(1):122-34 - PubMed
  16. J Hum Genet. 2011 Jun;56(6):436-9 - PubMed
  17. PLoS Genet. 2011 Apr;7(4):e1001378 - PubMed
  18. Am J Hum Genet. 2009 Nov;85(5):679-91 - PubMed
  19. Nat Genet. 2010 Aug;42(8):661-4 - PubMed
  20. Microbes Infect. 2004 Apr;6(5):501-12 - PubMed
  21. Nat Genet. 2011 Oct 30;43(12):1215-8 - PubMed
  22. PLoS One. 2012;7(8):e42767 - PubMed
  23. PLoS Genet. 2013;9(1):e1003220 - PubMed
  24. Blood. 2011 Feb 10;117(6):1911-6 - PubMed
  25. Semin Cancer Biol. 2012 Apr;22(2):107-16 - PubMed
  26. Int J Cancer. 2005 Jul 10;115(5):742-6 - PubMed
  27. Nat Genet. 2013 Apr;45(4):385-91, 391e1-2 - PubMed
  28. Nat Genet. 2013 Aug;45(8):918-22 - PubMed
  29. Blood. 2011 Jun 23;117(25):6906-11 - PubMed
  30. Nat Genet. 2011 May;43(5):455-8 - PubMed
  31. Cancer Sci. 2013 Jan;104(1):1-8 - PubMed
  32. J Natl Cancer Inst. 2012 Feb 8;104(3):240-53 - PubMed
  33. Lancet. 1997 Oct 11;350(9084):1087-91 - PubMed
  34. Science. 2010 Dec 10;330(6010):1551-7 - PubMed
  35. Nat Genet. 2013 Jan;45(1):72-5 - PubMed
  36. Nature. 1990 Aug 2;346(6283):470-1 - PubMed
  37. J Hum Genet. 2009 Jul;54(7):392-7 - PubMed
  38. Int J Cancer. 2003 Mar 1;103(6):745-51 - PubMed
  39. Hepatology. 2010 Dec;52(6):2034-43 - PubMed
  40. Nat Genet. 2012 Dec;44(12):1330-5 - PubMed
  41. Blood. 2012 Jan 12;119(2):469-75 - PubMed
  42. Nature. 1970 Dec 12;228(5276):1056-8 - PubMed
  43. Nat Genet. 2010 Dec;42(12):1126-1130 - PubMed
  44. N Engl J Med. 2009 Apr 23;360(17):1759-68 - PubMed
  45. Nat Genet. 2012 Jul 15;44(8):900-3 - PubMed
  46. Am J Hum Genet. 2009 Aug;85(2):194-203 - PubMed
  47. Nat Genet. 2009 Sep;41(9):1006-10 - PubMed
  48. Nat Genet. 2009 Jul;41(7):807-10 - PubMed
  49. J Natl Cancer Inst. 2013 May 1;105(9):624-33 - PubMed
  50. Nat Genet. 2008 Dec;40(12):1407-9 - PubMed
  51. Nat Genet. 2010 Sep;42(9):764-7 - PubMed
  52. Hum Mol Genet. 2013 Oct 15;22(20):4233-8 - PubMed

Publication Types