Display options
Cite
Abdul Wahab A, Maarafiya MM, Soliman A, et al. Serum Leptin and Adiponectin Levels in Obese and Nonobese Asthmatic School Children in relation to Asthma Control. J Allergy (Cairo). 2013;2013:654104doi: 10.1155/2013/654104.
Abdul Wahab, A., Maarafiya, M. M., Soliman, A., Younes, N. B., & Chandra, P. (2013). Serum Leptin and Adiponectin Levels in Obese and Nonobese Asthmatic School Children in relation to Asthma Control. Journal of allergy, 2013654104. https://doi.org/10.1155/2013/654104
Abdul Wahab, Atqah, et al. "Serum Leptin and Adiponectin Levels in Obese and Nonobese Asthmatic School Children in relation to Asthma Control." Journal of allergy vol. 2013 (2013): 654104. doi: https://doi.org/10.1155/2013/654104
Abdul Wahab A, Maarafiya MM, Soliman A, Younes NB, Chandra P. Serum Leptin and Adiponectin Levels in Obese and Nonobese Asthmatic School Children in relation to Asthma Control. J Allergy (Cairo). 2013;2013:654104. doi: 10.1155/2013/654104. Epub 2013 Dec 17. PMID: 24454412; PMCID: PMC3877632.
Copy Download .nbib Format: NLM
Share it on

J Allergy (Cairo). 2013;2013:654104. doi: 10.1155/2013/654104. Epub 2013 Dec 17.

Serum Leptin and Adiponectin Levels in Obese and Nonobese Asthmatic School Children in relation to Asthma Control.

Journal of allergy

Atqah Abdul Wahab, Muna M Maarafiya, Ashraf Soliman, Noura B M Younes, Prem Chandra

Affiliations

  1. Department of Pediatrics, Hamad Medical Corporation, P.O. Box 3050, Doha, Qatar ; Weill Cornell Medical College, Doha, Qatar.
  2. Department of Pediatrics, Hamad Medical Corporation, P.O. Box 3050, Doha, Qatar.
  3. Laboratory Medicine and Pathology, Hamad Medical Corporation, P.O. Box 3050, Doha, Qatar.
  4. Medical Research Center, Hamad Medical Corporation, P.O. Box 3050, Doha, Qatar.

PMID: 24454412 PMCID: PMC3877632 DOI: 10.1155/2013/654104

Abstract

There is growing evidence of a positive correlation between asthma and obesity in children and adults. Leptin and adiponectin regulate several metabolic and inflammatory functions. This study aims to evaluate serum leptin and adiponectin concentrations in asthmatic school children to investigate their association with obesity and the degree of asthma control. Obese asthmatic (OA) and nonobese asthmatic (NOA) children, aged 7 to 14, were randomly enrolled in this prospective study. Data on demographic, anthropometric, serum lipids, and spirometric measures and allergy status were collected and analyzed. Serum leptin was significantly higher (25.8 ± 11.1 versus 8.7 ± 11.1; P < 0.0001) and adiponectin levels were lower (2.5 ± 1.2 versus 5.4 ± 2.9; P < 0.0001) in OA compared to NOA children. The uncontrolled group had higher leptin and lower adiponectin levels compared to well and partially controlled asthma. BMI was positively correlated with leptin (r = 0.79; P < 0.001) and negatively with adiponectin (r = -0.73; P < 0.001). Mean BMI and leptin levels were observed to be higher in girls compared to boys. Stepwise multiple linear regression analysis showed that higher BMI and female gender had significant effect on serum leptin levels. Among asthmatic children higher serum leptin and lower adiponectin levels were significantly associated with obesity and showed no significant association with degree of asthma controls.

References

  1. Am J Rhinol Allergy. 2010 Sep-Oct;24(5):354-8 - PubMed
  2. Eur Respir J. 2004 Sep;24(3):406-12 - PubMed
  3. Allergy. 2009 May;64(5):770-7 - PubMed
  4. Curr Opin Pulm Med. 2007 Jan;13(1):56-62 - PubMed
  5. Biochimie. 2012 Oct;94(10):2180-9 - PubMed
  6. J Allergy Clin Immunol. 2005 Jan;115(1):103-9 - PubMed
  7. Respirology. 2012 Apr;17(3):412-21 - PubMed
  8. Eur Respir J. 2012 Dec;40(6):1324-43 - PubMed
  9. Int J Obes Relat Metab Disord. 1997 Jul;21(7):536-41 - PubMed
  10. J Asthma. 2010 Apr;47(3):257-62 - PubMed
  11. Thorax. 2008 Oct;63(10):877-82 - PubMed
  12. J Allergy Clin Immunol. 2005 May;115(5):925-7 - PubMed
  13. Thorax. 2006 Apr;61(4):300-5 - PubMed
  14. Pediatr Allergy Immunol. 2004 Dec;15(6):523-30 - PubMed
  15. J Allergy Clin Immunol. 2005 May;115(5):897-909; quiz 910 - PubMed
  16. J Clin Invest. 2003 Dec;112(12):1785-8 - PubMed
  17. J Allergy Clin Immunol. 2004 Aug;114(2):254-9 - PubMed
  18. Eur Respir J. 2013 Oct;42(4):1012-9 - PubMed
  19. Lancet. 2008 Sep 20;372(9643):1107-19 - PubMed
  20. Biochem Biophys Res Commun. 2004 Oct 15;323(2):630-5 - PubMed
  21. Chest. 2008 Aug;134(2):317-323 - PubMed
  22. Chest. 2009 Feb;135(2):287-294 - PubMed
  23. Obes Rev. 2013 Mar;14(3):222-31 - PubMed
  24. Allergy. 2007 Oct;62(10):1205-13 - PubMed
  25. Pediatr Allergy Immunol. 2008 Sep;19(6):535-40 - PubMed
  26. Adv Med Sci. 2013;58(1):15-21 - PubMed
  27. Am J Respir Crit Care Med. 2004 Apr 1;169(7):873-81 - PubMed
  28. Am J Respir Crit Care Med. 2006 Jul 15;174(2):112-9 - PubMed
  29. J Allergy Clin Immunol. 2006 Aug;118(2):389-95 - PubMed
  30. Minerva Med. 2009 Jun;100(3):229-36 - PubMed
  31. N Engl J Med. 1996 Feb 1;334(5):292-5 - PubMed

Publication Types