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Omran A, Ahearn G, Bowers D, et al. Metabolic effects of sucralose on environmental bacteria. J Toxicol. 2013;2013:372986doi: 10.1155/2013/372986.
Omran, A., Ahearn, G., Bowers, D., Swenson, J., & Coughlin, C. (2013). Metabolic effects of sucralose on environmental bacteria. Journal of toxicology, 2013372986. https://doi.org/10.1155/2013/372986
Omran, Arthur, et al. "Metabolic effects of sucralose on environmental bacteria." Journal of toxicology vol. 2013 (2013): 372986. doi: https://doi.org/10.1155/2013/372986
Omran A, Ahearn G, Bowers D, Swenson J, Coughlin C. Metabolic effects of sucralose on environmental bacteria. J Toxicol. 2013;2013:372986. doi: 10.1155/2013/372986. Epub 2013 Dec 03. PMID: 24368913; PMCID: PMC3866777.
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J Toxicol. 2013;2013:372986. doi: 10.1155/2013/372986. Epub 2013 Dec 03.

Metabolic effects of sucralose on environmental bacteria.

Journal of toxicology

Arthur Omran, Gregory Ahearn, Doria Bowers, Janice Swenson, Charles Coughlin

Affiliations

  1. Department of Biology, University of North Florida, Jacksonville, FL 32224, USA.

PMID: 24368913 PMCID: PMC3866777 DOI: 10.1155/2013/372986

Abstract

Sucralose was developed as a low cost artificial sweetener that is nonmetabolizable in humans. Sucralose can withstand changes in pH and temperature and is not degraded by the wastewater treatment process. Since the molecule can withstand heat, acidification, and microbial degradation, it is accumulating in the environment and has been found in wastewater, estuaries, rivers, and the Gulf Stream. Environmental isolates were cultured in the presence of sucralose looking for potential sucralose metabolism or growth acceleration responses. Sucralose was found to be nonnutritive and demonstrated bacteriostatic effects on all six isolates. This growth inhibition was directly proportional to the concentration of sucralose exposure, and the amount of the growth inhibition appeared to be species-specific. The bacteriostatic effect may be due to a decrease in sucrose uptake by bacteria exposed to sucralose. We have determined that sucralose inhibits invertase and sucrose permease. These enzymes cannot catalyze hydrolysis or be effective in transmembrane transport of the sugar substitute. Current environmental concentrations should not have much of an effect on environmental bacteria since the bacteriostatic effect seems to be consecration based; however, as sucralose accumulates in the environment, we must consider it a contaminant, especially for microenvironments.

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