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Choong YT, Menuet C, Jancovski N, et al. Baroreceptor reflex control of heart rate in angiotensin type 1A receptor knockout mice. Physiol Rep. 2013;1(6):e00171doi: 10.1002/phy2.171.
Choong, Y. T., Menuet, C., Jancovski, N., & Allen, A. M. (2013). Baroreceptor reflex control of heart rate in angiotensin type 1A receptor knockout mice. Physiological reports, 1(6), e00171. https://doi.org/10.1002/phy2.171
Choong, Yan-Ting, et al. "Baroreceptor reflex control of heart rate in angiotensin type 1A receptor knockout mice." Physiological reports vol. 1,6 (2013): e00171. doi: https://doi.org/10.1002/phy2.171
Choong YT, Menuet C, Jancovski N, Allen AM. Baroreceptor reflex control of heart rate in angiotensin type 1A receptor knockout mice. Physiol Rep. 2013 Nov;1(6):e00171. doi: 10.1002/phy2.171. Epub 2013 Nov 26. PMID: 24400170; PMCID: PMC3871483.
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Physiol Rep. 2013 Nov;1(6):e00171. doi: 10.1002/phy2.171. Epub 2013 Nov 26.

Baroreceptor reflex control of heart rate in angiotensin type 1A receptor knockout mice.

Physiological reports

Yan-Ting Choong, Clement Menuet, Nikola Jancovski, Andrew M Allen

Affiliations

  1. Department of Physiology and Florey Institute of Neuroscience and Mental Health, The University of Melbourne Victoria, 3010, Australia.

PMID: 24400170 PMCID: PMC3871483 DOI: 10.1002/phy2.171

Abstract

The baroreceptor reflex dampens the short-term fluctuations in blood pressure by feedback modulation of heart rate (HR) and vascular resistance. Impairment of this reflex has been observed in hypertension and heart failure. Angiotensin II, a blood borne hormone, acts via its type 1A receptor to attenuate the baroreceptor reflex and this reflex is reported to be dramatically altered in angiotensin type 1A receptor knockout mice. This study sought to further investigate changes in the arterial and cardiopulmonary baroreceptor reflex control of HR in angiotensin II type 1A receptor knocked out mice. In artificially ventilated, isoflurane anesthetized mice, the arterial and cardiopulmonary baroreceptor reflexes were activated via injection or slow infusions, respectively, of phenylephrine and sodium nitroprusside through the jugular vein. We observed no impairment of either the arterial or cardiopulmonary baroreceptor reflex control of HR in angiotensin type 1A receptor knockout mice.

Keywords: Angiotensin II; arterial baroreceptor reflex; blood pressure; cardiopulmonary baroreceptor reflex; isoflurane

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