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Petsky HL, Kynaston JA, McElrea M, et al. Cough and exhaled nitric oxide levels: what happens with exercise?. Front Pediatr. 2013;1:30doi: 10.3389/fped.2013.00030.
Petsky, H. L., Kynaston, J. A., McElrea, M., Turner, C., Isles, A., & Chang, A. B. (2013). Cough and exhaled nitric oxide levels: what happens with exercise?. Frontiers in pediatrics, 130. https://doi.org/10.3389/fped.2013.00030
Petsky, Helen L, et al. "Cough and exhaled nitric oxide levels: what happens with exercise?." Frontiers in pediatrics vol. 1 (2013): 30. doi: https://doi.org/10.3389/fped.2013.00030
Petsky HL, Kynaston JA, McElrea M, Turner C, Isles A, Chang AB. Cough and exhaled nitric oxide levels: what happens with exercise?. Front Pediatr. 2013 Oct 24;1:30. doi: 10.3389/fped.2013.00030. eCollection 2013. PMID: 24400276; PMCID: PMC3864220.
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Front Pediatr. 2013 Oct 24;1:30. doi: 10.3389/fped.2013.00030. eCollection 2013.

Cough and exhaled nitric oxide levels: what happens with exercise?.

Frontiers in pediatrics

Helen L Petsky, Jennifer Anne Kynaston, Margaret McElrea, Catherine Turner, Alan Isles, Anne B Chang

Affiliations

  1. Queensland Children's Medical Research Institute, Queensland University of Technology , Brisbane, QLD , Australia ; Queensland Children's Respiratory Centre, Royal Children's Hospital , Brisbane, QLD , Australia ; School of Nursing and Midwifery, The University of Queensland , Brisbane, QLD , Australia.
  2. General Paediatrics, Royal Children's Hospital , Brisbane, QLD , Australia.
  3. Queensland Children's Respiratory Centre, Royal Children's Hospital , Brisbane, QLD , Australia.
  4. School of Nursing and Midwifery, The University of Queensland , Brisbane, QLD , Australia.
  5. Queensland Children's Medical Research Institute, Queensland University of Technology , Brisbane, QLD , Australia ; Queensland Children's Respiratory Centre, Royal Children's Hospital , Brisbane, QLD , Australia.
  6. Queensland Children's Medical Research Institute, Queensland University of Technology , Brisbane, QLD , Australia ; Queensland Children's Respiratory Centre, Royal Children's Hospital , Brisbane, QLD , Australia ; Child Health Division, Menzies School of Health , Darwin, NT , Australia.

PMID: 24400276 PMCID: PMC3864220 DOI: 10.3389/fped.2013.00030

Abstract

Cough associated with exertion is often used as a surrogate marker of asthma. However, to date there are no studies that have objectively measured cough in association with exercise in children. Our primary aim was to examine whether children with a pre-existing cough have an increase in cough frequency during and post-exercise. We hypothesized that children with any coughing illness will have an increase in cough frequency post-exercise regardless of the presence of exercise-induced broncho-constriction (EIB) or atopy. In addition, we hypothesized that Fractional exhaled nitric oxide (FeNO) levels decreases post-exercise regardless of the presence of EIB or atopy. Children with chronic cough and a control group without cough undertook an exercise challenge, FeNO measurements and a skin prick test, and wore a 24-h voice recorder to objectively measure cough frequency. The association between recorded cough frequency, exercise, atopy, and presence of EIB was tested. We also determined if the change in FeNO post exercise related to atopy or EIB. Of the 50 children recruited (35 with cough, 15 control), 7 had EIB. Children with cough had a significant increase in cough counts (median 7.0, inter-quartile ranges, 0.5, 24.5) compared to controls (2.0, IQR 0, 5.0, p = 0.028) post-exercise. Presence of atopy or EIB did not influence cough frequency. FeNO level was significantly lower post-exercise in both groups but the change was not influenced by atopy or EIB. Cough post-exertion is likely a generic response in children with a current cough. FeNO level decreases post-exercise irrespective of the presence of atopy or EIB. A larger study is necessary confirm or refute our findings.

Keywords: FeNO; atopy; cough; exercise-induced broncho-constriction; pediatrics

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