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Corno AF, Cai X, Jones CB, et al. Congestive heart failure: experimental model. Front Pediatr. 2013;1:33doi: 10.3389/fped.2013.00033.
Corno, A. F., Cai, X., Jones, C. B., Mondani, G., Boyett, M. R., Jarvis, J. C., & Hart, G. (2013). Congestive heart failure: experimental model. Frontiers in pediatrics, 133. https://doi.org/10.3389/fped.2013.00033
Corno, Antonio Francesco, et al. "Congestive heart failure: experimental model." Frontiers in pediatrics vol. 1 (2013): 33. doi: https://doi.org/10.3389/fped.2013.00033
Corno AF, Cai X, Jones CB, Mondani G, Boyett MR, Jarvis JC, Hart G. Congestive heart failure: experimental model. Front Pediatr. 2013 Oct 28;1:33. doi: 10.3389/fped.2013.00033. eCollection 2013. PMID: 24400279; PMCID: PMC3864258.
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Front Pediatr. 2013 Oct 28;1:33. doi: 10.3389/fped.2013.00033. eCollection 2013.

Congestive heart failure: experimental model.

Frontiers in pediatrics

Antonio Francesco Corno, Xue Cai, Caroline B Jones, Giuseppina Mondani, Mark R Boyett, Jonathan Charles Jarvis, George Hart

Affiliations

  1. School of Medical Sciences, Health Campus, University Sains Malaysia , Kubang Kerian, Kelantan , Malaysia.
  2. Core Technology Facility, University of Manchester , Manchester , UK.
  3. Core Technology Facility, University of Manchester , Manchester , UK ; Alder Hey Children NHS Foundation Trust , Liverpool , UK.
  4. John Moores University , Liverpool , UK.

PMID: 24400279 PMCID: PMC3864258 DOI: 10.3389/fped.2013.00033

Abstract

INTRODUCTION: Surgically induced, combined volume and pressure overload has been used in rabbits to create a simplified and reproducible model of acute left ventricular (LV) failure.

MATERIALS AND METHODS: New Zealand white male rabbits (n = 24, mean weight 3.1 ± 0.2 kg) were randomly assigned to either the Control group (n = 10) or to the Heart Failure group (HF, n = 14). Animals in the Control group underwent "sham" procedures. Animals in the HF group underwent procedures to induce LV volume overload by inducing severe aortic valve regurgitation with aortic cusp disruption and pressure overload using an occlusive silver clip positioned around the pre-renal abdominal aorta.

RESULTS: Following Procedure-1 (volume overload) echocardiography confirmed severe aortic regurgitation in all animals in the HF group, with increased mean pulse pressure difference from 18 ± 3 to 38 ± 3 mmHg (P < 0.0001). After Procedure-2 (pressure overload) all animals in the HF group showed clinical and echocardiographic signs of constriction of the abdominal aorta and echocardiography confirmed progressively declining LV function. At the end of the protocol there was a significant increase of the heart/body weight ratio in the HF group vs. Control group (4.6 ± 0.2 vs. 2.9 ± 0.1 g/kg, P < 0.05), and echocardiography showed in HF group significant increase of the LV end-diastolic diameter (2.15 ± 0.09 vs. 1.49 ± 0.03 cm, P < 0.001) and reduction of the LV shortening fraction (26.3 ± 3.8 vs. 41.3 ± 1.6%, P < 0.001).

CONCLUSION: This experimental model: (a) consistently produces LV hypertrophy/dilatation and subsequent congestive heart failure, (b) provides new data on the time course of LV dilatation, hypertrophy and failure, (c) allows study of the progress and evolution of LV systolic and diastolic dysfunction in the presence of induced LV failure, (d) is suitable to study intervention or pharmacological administration to reduce the negative effects of acute LV failure.

Keywords: congestive heart failure; experimental research; left heart failure; ventricular dilatation; ventricular hyprtrophy

References

  1. J Nucl Cardiol. 1997 Jan-Feb;4(1 Pt 1):25-32 - PubMed
  2. Am Surg. 1977 Dec;43(12):771-7 - PubMed
  3. Cardiovasc Res. 2005 Jan 1;65(1):83-92 - PubMed
  4. Blood Press. 2010 Apr;19(2):119-25 - PubMed
  5. Circulation. 2004 Sep 14;110(11):1477-83 - PubMed
  6. J Vasc Surg. 2013 Mar;57(3):806-815.e1 - PubMed
  7. Am J Ther. 1998 May;5(3):139-46 - PubMed
  8. Am J Physiol Heart Circ Physiol. 2009 Dec;297(6):H2044-53 - PubMed
  9. Clin Exp Pharmacol Physiol. 2002 Jan-Feb;29(1-2):26-31 - PubMed
  10. Braz J Med Biol Res. 2000 Apr;33(4):431-8 - PubMed
  11. Am J Physiol. 1992 Jul;263(1 Pt 2):H226-33 - PubMed
  12. Am J Physiol Heart Circ Physiol. 2013 Jan 15;304(2):H282-93 - PubMed
  13. J Card Fail. 2013 Jul;19(7):478-93 - PubMed
  14. Hypertension. 1997 Apr;29(4):1025-30 - PubMed
  15. Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1888-95 - PubMed
  16. Proc Soc Exp Biol Med. 1995 May;209(1):32-7 - PubMed
  17. J Hypertens. 1998 May;16(5):657-64 - PubMed
  18. Am J Physiol. 1994 Aug;267(2 Pt 2):H556-62 - PubMed
  19. Curr Heart Fail Rep. 2013 Sep;10(3):190-7 - PubMed
  20. Am J Physiol Regul Integr Comp Physiol. 2011 Jun;300(6):R1468-75 - PubMed
  21. J Heart Valve Dis. 2012 Jul;21(4):478-86 - PubMed
  22. Pharmacol Rep. 2010 Sep-Oct;62(5):874-82 - PubMed
  23. J Appl Physiol (1985). 2012 Feb;112(3):362-6 - PubMed
  24. Am J Physiol. 1991 Aug;261(2 Pt 2):H301-7 - PubMed
  25. Circ Res. 1975 Aug;37(2):183-90 - PubMed
  26. Curr Cardiol Rep. 2013 Sep;15(9):393 - PubMed
  27. Circulation. 2000 Jun 27;101(25):2975-80 - PubMed
  28. J Heart Valve Dis. 2002 Jan;11(1):128-34 - PubMed
  29. Pharmacol Res. 2003 Jul;48(1):17-24 - PubMed
  30. Adv Exp Med Biol. 1997;432:71-82 - PubMed
  31. Life Sci. 2006 Jul 4;79(6):596-600 - PubMed
  32. J Pharm Pharmacol. 2002 Jan;54(1):139-46 - PubMed
  33. J Pharmacol Sci. 2010;114(3):311-9 - PubMed
  34. Clin Pharmacol Ther. 2013 Oct;94(4):430-2 - PubMed
  35. PLoS One. 2012;7(4):e35299 - PubMed
  36. J Invest Surg. 2003 Jan-Feb;16(1):35-44 - PubMed
  37. Int J Exp Pathol. 1994 Jun;75(3):179-90 - PubMed
  38. Am J Physiol Renal Physiol. 2011 Sep;301(3):F615-21 - PubMed
  39. Cardiovasc Res. 1994 Oct;28(10):1547-54 - PubMed
  40. Cardiology. 1998 Oct;90(2):101-9 - PubMed
  41. Am Heart J. 2013 Aug;166(2):349-56 - PubMed
  42. Can J Physiol Pharmacol. 2012 Jan;90(1):1-12 - PubMed

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