Display options
Share it on

ACS Med Chem Lett. 2013 Oct 04;4(12):1148-1151. doi: 10.1021/ml400208v.

Discovery of potent and selective inhibitors of .

ACS medicinal chemistry letters

Nilesh Zaware, Hitesh Sharma, Jie Yang, Ravi Kumar Vyas Devambatla, Sherry F Queener, Karen S Anderson, Aleem Gangjee

Affiliations

  1. Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, 600 Forbes Avenue, Pittsburgh, PA 15282, United States.
  2. Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06511, United States.
  3. Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN 46202, United States.

PMID: 24470841 PMCID: PMC3901304 DOI: 10.1021/ml400208v

Abstract

Infection by the parasite

Keywords: Active-site inhibitors; Crystal structure; Opportunistic infection; Thymidylate-synthase inhibitors; Toxoplasma gondii

References

  1. Clin Pharmacol Ther. 2013 May;93(5):382-4 - PubMed
  2. Nature. 2002 Feb 21;415(6874):926-9 - PubMed
  3. J Med Chem. 2010 Feb 25;53(4):1563-78 - PubMed
  4. MMWR Recomm Rep. 2009 Apr 10;58(RR-4):1-207; quiz CE1-4 - PubMed
  5. J Med Chem. 1996 Mar 15;39(6):1271-80 - PubMed
  6. Curr Drug Targets. 2007 Jan;8(1):31-47 - PubMed
  7. Biochemistry. 2013 Oct 15;52(41):7305-7317 - PubMed
  8. Mol Biochem Parasitol. 2005 Sep;143(1):121-4 - PubMed
  9. J Infect Dis. 2002 Jun 1;185(11):1637-43 - PubMed
  10. Am J Trop Med Hyg. 1984 May;33(3):325-30 - PubMed
  11. ChemMedChem. 2008 Mar;3(3):392-401 - PubMed
  12. J Org Chem. 2008 Jul 18;73(14):5625-8 - PubMed
  13. J Med Chem. 1993 Mar 19;36(6):733-46 - PubMed
  14. Lancet. 2004 Jun 12;363(9425):1965-76 - PubMed

Publication Types

Grant support