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Chem Heterocycl Compd (N Y). 2012 Mar 01;47(12):1516-1526. doi: 10.1007/s10593-012-0942-1.

ORGANOCOPPER-MEDIATED TWO-COMPONENT .

Chemistry of heterocyclic compounds

D Chernyak, V Gevorgyan

Affiliations

  1. University of Illinois at Chicago, 845 West Taylor St., Chicago 60607, Illinois, USA.

PMID: 24501430 PMCID: PMC3910007 DOI: 10.1007/s10593-012-0942-1

Abstract

Organocuprates efficiently undergo reaction with heterocyclic propargyl mesylates at low temperature to produce N-fused heterocycles. The copper reagent plays a "double duty" in this cascade transformation, which proceeds through an S

Keywords: allenes; cycloisomerization; indolizines; propargyl mesylates; synthetic methods

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